This research is motivated by the low level of student learning independence in the learning process, which is indicated by the lack of initiative, self-confidence, discipline, and responsibility of students in learning. In addition, the low awareness of students in utilizing digital media or technology also causes limited interaction between teachers and students. This shows that the use of digital learning media is not fully effective in increasing student learning independence, because students' self-awareness in managing time, responsibility, and motivation for independent learning still need to be improved. The purpose of this study was to determine the effectiveness of the use of digital learning media on student learning independence in the excretory system material. This type of research is a quasi-experimental design. The population of this study was all 72 students of class XI MIA 1 and 2, and the sample used was also 72 students of class XI MIA 1 and 2. The data collection technique used a learning independence questionnaire, which consisted of 25 pretest and posttest statements. The data obtained were then analyzed using the SPSS 22.0 application for windows. Based on the results of the Analysis of Covariance (ANCOVA) test, the effectiveness value obtained was 0.001 < 0.05. It can be concluded that digital learning media such as learning videos provide effectiveness towards the learning independence of grade XI high school students in biology subjects. This shows that the use of digital learning media such as learning videos has a positive effect and can improve students' independent learning abilities, increase initiative and creativity, and facilitate students to have a better understanding of the learning concepts taught.