Article Per Year (5 Year)
p-Index From 2020 - 2025
0.983
P-Index
This Author published in this journals
All Journal Medical Journal of Indonesia Majalah Patologi Indonesia Jurnal Respirasi (JR) JURNAL ETIKA KEDOKTERAN INDONESIA Indonesian Journal of Medical Chemistry and Bioinformatics
Irandi Putra Pratomo
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine/Pulmonology And Respiratory Medicine Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, Indonesia/Bioinformatics Core Facilities, Indonesian Medical Educa
Chemistry Computer Science & IT Health Professions Medicine & Pharmacology Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search

 1 
Association between dietary intake of vitamin A, C, and E as antioxidants and cognitive function in the elderly at a nursing home Tani, Jowy; Widjaja, Ivan R.; Tedja, Irwin; Pratomo, Irandi P.; Siagian, Ira; Fahri, Indra; Amri, Zarni; Bardosono, Saptawati
Medical Journal of Indonesia Vol 16, No 4 (2007): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.577 KB) | DOI: 10.13181/mji.v16i4.289

Abstract

As oxidative stress is considered one of the major mechanisms underlying degenerative changes, antioxidants from dietary sources, such as vitamin A, C, and E, may have protective effects against oxidative stress and thus be able to prevent or delay cognitive impairment in the elderly. This cross sectional study was designed to determine the association between dietary intake of vitamin A, C, and E and the presence of cognitive impairment in the elderly, along with other factors. Subjects included 36 residents from a nursing home in Jakarta, Indonesia. The data obtained including daily nutrition intake values one week prior to sampling converted from semi- quantitative food frequency questionnaire (SFFQ) results, Mini Mental State Examination (MMSE) scores, and anthropometrical measurement results. This study showed that while sex, age, education, nutritional status, and macronutrients intake were not significantly associated with presence of cognitive impairment, significant positive correlation existed between education and MMSE score (p=0.036, r=0.351). Higher vitamin A and vitamin C intake were shown to be significantly associated with lower incidence of cognitive impairment (p=0.022 and p=0.045, respectively). Moreover, vitamin C was shown to have significant positive correlation with MMSE score (p=0.031, r=0.359). However, the association between vitamin E and the presence of impairment was not significant (p=0.129). Higher intake of vitamin A and C may delay or prevent cognitive impairment in the elderly. Higher intake of vitamin C may contribute to better cognitive functioning. The findings may be explained by the two antioxidant vitamins’ protective effects against neurode generative processes cause by oxidative stress. (Med J Indones 2007; 16:261-6)Keywords: antioxidant, vitamin A, vitamin C, vitamin E, cognitive impairment, the elderly
Peran Sel T Memori dalam Pengendalian Pandemi Covid-19 Kusmardi; Dimas Ramadhian N; Irandi P Pratomo; Aryo Tedjo
Majalah Patologi Indonesia Vol 30 No 2 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.48 KB) | DOI: 10.55816/mpi.v30i2.476

Abstract

ABSTRACTEvaluation of changes in antibody orders is a common exclusion in vaccination strategies because of the method ofanalysis. The fact that protection by antibodies produced by the Severe Acute Respiratory Syndrome Coronavirus-2(Sars-Cov-2) infection both naturally and through vaccines will decrease in less than one year, is a challenge for acountry with a large population like Indonesia to run its vaccination program. The main challenge is whether thevaccination strategy adopted will overcome the vaccine barrier and the race between the rate of vaccination and therate of viral mutation and antibody reduction. In addition to antibodies, the adaptive immune system is also run by Tcells that are included in the cell-mediated immune system (CMI) group. In patients with asymptomatic or mildsymptoms of Coronavirus 2019 (Covid-19), T and CMI responses are known to appear in some patients who are notknown to have been exposed to Sars-Cov-2 before. This evidence suggests that the adaptive catastrophe for SarsCov-2 has been acquired by ordering memory T cells and may last longer than previously thought. For countries withlarge populations, this will certainly help overcome the limitations of vaccines and the time needed to implement theirvaccination strategies.
Konsekuensi Disinformasi Medis di Era Literasi Kesehatan Digital terhadap Integritas Bangsa Indonesia Irandi Putra Pratomo; Gatut Priyonugroho; Aris Ramdhani; Ratna Suryani Gandana
Jurnal Etika Kedokteran Indonesia Vol 5, No 1 (2021): VOL 5, NO 1 (2021)
Publisher : Majelis Kehormatan Etik Indonesia PBIDI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26880/jeki.v5i1.53

Abstract

Perkembangan pesat teknologi informasi digital telah menjamah seluruh negara di dunia, tidak terkecuali Indonesia. Informasi dengan jumlah yang sangat besar, disebut juga sebagai mahadata, yang kini tersimpan di berbagai sudut dunia maya telah dapat diperoleh dalam sekejap dengan hanya menuliskan kata kunci menggunakan gawai. Mahadata informasi ini merupakan pisau bermata dua yang dapat mempengaruhi pola pikir dan tingkah laku masyarakat di suatu negara, khususnya informasi kedokteran dan kesehatan. Masa wabah COVID-19, suatu penyakit baru yang masih belum memiliki fakta keilmuan yang definitif pada saat tulisan ini dibuat, merupakan contoh situasi nyata yang telah mengakibatkan disrupsi atau ketidakteraturan informasi masif yang simpang siur melewati layar gawai. Kondisi ini mengakibatkan kekuatiran dan ketidakpastian masyarakat untuk menghadapi wabah. Tulisan ini membahas konsekuensi disinformasi medis terhadap integritas bangsa Indonesia, sehingga diharapkan dapat menjadi sumber introspeksi profesional kesehatan dalam menghadapi disrupsi informasi di era literasi kesehatan digital ini.
Preparation and Findings in Diagnostic and Therapeutic Flexible Fiberoptic Bronchoscopy Procedures in Patients with COVID-19 Irandi Putra Pratomo; Hario Baskoro; Dicky Soehardiman; Prasenohadi Prasenohadi; Tutug Kinasih; Ahmad Fauzi; Ike Maretta; Nachita Putri; Kentaro Tokumo
Jurnal Respirasi Vol. 9 No. 1 (2023): January 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.1.2023.72-79

Abstract

The coronavirus disease 2019 (COVID-19), which has raised concerns about infection control for every clinical procedure, including flexible fiberoptic bronchoscopy (FFB), has drawn the attention of clinicians across the globe. A pulmonologist frequently conducts this procedure to diagnose and treat pulmonary diseases like COVID-19. This procedure involves direct airway observation and generates aerosol from the patient. However, it is considered a double-edged sword, as the risk of infection and instrument contamination always haunts its clinical benefit to the patients and the operators. Therefore, a guideline for preparing and indicating FFB in COVID-19 must be addressed appropriately by emphasizing the importance of infection prevention and control. Fortunately, several recommendations and findings have emerged over the past three years, which should support safe FFB procedures for its operators with controlled infection. This study summarizes the indication, objective, contraindication, risk, preparation, and findings in diagnostic and therapeutic FFB patients with COVID-19.
The Role of Genome-Wide Association Study in Pulmonary Disease Diagnostics: A Review in Medical Bioinformatics Rossalyn Andromeda; Irandi Putra Pratomo; Ahmad Fauzi; Tutug Kinasih; Prasenohadi Prasenohadi; Arif Santoso; Kentaro Tokumo
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.76-84

Abstract

Biomedical science, which initially required only conventional research in the laboratory, currently involves information technology and has created bioinformatics in its development. Bioinformatics, a branch of biology, quantitatively analyzes information within biological macromolecules using software. Contemporary applications of bioinformatics have advanced biotechnological, medical, and pharmaceutical practices. Among the established applications of bioinformatics is diagnosing lung diseases using the genome-wide association study (GWAS) technique. Owing to sequencing technology and rapid computational methods, this technique is applied to analyze the link between genes with essential traits in the population, thus mapping the target genes to diagnose and treat diseases. The lung diseases diagnosed using GWAS include the responsible locus in asthma, chronic obstructive pulmonary disease (COPD), and lung cancer. Moreover, it can identify the treatment for COPD and suggest a new locus in lung cancer. Advancing the current gene-mapping technology demands genotype and phenotype data to study disease-linked genomes. Currently, bioinformatics is barely known and receives little attention in Indonesia. However, it can grow rapidly through open-source basis data and cross-disciplinary collaboration.
Molecular Insights into Propylthiouracil as a Thyroid Peroxidase Inhibitor: A Computational Study Approach Suryandari, Dwi Anita; Yunaini, Luluk; Sunaryo, Hadi; Istiadi, Khaerunissa Anbar; Pratomo, Irandi Putra
Indonesian Journal of Medical Chemistry and Bioinformatics
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Thyroid peroxidase (TPO) is a crucial enzyme in the biosynthesis of thyroid hormones, catalyzing the iodination of tyrosine residues in thyroglobulin and the coupling of iodotyrosines to form thyroxine (T4) and triiodothyronine (T3). Propylthiouracil (PTU) is an antithyroid drug commonly used to manage hyperthyroidism by inhibiting TPO. Understanding the molecular interactions between TPO and PTU can provide insights into the inhibitory mechanisms and guide the design of more effective antithyroid medications. Objective: This study aims to elucidate the binding interactions between TPO and PTU through molecular docking, providing a detailed understanding of how PTU inhibits TPO activity. Methods: The three-dimensional structure of TPO was obtained from Prosite and modelling by swissmodel and prepared for docking. The structure of PTU was optimized, and molecular docking was performed using AutoDock. The binding affinity, binding poses, and key interactions between TPO and PTU were analyzed. Visualization of the docking results was performed using PyMOL to identify critical residues involved in PTU binding. Results: The docking analysis revealed that PTU binds effectively to the active site of TPO with a binding affinity of -5.45 kcal/mol. The interaction involves coordination with the heme group and several key residues, including His239, which coordinates the heme, and Ser314, which forms hydrogen bonds with PTU. Additionally, hydrophobic interactions with residues Phe241 and Ile399 stabilize the binding of PTU in the active site. Conclusion: The docking study highlights the significant interactions between PTU and TPO, elucidating the molecular basis of TPO inhibition by PTU. The binding affinity and key interactions identified in this study provide a foundation for the design of more potent antithyroid drugs.
Co-Authors Ahmad Fauzi Ahmad Fauzi Arif Santoso Aris Ramdhani Aryo Tedjo Dimas Ramadhian N Dwi Anita Suryandari Gatut Priyonugroho Hadi Sunaryo Hario Baskoro Ike Maretta Indra Fahri Ira Siagian Irwin Tedja Ivan R. Widjaja Jowy Tani Kentaro Tokumo Khaerunissa Anbar Istiadi Kusmardi Kusmardi Luluk Yunaini Nachita Putri Prasenohadi Prasenohadi Prasenohadi Prasenohadi Ratna Suryani Gandana Rossalyn Andromeda Saptawati Bardosono Soehardiman, Dicky Tutug Kinasih Tutug Kinasih Zarni Amri