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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Medical Laboratory Journal
Desi Rahmasari
Universitas Duta Bangsa Surakarta
Health Professions Public Health

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Hubungan antara Kerusakan DNA dan Mekanisme Perbaikan Seluler: Tinjauan Literatur Azizah Zahra Nur Fitria; Margaretha Alesandria Natasya Weka; Azlinatul Lulu Kharolaini; Desi Rahmasari; Pramai Sheila Eka Khoireina; Feni Atika Tsuroyya; Septi Puspita Kurniawati; Tyara Avrilyanti Ghea Indriansyah; Liss Dyah Dewi Arini
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 4 No. 2 (2026): April : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v4i2.972

Abstract

DNA damage is a fundamental biological phenomenon that occurs due to endogenous and exogenous factors such as radiation, chemical exposure, and replication errors. If not properly repaired, DNA damage can lead to genomic instability, mutations, and the development of various diseases, including cancer. This literature review aims to examine the relationship between DNA damage and cellular repair mechanisms in maintaining genomic integrity. The method used in this study is a literature review of national scientific journals that discuss types of DNA damage, molecular markers of DNA damage, and cellular repair pathways. The findings indicate that cells possess complex and coordinated DNA repair systems, including base excision repair, nucleotide excision repair, mismatch repair, and double-strand break repair mechanisms, which play crucial roles in preserving cellular stability. The effectiveness of these repair mechanisms is influenced by the type and extent of DNA damage. Understanding the interaction between DNA damage and repair pathways provides important implications for the development of disease prevention strategies, diagnostic biomarkers, and therapeutic approaches in molecular biology and medical sciences.
Pemanfaatan Mikroskop dalam Menanggapi Fenomena Resistensi Antibiotik pada Bakteri Patogen Desi Rahmasari; Devina Adira Azzahra; Hanayu Anindya Nareswari; Nasywarana Putri Panjaitan; Rizka Felithia; Elsa Oktavia Ramadhani; Liss Dyah Dewi Arini
Calory Journal Medical Laboratory Journal Vol. 3 No. 3 (2025): September : Medical Laboratory Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/caloryjournal.v3i2.778

Abstract

Antibiotic resistance has emerged as one of the most critical challenges in modern healthcare. Pathogenic bacteria that were once susceptible to antibiotics have developed survival mechanisms, making infections increasingly difficult to treat. Understanding and combating this issue requires advanced tools, with microscopy playing a pivotal role. Microscopes enable researchers to observe bacterial morphological changes, biofilm formation, and antibiotic-bacteria interactions at molecular levels. Various microscopy techniques – including light microscopy, electron microscopy, and fluorescence microscopy – have significantly contributed to both research and clinical diagnostics. Through a literature review approach, this article examines how microscopy facilitates antibiotic resistance studies and supports the development of more effective treatment strategies.
Co-Authors Azizah Zahra Nur Fitria Azlinatul Lulu Kharolaini Devina Adira Azzahra Elsa Oktavia Ramadhani Feni Atika Tsuroyya Hanayu Anindya Nareswari Margaretha Alesandria Natasya Weka Nasywarana Putri Panjaitan Pramai Sheila Eka Khoireina Rizka Felithia Septi Puspita Kurniawati Tyara Avrilyanti Ghea Indriansyah