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All Journal JURNAL FARMASIMED (JFM) Jurnal Medika Nusantara
Amalia Nurul Ulum
Rumah Sakit Umum Daerah dr. Gondo Suwarno
Health Professions Medicine & Pharmacology Nursing Public Health

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Antibiotic Use in Inpatients with Diarrhea in Children: A Quantitative Evaluation at Hospital X, Semarang Regency, 2023 Zulfia Widiastuti; Avianti Eka Dewi Aditya Purwaningsih; Amalia Nurul Ulum
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/s8qfqn40

Abstract

Background : Infection remain one of the leading causes of morbidity in tropical regions such as Indonesia, with Escherichia coli being one of the most freequently identified pathogens. The high incidence of Escherichia coli-related infections has led to increased antibiotics use, considering that this commensal gut bactericum can cause both asymptomatic infections and symtomatic diarrhe, either bloody or non-bloody. Objective : This study aimed to evaluate use in pediatric patiens with diarrea at Hospital X, Semarang Regency, in 2023. Methods: This was a retrospective study uutilizing medical records of 323 pediatric patiens who met the inclusion and exclusion criteria. Data analysis was performed using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology. Result:The analysis revealed that Ceftriaxone injection was the most frequently used antibiotic (61.95%), followed by Ampicillin, Amikacin, Gentamicin, and Cefotaxime. Ceftriaxone was often prefered due to its efficacy against both gram-positive and gram-negative bacteria comonly associated with pediatric diarrhea, as well as the advantage of accurate dosing trough injectable formulations. Most diarrhea cases occurred in boys (62.54%) and in children under five years of age (65.63%). Conclusion:Injectable formulations were chosen to reduce the risk of vomiting and to facilitate precise and effective dosing. Evaluation using the ATX/DDD method highlighted the need for more rational antibiotic management to prevent bacterial resistance in the future. Optimizing antibiotic stewardship is crucial to ensure targeted in the future. Optimizing antibiotic stewardship is crucial to ensure targeted, effective use and to preserve therapeutic efficacy in the long term. 
Penggunaan Obat Gabapentin pada Pasien Nyeri Neuropati Diabetik Rawat Jalan di RSUD Dr. Gondo Suwarno Kabupaten Semarang Siti Risma Wati; Avianti Eka Dewi Aditya Purwaningsih; Amalia Nurul Ulum
Jurnal Medika Nusantara Vol. 4 No. 4 (2026): : Jurnal Medika Nusantara
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v4i4.2883

Abstract

Diabetic neuropathic pain is a chronic complication of diabetes mellitus that can significantly reduce patients' quality of life due to persistent pain, sleep disturbances, and limitations in daily activities. Gabapentin is one of the drugs used to treat neuropathic pain, but the effectiveness of its use in outpatients at Dr. Gondo Suwarno Regional General Hospital, Semarang Regency, had never been studied. This study aimed to determine the effectiveness of gabapentin in reducing diabetic neuropathic pain in outpatients at Dr. Gondo Suwarno Regional General Hospital, Semarang Regency. This was an observational study with a prospective design. The observed variables included patient characteristics, dose, and changes in pain complaints before and after therapy. Data were analyzed descriptively to describe the effectiveness of gabapentin therapy in reducing pain complaints in diabetic neuropathy patients. The mean difference in pain scores before and after therapy is 2.34 for gabapentin 100 mg (50 patients), 2.6 for gabapentin 200 mg (43 patients), 3 for gabapentin 300 mg (60 patients), and 2.8 for gabapentin 600 mg (7 patients). The degree of pain decreases after gabapentin administration. Based on clinical assessment, gabapentin 300 mg gives a better pain outcome than the other doses in treating patients at the neurology clinic of Dr. Gondo Suwarno Hospital. There is a significant improvement in the degree of pain before and after gabapentin administration. These findings can serve as preliminary data on the clinical benefits of gabapentin and as a basis for developing neuropathic pain therapy at this hospital.
Co-Authors Purwaningsih, Avianti Eka Dewi Aditya Siti Risma Wati Zulfia Widiastuti