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All Journal Jurnal Skala Kesehatan JPP Jurnal Kesehatan Poltekkes Palembang
Ni Nyoman Ariwidiani
Universitas Bima Internasional MFH Mataram
Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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High Sensitivity C-Reaktive Protein (Hs-CRP) dan LED sebagai Penanda Inflamasi pada Penderita Tuberculosis (TBC) Ni Nyoman Ariwidiani
Jurnal Skala Kesehatan Vol. 17 No. 2 (2026): Jurnal Skala Kesehatan Edisi Juli 2026 (In progress)
Publisher : Politeknik Kementerian Kesehatan Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/jsk.v17i2.531

Abstract

Mycobacterium tuberculosis infection increases IL-6 production, thereby inducing liver cells to synthesise active phase proteins, such as CRP. Increased levels of Hs-CRP and ESR are often associated with inflammation and acute infection. This study aims to determine the relationship between Hs-CRP and ESR levels as markers of inflammation in TB patients. Data collection was conducted using an analytical observational method with a cross-sectional design. Samples were obtained via simple random sampling, with a sample of 20 tuberculosis patients. Measurement of Hs-CRP levels was carried out using ELISA, while measurement of ESR levels was carried out using Roller 20. Data analysis was carried out using a statistical correlation test to determine the relationship between the two test variables. Based on the measurement data for Hs-CRP and ESR levels, the average Hs-CRP level was 3.32 mg/L, and the average ESR level was 54.55 mm/h in tuberculosis patients. Statistical correlation test shows the relationship between Hs-CRP levels and ESR in tuberculosis patients (p=0.042 with moderate correlation and positive correlation direction (t=0.458). Overall, there is a moderate, positive correlation between Hs-CRP levels and LED, a marker of inflammation, in tuberculosis patients.
Imunomodulator Zinc (Zn) Terhadap Pertumbuhan Parasitemia Pada Mencit BALB/C Yang diinfeksi Plasmodium Berghei ANKA Ni Nyoman Ariwidiani; Rosnalia Nyoman Widyan; Wulan Ratia Ratulangi
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 20 No 2 (2025): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v20i2.2975

Abstract

Background: Malaria infection is a disease with significant mortality, especially in tropical and subtropical areas. The rupture of infected red blood cells will stimulate the role of the immune system, CD4+ T cells will release IFN-γ cytokines that play a role in stimulating the activation of CD8+ T lymphocytes, which play a role in controlling parasitemia. Zinc is known to be involved in T cell signaling that can increase the expression of IFN-γ cytokines that play a role in parasite elimination. Methods: 20 minutes after being infected with P. berghei ANKA, were divided into 4 groups. Group 1-2 were given zinc as therapy with a concentration of 10mg/ml with a dose of 50mg/kgBW and 100mg/kgBW. Group 3 was a negative control (NC) given 0.5% sodium carboxylmethyl cellulose (CMCNa). Group 4 was a positive control treated with dihydroartemisinin-piperaquine (DHP) with a concentration of 187.2 mg/kgBW. Therapy was given for 4 days of observation, and parasitemia was observed every day after 24 hours of the first administration until the 4th day after administration. Results: Significant results were obtained in the parasitemia inhibition analysis after zinc administration on day 3 (p = 0.027) and day 4 (p = 0.001). Based on the results of the analysis, it was shown that zinc has anti-malarial activity that can inhibit the growth of parasitemia in test mice. Conclusion: Zinc as an antimalarial showed effectiveness in reducing parasitemia in BALB/c mice infected with P. berghei ANKA.
Co-Authors Rosnalia Nyoman Widyan Wulan Ratia Ratulangi