Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga.
Rosalia Dwi Permatasari
Universitas Muhammadiyah Malang
Health Professions Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Effect of Red Apple Peel Extract on Serum Histamine Levels in a Rat Model of Allergic Rhinitis Indra Setiawan; Tara Mandirica; Arindo Kusuma; Rosalia Dwi Permatasari; Miftha Churochman
Saintika Medika : Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol. 22 No. 1 (2026): June 2026
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol22.SMUMM1.44828

Abstract

Allergic rhinitis (AR) remains a prevalent inflammatory disorder for which long-term pharmacological management is often constrained by adverse effects. This study investigated the impact of red apple peel extract (Malus domestica 'Rome Beauty'), a quercetin-rich by-product sourced from Malang–Batu, on serum histamine concentrations in an established AR rat model. Employing a true-experimental, post-test-only control group design, 25 male Wistar rats were randomized into five groups: negative control, positive control (OVA-induced AR), and three treatment arms receiving 10, 25, or 80 mg/kg body weight of extract over 16 days. Serum histamine was quantified via ELISA, and data were subjected to Kruskal-Wallis analysis with subsequent Dunn-Holm corrected Mann-Whitney tests; dose-response was further evaluated using the Jonckheere-Terpstra test. Statistically significant intergroup differences were observed (H = 22.347; p < 0.001), with the positive control group exhibiting the highest histamine levels (33.0 ng/mL). Treatment groups demonstrated a progressive reduction in histamine (29.4, 25.4, and 19.0 ng/mL), with the 80 mg/kg dose yielding a 42.4% decrease relative to control (p = 0.011). The presence of a significant dose-dependent trend (p = 0.031) underscores the potential of red apple peel extract as a cost-effective adjunctive strategy in AR management.
Co-Authors Arindo Kusuma Indra Setiawan Miftha Churochman Tara Mandirica