Article Per Year (5 Year)
p-Index From 2021 - 2026
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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research
Fita Rahmawati
Department of Clinical Pharmacy and Pharmacotherapy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
Environmental Science Public Health

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Safety Assessment of Proton-Pump Inhibitors: Study of Cardiovascular Adverse Events Using Global Pharmacovigilance Data Salma Nur Azizah Azzahra; Fita Rahmawati; Agung Endro Nugroho
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.107840

Abstract

Proton-pump inhibitors (PPIs) have been associated with adverse cardiovascular events, underscoring the need for comprehensive safety evaluation, yet systematic consolidation of data on PPI-related adverse drug reactions (ADRs) leading to cardiovascular events remains lacking. This study aims to descriptively analyze cardiovascular events related to PPI use to summarize their safety profile. A quantitative descriptive analysis was performed on cardiovascular ADRs associated with PPIs using global pharmacovigilance data. The top 25 reported cardiovascular ADRs for each PPI were identified from VigiAccess launched by World Health Organization (WHO) global database. We selected the same 20 set potential ADRs using Venny 2.1.0 to enhance the comparability of data and we summarized by frequency and percentage. A total of 15,263 cardiovascular ADR cases were identified. Omeprazole showed the highest reports, mainly palpitations (1,675 cases; 28.5%), cardiac flutter (759 cases; 12.91%), tachycardia (549 cases; 9.34%), and myocardial infarction (498 cases; 8.47%). Pantoprazole reported palpitations (893 cases; 27.43%), tachycardia (332 cases; 10.20%), and cardiac flutter (326 cases; 10.01%), while lansoprazole (1,782 cases; 11.7%) reported palpitations (451 cases; 25.3%), tachycardia (166 cases; 9.3%), and cardiac flutter (153 cases; 8.6%). Esomeprazole was most associated with myocardial infarction (951 cases; 21.88%), palpitations (621 cases; 14.29%), and cardiac failure congestive (380 cases; 8.74%). PPIs are associated with cardiovascular ADRs such as palpitations and myocardial infarction, emphasizing the importance of careful risk assessment during therapy.
Drug-Related Problems Leading to Hospitalization: A Literature Review Annisa Nur Kharisma; Fita Rahmawati; Soni Siswanto
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 11, No 1 (2026)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v11i1.107839

Abstract

Background: Drug-related problems (DRPs) are described as problems associated with medications that can lead to treatment failure and may also cause hospital admissions. The novelty of this study is that it supplements previous research data with the latest data on DRPs leading to hospital stays, specifically articles published between 2021 and 2025. Objective: This study aims to identify the prevalence of hospitalization due to DRPs, the types of DRPs that lead to hospital admissions, the medications involved, and the risk factors for DRPs. Methods: A literature search was conducted across the PubMed, ScienceDirect, and Scopus databases, limiting publication years to 2021-2025. Results: In the 12 studies reviewed, the frequency of hospitalization due to DRP varied between 5,0% to 57,9%. Adverse drug reactions (ADRs), non-compliance, drug interactions, dosing errors, and incomplete therapy indication were the most common types of DRPs that lead to hospitalization. The drugs most commonly involved in DRPs were antidiabetic agents, cardiovascular agents, diuretics, and antineoplastic agents. Age, polypharmacy, and the number and severity of comorbidities were identified as primary risk factors for hospitalization caused by DRPs. Conclusion: The frequency of hospitalization due to DRP varied between 5,0% to 57,9%. Factors such as age, number of medications, and comorbidities influence the frequency of DRPs.
Co-Authors Agung Endro Nugroho Annisa Nur Kharisma Salma Nur Azizah Azzahra Soni Siswanto