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All Journal Journal of Food and Pharmaceutical Science Journal of Pharmaceutical and Sciences. Journal of Food and Pharmaceutical Sciences Jurnal Info Kesehatan
Hestiary Ratih
Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi, West Java, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Optimization of Kefir Tablet Formulation using Acacia Gum as A Natural Binding Agent Hestiary Ratih; Ridha Dwita Putri; Slamet Ibrahim; Mira Andam Dewi
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26798

Abstract

Kefir enriched with Lactic Acid Bacteria (LAB) potentially has excellent health benefits as a probiotic beverage but its stability in liquid forms is limited. In order to attain stabilization and standardization of appropriate doses, kefir was converted to powders and subsequently formed into tablets using the wet granulation method after spray drying. This study aimed to optimize the formulation by comparing three concentrations of gum acacia (F1: 5%, F2: 10%, F3: 15%) as a natural binder and protective agent. Granule evaluation confirmed all formulations had low moisture content and good flow properties, with F3 exhibiting the best compressibility index (12.78%). Tablet evaluation showed all formulations met the friability (≤ 1%) and disintegration time (≤ 15 minutes) requirements. For tablet hardness, only F2 and F3 met the specification (≥ 4 kP), with F3 achieving the highest value (6.12 ± 0.09 kP). LAB viability showed a positive correlation with binder concentration, with F3 producing the highest colony count (709 ± 1.4 x 107 CFU/g). Throughout, F3 was able to produce the best quality intact matrices, extensive protective matrices, and outstanding viability among the LAB, F3 has pronounced to be the most propitious to be a very stable probiotic nutraceutical formulation.
Optimization of Kefir Tablet Formulation using Acacia Gum as A Natural Binding Agent Hestiary Ratih; Ridha Dwita Putri; Slamet Ibrahim; Mira Andam Dewi
Journal of Food and Pharmaceutical Sciences Vol 14, No 3 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26798

Abstract

Kefir enriched with Lactic Acid Bacteria (LAB) potentially has excellent health benefits as a probiotic beverage but its stability in liquid forms is limited. In order to attain stabilization and standardization of appropriate doses, kefir was converted to powders and subsequently formed into tablets using the wet granulation method after spray drying. This study aimed to optimize the formulation by comparing three concentrations of gum acacia (F1: 5%, F2: 10%, F3: 15%) as a natural binder and protective agent. Granule evaluation confirmed all formulations had low moisture content and good flow properties, with F3 exhibiting the best compressibility index (12.78%). Tablet evaluation showed all formulations met the friability (≤ 1%) and disintegration time (≤ 15 minutes) requirements. For tablet hardness, only F2 and F3 met the specification (≥ 4 kP), with F3 achieving the highest value (6.12 ± 0.09 kP). LAB viability showed a positive correlation with binder concentration, with F3 producing the highest colony count (709 ± 1.4 x 107 CFU/g). Throughout, F3 was able to produce the best quality intact matrices, extensive protective matrices, and outstanding viability among the LAB, F3 has pronounced to be the most propitious to be a very stable probiotic nutraceutical formulation.
Formulation Strategy to Prevent Sticking in Calcium Carbonate–Cholecalciferol Chewable Tablets: The Role of Citric Acid Hestiary Ratih; Oke Setiawan Gosepa; Fikri Alatas; Titta Hartyana Sutarna
JURNAL INFO KESEHATAN Vol 24 No 1 (2026): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol24.Iss1.2325

Abstract

The sticking phenomenon is a critical issue in the production of calcium carbonate–cholecalciferol (vitamin D3) chewable tablets, primarily driven by the hygroscopicity and reactivity of citric acid, which is used as a flavor-masking agent. This study aims to evaluate and determine the optimal method for mitigating sticking by modifying citric acid excipients using two approaches: granulation with mannitol (F1: 0.5%, F2: 1%) and coating with HPMC (F3: 0.5%, F4: 1%). The evaluation was conducted on the properties of the granule mass and quantitatively measured the percentage of sticking in industrial-scale modifications for 24 hours. The results showed that the control formula (F0), without modification, had the lowest sticking percentage (10.88%) and the highest moisture content (3.36%), as indicated by a "passable" flow property with a compressibility index of 21.47%. The 1% HPMC coating modification method (F4) was successful in eliminating stickiness to 0%, supported by moisture-control data (2.25%) and a significant improvement in powder-flow properties to “fair,” with a compressibility index of 17.06%. Although the 1% mannitol granulation method (F2) is relatively effective in reducing stickiness (0.85%), the 1% HPMC coating (F4) is more effective at physically isolating citric acid. This study concludes that the HPMC coating method is superior to the granulation method for physically isolating citric acid, yielding stable, non-sticking calcium carbonate–cholecalciferol chewable tablets.      
Optimasi Konsentrasi BHT untuk Menjaga Stabilitas Pigmen Alami pada Sediaan Cream Blush Ekstrak Hemigraphis colorata Hestiary Ratih; Titta Hartyana Sutarna; Nur Achsan Al-Hakim; Anisa Dwijayanti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1139

Abstract

The use of natural dyes from Hemigraphis colorata Hall. extract as cosmetic dyes faces stability challenges due to oxidative degradation. This study aims to test the effect of Butylated Hydroxytoluene (BHT) antioxidant concentration on the physical stability and color of cream blush formulations. H. colorata leaves were extracted by maceration and lyophilization, then formulated into four cream blush preparations with varying concentrations of BHT: without BHT (F0), 0.0075% (F1), 0.05% (F2), and 0.1% (F3). Physical stability of the formulations was evaluated for 28 days through organoleptic testing, homogeneity, pH, viscosity, spreadability, adhesion, and color stability using UV-Visible spectrophotometry. The results showed that all formulations met the physical standards for topical preparations. However, F2 (0.05%) and F3 (0.1%) successfully maintained color stability with minimal shifts. This study concludes that BHT can effectively maintain the physical stability of cream blush formulations based on H. colorata extract, with 0.05% (F2) being the optimal BHT concentration (the lowest effective concentration), based on considerations of effectiveness, safety, and cost, proven to be optimal in protecting natural pigments from degradation. These results provide important information for the development of safe, high-quality natural cosmetic products with a longer shelf life.
Co-Authors Anisa Dwijayanti Fikri Alatas Hartyana Sutarna, Titta Mira Andam Dewi Nur Achsan Al-Hakim Oke Setiawan Gosepa Ridha Dwita Putri Slamet Ibrahim