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All Journal EduInovasi: Journal of Basic Educational Studies Indonesian Journal of Global Health Research
Isti Noviani
Universitas Swadaya Gunung Jati
Religion Education Social Sciences Other

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Profil Nilai C-Reactive Protein (CRP) pada Pasien Tuberkulosis Paru dan Tuberkulosis Ekstra Paru di RSUD Waled Nova Nova; Isti Noviani; Dwi Rosa Eka Agustina
EduInovasi:  Journal of Basic Educational Studies Vol. 6 No. 2 (2026): EduInovasi:  Journal of Basic Educational Studies
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/edu.v6i2.11901

Abstract

Tuberculosis is a chronic infectious disease caused by the bacterium Mycobacterium tuberculosis. Based on the infected organ, tuberculosis is divided into extra-pulmonary tuberculosis and pulmonary tuberculosis (TB). C-Reactive Protein (CRP) is a protein found in the blood that increases in response to inflammation. CRP can be used as a marker of tuberculosis activity and severity and can predict the course of the disease. To determine profile of c-reactive protein (crp) values in tb & ekstrapulmonary tb patients at rsud waled. This observational study used a cross sectional design. Samples were taken from medical records using a Total Sampling within 100 patients. The research conducted at Waled hospital in June 2024. The resulted showed that the majority of CRP levels increased in 44 pulmonary TB patients (48.9%) and 8 extrapulmonary TB patients (80%). CRP levels increased in 24 adult pulmonary TB patients (26.7%), 20 elderly pulmonary TB patients (22.2%), while in adult and elderly extrapulmonary TB patients there were 4 people each (40%). CRP levels increased in 27 male pulmonary TB patients (30%), 17 female pulmonary TB patients (19%), while in 5 male extrapulmonary TB patients (50%) and 3 female patients (30%). C-Reactive protein level of pulmonary TB higher than extra pulmonary TB.
Correlation of Leukocyte Count and Degree of Thrombocytopenia with Disease Severity in Patients with Dengue Hemorrhagic Fever Hospitalized Habil Algadrie; Isti Noviani; Mohamad Luthfi
Indonesian Journal of Global Health Research Vol. 8 No. 6 (2026): Indonesian Journal of Global Health Research: December 2026
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i6.2585

Abstract

Dengue hemorrhagic fever remains a major health problem requiring appropriate clinical and hematological monitoring. Abnormal leukocyte and platelet counts are frequently observed in affected patients, but evidence regarding their correlations with disease severity remains inconsistent. To determine the correlations of leukocyte count and degree of thrombocytopenia with disease severity among patients with dengue hemorrhagic fever hospitalized at Waled Regional General Hospital in 2025. This observational analytic study used a retrospective cross-sectional design based on medical record data. A total of 204 patients were selected through consecutive sampling. Leukocyte and platelet counts were obtained from the first complete blood count at hospital admission, while disease severity was classified according to the 2009 WHO criteria. Bivariate analysis was performed using the Spearman rank correlation test.The largest age group was children aged 6–11 years, comprising 93 patients (45.6%), and most patients were male, comprising 107 patients (52.5%). Leukopenia was found in 90 patients (44.1%), moderate thrombocytopenia in 60 patients (29.4%), and dengue with warning signs in 115 patients (56.4%). No statistically significant correlation was found between leukocyte count and disease severity (r = 0.017, p = 0.809). A statistically significant weak positive correlation was found between the degree of thrombocytopenia and disease severity (r = 0.377, p < 0.001). Leukocyte count was not significantly correlated with disease severity, whereas the degree of thrombocytopenia showed a statistically significant weak positive correlation. Greater thrombocytopenia severity tended to be associated with greater disease severity.
Co-Authors Dwi Rosa Eka Agustina Habil Algadrie Mohamad Luthfi Nova Nova