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All Journal Jurnal Respirasi (JR)
Indra Yovi
Arifin Achmad General Hospital, Pekanbaru, Indonesia.
Health Professions Medicine & Pharmacology Public Health

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Ki-67 Expression and Histopathological Type, Metastatic Status, and Risk Factors in Lung Cancer Muhammad Khairani; Sri Melati Munir; Darmawi Darmawi; Indra Yovi; Indi Esha; Zarfiardy Aksa Fauzi; Zahtamal Zahtamal
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.35-43

Abstract

Introduction: Lung cancer remains a leading cause of cancer-related morbidity and mortality worldwide. In Indonesia, the incidence and death rates associated with this disease remain alarmingly high. Ki-67 is a potential biomarker for assessing cellular proliferation and metastatic potential. However, its clinical application in lung cancer remains inconsistent. This study aimed to analyze the association between Ki-67 expression and histopathological subtype, metastatic status, and clinical risk factors in patients with lung cancer. Methods: This study enrolled 42 patients diagnosed with lung cancer at Arifin Achmad General Hospital, Pekanbaru, Indonesia. Statistical analysis used the Chi-square or Fisher’s exact test (non-parametric tests) for categorical data and the Kolmogorov-Smirnov test, depending on the data characteristics. Participants were selected based on predefined inclusion criteria, complete medical documentation, and available Ki-67 immunohistochemistry results. Results: Among the 42 patients analyzed, 34 (80.9%) exhibited metastasis. The findings revealed a significant correlation between Ki-67 expression and metastasis (p=0.0038), whereas no significant associations were observed with age, sex, smoking status, or histopathological classification. Most patients (approximately 69%) had low Ki-67 expression. Conclusion: Ki-67 expression was associated with metastatic status in patients with lung cancer and might serve as a prognostic biomarker. Further studies with larger sample sizes are needed to validate these findings.
Non-Tuberculous Mycobacteria: Emerging Pathogens in Pulmonary and Extrapulmonary Infections - A Comprehensive Review Irene Oinike; Rohani Lasmaria; Zarfiardy Aksa Fauzi; Indra Yovi; Nadya Arawinda Andar
Jurnal Respirasi Vol. 12 No. 3 (2026): September 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.3.2026.300-308

Abstract

Non-Tuberculous Mycobacteria (NTM) refers to a group of Mycobacterium other than Mycobacterium tuberculosis complex and Mycobacterium leprae, which are commonly found in air, soil and water. Although most NTM species are non-pathogenic, certain species can cause pulmonary and extrapulmonary infection, particularly in immunocompromised. Diagnosing pulmonary infections caused by non-tuberculous mycobacteria requires an integrated assessment of clinical manifestations, physical examination, radiology and microbiology or histopathology examination. In extrapulmonary infection, diagnosis involves a combination of clinical symptoms, physical examination, microbiology and histopathology examination. Molecular examination may also be employed as an adjunct to confirm the presence of NTM infection. NTM infection may become progressive, therefore require appropriate treatment to reduce morbidity and mortality. Treatment consists of both pharmacological approaches using combination antibiotic regimens and non-pharmacological such as supportive therapy, surgery and physiotherapy. This literature review aims to provide a comprehensive overview of definition, classification, pathogenesis, diagnosis, management and prognosis of NTM infection.
Co-Authors Darmawi Darmawi Indi Esha Irene Oinike Muhammad Khairani Nadya Arawinda Andar Rohani Lasmaria Sri Melati Munir Zahtamal Zahtamal Zarfiardy Aksa Fauzi Zarfiardy Aksa Fauzi