According to the World Health Organization (WHO), stroke remains the foremost cause of disability globally and ranks as the second leading cause of mortality. The progression of disability post-stroke is influenced by multiple interrelated factors, including advanced age, pre-existing comorbidities, cognitive dysfunction, and the initial severity of stroke at the time of onset. Various therapeutic approaches, including physical therapy to enhance muscle strength and coordination, occupational therapy to develop skills for performing daily activities, and psychosocial support, are essential components of rehabilitation programs aimed at improving the quality of life for stroke patients Objective this research for analyze the effectiveness of mindfulness therapy as part of ischemic post- stroke rehabilitation strategies in improving patients' quality of life and independence. Methods this research is A systematic review was conducted on studies published between 2020 and 2024. The search terms included: "Ischemic Stroke" OR "Strokes" OR "Cerebrovascular Accident" OR "CVA" OR "CVA's" AND "Disability" AND "Rehabilitation" OR "Rehabilitations Therapy" OR "Exercise Therapy”.Data identified from Pubmed 367, Semantic Scholar 287, Google Scholar 525, Science Direct 338, total number of articles used was 1517. Studies included in review 13 articles met the inclusion criteria and were deemed of sufficient quality. Eleven studies are RCT design, one study is One group pre- test post-test, and one study is quasi experiment design. Effective stroke rehabilitation requires a multidimensional approach that integrates physical exercise, community-based rehabilitation, technological innovations, and nursing interventions to enhance motor function, independence, and quality of life, with future research needed to evaluate long-term outcomes and personalized strategies.