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All Journal Journal of Natural Sciences and Mathematics Research Andan Jejama: Indonesian Journal Of Community Engagement
Annisa Ananda
Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Materials Science & Nanotechnology Physics Public Health

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Edukasi PHBS melalui Cuci Tangan dan Pengelolaan Sampah di UPTD SDN 39 Gedong Tataan Annisa Ananda; Widyastuti; Rohimatul Anwar
ANDAN JEJAMA: Indonesian Journal of Community Engagement (IJCE) Vol. 5 No. 1 (2026): Indonesian Journal of Community Engagement (IJCE) ANDAN JEJAMA
Publisher : FMIPA Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/ijceaj.v5i1.70

Abstract

Penerapan perilaku hidup bersih dan sehat (PHBS) pada anak usia sekolah dasar merupakan salah satu upaya penting dalam pencegahan penyakit menular di lingkungan sekolah. Namun, masih ditemukan rendahnya kesadaran siswa mengenai praktik cuci tangan yang benar dan pentingnya membuang sampah pada tempatnya. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pemahaman siswa sekolah dasar mengenai perilaku hidup bersih dan sehat melalui edukasi cuci tangan dan pengelolaan sampah sederhana. Kegiatan dilaksanakan dalam bentuk penyuluhan, demonstrasi langkah cuci tangan yang benar, diskusi interaktif, serta pemberian media edukasi berupa poster tahapan cuci tangan dan tempat sampah untuk setiap ruang kelas. Hasil kegiatan menunjukkan antusiasme tinggi siswa serta kemampuan menjawab pertanyaan terkait materi yang diberikan. Kegiatan ini berkontribusi dalam meningkatkan kesadaran siswa terhadap pentingnya menjaga kebersihan diri dan lingkungan sekolah.
In silico physicochemical and drug-likeness assessment of Indoloquinoxaline Derivatives as potential Anti-Alzheimer Agents Noor Dienna Annisha; Alfa Zihni Adzaky; David Ardiansyah; Annisa Ananda; Muhammad Zulqurnain
Journal of Natural Sciences and Mathematics Research Vol. 12 No. 1 (2026): June
Publisher : Faculty of Science and Technology, Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/jnsmr.v12i1.32090

Abstract

Alzheimer’s disease (AD) remains a major progressive neurodegenerative disorder with limited therapeutic efficacy, primarily targeting acetylcholinesterase (AChE), with significant challenges related to Blood-Brain Barrier (BBB) penetration. This study aimed to perform drug likeness screening, ADMET profiling, and BBB penetration prediction of indoloquinoxaline derivatives as potential CNS-active anti-Alzheimer candidates using SwissADME as the sole computational platform. A total of 36 compounds, comprising 31 indoloquinoxaline derivatives and five reference anti-Alzheimer drugs, were analyzed in silico using five pharmacokinetic filters (Lipinski, Ghose, Veber, Egan, and Muegge), followed by lipophilicity assessment (Consensus LogP range: 2.59–5.39), molecular weight, rotatable bonds, hydrogen bonding, and medicinal chemistry evaluations. All 36 compounds fulfilled Lipinski and Veber criteria with 100% compliance, while Ghose, Egan, and Muegge filters identified 3, 2, and 8 violations, respectively, predominantly attributable to excessive lipophilicity in substituents such as –CF₃ and tert-butyl groups. The investigated compounds exhibited CNS-compatible MW (219.24–400.52 Da), LogP (2.88–4.95 for the majority), and TPSA (30.71–54.50 Ų) profiles. A total of 29 out of 31 synthesized compounds (93.5%) were predicted as BBB-permeant. In addition, all candidates showed zero PAINS alerts and predominantly zero Brenk alerts, indicating favorable medicinal chemistry characteristics and low risk of nonspecific bioassay interference. Several compounds demonstrated physicochemical properties comparable to clinically approved anti-Alzheimer drugs (donepezil, galantamine, rivastigmine), suggesting promising potential for further AChE-targeted CNS drug development.
Co-Authors Alfa Zihni Adzaky David Ardiansyah Muhammad Zulqurnain Noor Dienna Annisha Rohimatul Anwar Widyastuti