Background: Ineffective breastfeeding remains a common postpartum nursing problem and may be manifested by insufficient milk production, poor infant latch, low breastfeeding frequency, infant dissatisfaction after feeding, and maternal anxiety. Mothers with ineffective breastfeeding require an intervention that addresses not only physiological milk production but also maternal knowledge, confidence, emotional readiness, and spiritual meaning. Spiritual breastfeeding education combined with the Stimulation of Endorphin, Oxytocin, and Suggestive massage method and digital learning media may offer a holistic approach to support breastfeeding success. Objective: This study aimed to describe the application of spiritual breastfeeding education and the SPEOS method using the BEST for Moms e-book among mothers with ineffective breastfeeding. Methods: This study used a descriptive case study design with a nursing care approach. The study was conducted in Tanjung Baru Village, Baturaja Timur, and involved two Muslim breastfeeding mothers with infants aged 0–1 month who experienced ineffective breastfeeding and were able to access the e-book. The intervention was delivered in eight visits over four weeks and included spiritual breastfeeding education, endorphin massage stimulation, oxytocin massage, suggestive techniques, and guided use of the BEST for Moms e-book. Data were collected using an ineffective breastfeeding assessment format, a spiritual breastfeeding education questionnaire, an intervention checklist, the Breastfeeding Self-Efficacy Scale–Short Form, and standard operating procedures for the intervention. Data were analyzed descriptively by comparing breastfeeding indicators before and after the intervention. Results: Both mothers showed improvement after the intervention. Breastfeeding self-efficacy increased from 51 to 59 in the first case and from 55 to 67 in the second case. Breastfeeding frequency and infant urination frequency increased from fewer than eight times per day to more than eight times within 24 hours in both cases. Maternal anxiety decreased, maternal confidence improved, infant latch and breastfeeding position became more appropriate, and infants appeared calmer after breastfeeding. Ineffective breastfeeding was resolved on day seven in the first case and on day six in the second case. Conclusion: Spiritual breastfeeding education and the SPEOS method using the BEST for Moms e-book may improve breastfeeding effectiveness, maternal self-efficacy, and infant feeding adequacy among mothers with ineffective breastfeeding.