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All Journal Indonesia Natural Research Pharmaceutical Journal (INRPJ) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL
Dewi Rahmawati
Jakarta Global University
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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IN SILICO ANALYSIS OF SAGA SEED EXTRACT (Abrus precatorius L.) FOR ANDROGENIC ALOPECIA TREATMENT Dewi Rahmawati; Rizky Farmasita Budiastuti; Ashfar Kurnia
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 11, No 1 (2026)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v11i1.8773

Abstract

Androgenic alopecia (AGA) is a genetically determined hair loss condition. In men, hair loss is influenced by androgen hormones, whereas in women, androgenic alopecia is thought to be influenced by genetic factors. Currently, several drugs are used in the treatment of AGA, including 5α-reductase inhibitors, minoxidil, finasteride, and dutasteride for androgen-related disorders. However, the use of these medications may cause various undesirable side effects, such as impotence, abnormal ejaculation, decreased ejaculate volume, sexual dysfunction, gynecomastia, testicular pain, reduced muscle growth, and severe myopathy. The use of natural products as hair growth agents has been widely investigated, and several herbal extracts have been reported to be effective in the management of androgenic alopecia, one of which is saga seed extract. Saga seeds have been reported to contain campesterol, cholesterol, palmitic acid, lignoceric acid, oleic acid, linoleic acid, linolenic acid, cycloartenol, beta-amyrin, β-sitosterol, stigmasterol, trigonelline, and brassicasterol (1)). This in silico study was conducted to evaluate the potential of β-sitosterol, stigmasterol, and brassicasterol present in saga (Abrus precatorius L.) seed extract compared with the positive control, minoxidil. Molecular docking analysis using Molegro Virtual Docker based on rerank score values demonstrated that brassicasterol exhibited better binding potential than β-sitosterol, stigmasterol, and the positive control minoxidil.
PENGARUH KONDISI KELEMBABAN LEMBAB DAN KERING TERHADAP JUMLAH DAN VIABILITAS SEL PUNCA MESENKIMAL PADA PASASE 6-9 Galuh Rismawan; Dewi Rahmawati; Rizky Farmasita Budiastuti
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.8960

Abstract

Penelitian ini bertujuan untuk mengevaluasi pengaruh kondisi kelembaban inkubator terhadap jumlah dan viabilitas sel punca mesenkimal (Mesenchymal Stem Cell, MSC) pada pasase 6 hingga 9. Dua kondisi fisiologis diuji, yaitu kultur dalam inkubator dengan kelembaban tinggi (RH ±95%) dan kelembaban rendah (RH <80%) pada kondisi normoksia (37°C, 5% CO₂). Sel yang digunakan merupakan MSC manusia yang diperoleh dari jaringan lemak donor dewasa dan telah dikarakterisasi positif terhadap penanda CD73, CD90, dan CD105. Proses kultur dilakukan secara aseptis dengan media a-MEM yang diperkaya Human Platelet Lysate (HPL) serta antibiotik 1% penicillin-streptomycin. Parameter yang diukur meliputi jumlah total sel, viabilitas sel menggunakan pewarnaan Trypan Blue, dan Population Doubling Time (PDT). Hasil menunjukkan bahwa kelembaban tinggi memberikan hasil yang signifikan terhadap peningkatan jumlah sel dan viabilitas (p<0,05). Rata-rata jumlah sel akhir pada kondisi lembab mencapai 23,36×10⁶ dengan viabilitas 90,23%, sedangkan pada kondisi kering hanya 5,56×10⁶ dengan viabilitas 81,13%. Perbedaan kelembaban juga memengaruhi PDT, di mana kondisi lembab menghasilkan pertumbuhan lebih cepat (0,33 hari⁻¹) dibandingkan kondisi kering (0,54 hari⁻¹). Dengan demikian, kelembaban tinggi berperan penting dalam menjaga stabilitas fisiologis dan mempercepat proliferasi MSC in vitro.
Co-Authors Ashfar Kurnia Galuh Rismawan Rizky Farmasita Budiastuti Rizky Farmasita Budiastuti