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All Journal Eureka Herba Indonesia Sriwijaya Journal of Obstetrics and Gynecology Crown: Journal of Dentistry and Health Research
Indri Yani Septiana
Department of Physiology, CMHC Research Center, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Peer-Led Nutritional Education Plus Iron-Folic Acid for Adolescent Iron-Deficiency Anemia: A Cluster Randomized Controlled Trial in Indonesia Indri Yani Septiana; Annisa Annisa
Sriwijaya Journal of Obstetrics and Gynecology Vol. 3 No. 2 (2025): Sriwijaya Journal of Obstetrics & Gynecology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjog.v3i2.279

Abstract

Introduction: Iron-deficiency anemia affects roughly one-third of adolescent girls and, by entering reproductive life with depleted iron stores, propagates intergenerational maternal risk. Standard weekly iron-folic acid (IFA) supplementation is undermined by poor adherence. We evaluated whether adding a peer-led nutritional-education program to IFA improves hematologic and psychosocial outcomes more than IFA alone. Methods: In a single-blind, parallel-group cluster randomized controlled trial in urban Palembang, Indonesia, 16 school clusters were randomized 1:1 to peer-led education plus weekly IFA (60 mg iron, 2.8 mg folic acid) or IFA alone. We enrolled 320 post-menarcheal girls aged 13–17 years with baseline hemoglobin 8.0–11.9 g/dL. Co-primary outcomes were hemoglobin and serum ferritin; the secondary outcome was the WHO-5 Well-Being Index, assessed at baseline, 3 and 6 months. Generalized linear mixed models with cluster random intercepts (intention-to-treat) were used. Results: At 6 months the intervention produced adjusted mean differences of +1.42 g/dL hemoglobin (95% CI 1.05–1.79; Cohen's d 2.11), +13.5 µg/L ferritin (10.2–16.8; d 2.75) and +23.4 WHO-5 points (19.8–27.0; d 3.14), all p<0.001. Anemia resolved in 89.3% versus 33.1% (RR 2.70, 95% CI 2.13–3.42; NNT 2). Adherence was higher with the intervention (92.5% vs 74.3%; OR 4.25). The multivariable model discriminated resolution well (AUC 0.89, 0.85–0.93). No severe adverse events occurred. Conclusion: A peer-led nutritional-education program markedly enhanced the efficacy of standard IFA, normalizing hemoglobin, replenishing iron stores and improving psychosocial well-being in anemic adolescent girls. This low-cost, scalable, school-based strategy is a promising preconception reproductive-health intervention for Indonesia and similar settings.
Network-Pharmacology-Guided Validation of Phyllanthus niruri Nephroprotection Against Doxorubicin: An In Vitro–In Vivo Translational Study Rachmat Hidayat; Vania Delma; Indri Yani Septiana
Eureka Herba Indonesia Vol. 6 No. 2 (2025): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v6i2.140

Abstract

Doxorubicin is a corner-stone anthracycline chemotherapeutic whose clinical utility is constrained by dose-limiting nephrotoxicity, and no approved pharmacological prevention currently exists. Phyllanthus niruri L. (Family Phyllanthaceae) — locally known in Indonesia as meniran — is a phytotherapeutic herb whose constituents (phyllanthin, hypophyllanthin, quercetin, rutin, gallic acid, and corilagin) target oxidative-stress and inflammatory pathways implicated in doxorubicin renal injury. We applied a tiered translational design: (i) network-pharmacology discovery using SwissTargetPrediction, TCMSP, GeneCards, and OMIM intersected six P. niruri active compounds with 842 nephrotoxicity-associated genes, identifying six hub targets (TNF, IL6, NFKB1, CASP3, BAX, BCL2) and four enriched KEGG pathways (TNF signaling, MAPK, PI3K-Akt, Apoptosis); (ii) in vitro validation in HK-2 human proximal tubular cells exposed to doxorubicin (2 µM, 24 h) with or without standardised P. niruri 70% ethanolic extract (25, 50, 100 µg/mL); and (iii) in vivo validation in 48 male Sprague-Dawley rats (eight per arm) given a single intraperitoneal dose of doxorubicin (15 mg/kg) and oral P. niruri at 100, 200, or 400 mg/kg/day for 14 days. P. niruri produced a dose-dependent rescue of HK-2 viability (84.6% at 100 µg/mL versus 41.8% in doxorubicin-only controls; p < 0.001) and reduced serum creatinine, blood urea nitrogen, urinary KIM-1, and NGAL by 55–70% at the 400 mg/kg dose with concordant restoration of glutathione and superoxide dismutase. Network-pharmacology hub targets showed transcriptionally coherent modulation. The findings support standardised P. niruri ethanolic extract as a mechanism-anchored herbal candidate for adjunctive prevention of doxorubicin-induced kidney injury, warranting clinical translation.
Clinical and Inflammatory Efficacy of a Novel Bioactive Borate Glass Air-Abrasion Powder for Peri-implant Mucositis Treatment: A Split-Mouth Randomized Controlled Clinical Trial Nur Diana; Indri Yani Septiana; Aprilia Sari; Michelle Birne
Crown: Journal of Dentistry and Health Research Vol. 3 No. 1 (2025): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v3i1.235

Abstract

Introduction: Peri-implant mucositis (PIM) is a prevalent inflammatory condition requiring effective biofilm management. This study aimed to evaluate the clinical and inflammatory efficacy of a novel bioactive borate glass (BBG) air-abrasion powder compared to a standard glycine-based powder for treating PIM. Methods: This was a split-mouth randomized controlled trial conducted at Palembang, Indonesia. Forty-two patients with two implants each, both diagnosed with PIM (Bleeding on Probing [BOP] positive, Probing Pocket Depth [PPD] 4 mm), were enrolled. In each patient, one implant site was randomly assigned to receive sub- and supragingival air-abrasion with the BBG powder (Test Group), while the contralateral implant received treatment with glycine powder (Control Group). Clinical parameters, including Modified Plaque Index (mPI), Modified Gingival Index (mGI), PPD, and BOP, were recorded at baseline (T0), 4 weeks (T1), and 12 weeks (T2). Peri-implant sulcular fluid (PISF) was collected to quantify levels of Interleukin-1 Beta (IL-1β) and Tumor Necrosis Factor-Alpha (TNF-α). Patient-reported discomfort was assessed using a Visual Analog Scale (VAS). Results: Both groups showed significant improvements in all clinical parameters from T0 to T2 (p < 0.001). At the 12-week follow-up (T2), the Test group demonstrated a statistically significantly greater reduction in mean PPD (Test: 1.21 + 0.28 mm vs. Control: 0.83 + 0.31 mm; p < 0.001) and a higher percentage of BOP resolution (Test: 88.1% vs. Control: 66.7%; p = 0.012). Furthermore, the reduction in IL-1β and TNF-α concentrations from T0 to T2 was significantly greater in the BBG group (p < 0.01 for both). Both treatments were well-tolerated with low VAS scores. Conclusion: Within the limitations of this study, non-surgical treatment of peri-implant mucositis using the novel bioactive borate glass air-abrasion powder resulted in superior clinical and inflammatory outcomes compared to standard glycine powder. This bioactive approach presents a promising advancement in peri-implant maintenance therapy.
Co-Authors Annisa Annisa Aprilia Sari Michelle Birne Nur Diana RACHMAT HIDAYAT Vania Delma