Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmako Bahari Borneo Journal of Pharmacy
Nuri Ari Efiana
Universitas Ahmad Dahlan
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Formulasi dan Karakterisasi Nanoserum Kombinasi Ekstrak Wortel (Daucus carota L.) dan Astaxanthin sebagai Antioksidan Tiara Bella Pratiwi; Arif Budi Setianto; Nuri Ari Efiana; Sri Mulyaningsih
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.43464

Abstract

Lipophilic antioxidants such as β-carotene and astaxanthin have strong potential to protect the skin against oxidative stress; however, their topical application is limited by low stability and insufficient skin penetration. This study aimed to formulate and evaluate the physical characteristics, stability, and antioxidant activity of a nanoserum combining carrot extract (Daucus carota L.) and astaxanthin. Carrot extract was obtained by maceration using 96% ethanol and formulated into a nanoemulsion-based serum containing three extract concentrations: 5% (F1), 10% (F2), and 15% (F3), with 1% astaxanthin. The formulations were evaluated for organoleptic properties, particle size, polydispersity index (PDI), zeta potential, pH, viscosity, and adhesiveness. Stability was observed up to 6 days, while antioxidant activity was determined using ABTS and FRAP assays. All formulations exhibited nanoscale particle sizes with good homogeneity (PDI <0.5) and negative zp (<-30 mV), indicating stable dispersions. Formula F2 showed the most favorable characteristics, with a particle size of 39.21 ± 0.32 nm, PDI of 0.25 ± 0.02, and zeta potential of −33.66 ± 0.27 mV, along with suitable pH and viscosity for topical application. F2 demonstrated very strong antioxidant activity, with IC₅₀ values of 9.04 ± 0.19 ppm (ABTS) and 16.78 ± 0.04 ppm (FRAP), which remained in the strong category after storage. In conclusion, the carrot extract–astaxanthin nanoserum was successfully developed, with F2 identified as the optimal formulation.
Studies of the Physicochemical Properties, Stability, Irritability, and Efficacy of Red Boroco (Celosia argentea) Leaf Extract Patch for Diabetic Wound Healing Siti Fatmawati Fatimah; Nurul Safira Basuki; Nuri Ari Efiana
Borneo Journal of Pharmacy Vol. 9 No. 2 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i2.9974

Abstract

Red Boroco (Celosia argentea) leaves contain flavonoids that act as wound healers by promoting skin tissue repair and fibroblast growth. The 15% w/w C. argentea leaves extract was formulated into a patch for diabetic wound healing. This study aims to evaluate the physicochemical characteristics, physical stability, irritability, and efficacy of the C. argentea leaves extract patch for diabetic wound healing. Celosia argentea leaves were macerated in 70% ethanol, the flavonoid content was measured, and the extract was formulated into a patch. Evaluation of the patch included measurements of organoleptic properties, pH, weight uniformity, folding resistance, patch thickness, moisture content, and moisture uptake. A stability study was conducted using a freeze-thaw cycle method. The Hen's Egg Test-Chorioallantoic Membrane (HET-CAM) to confirm the irritability of the patch. The efficacy study was conducted by measuring the percentage of wound closure in male Wistar rats. The results showed that C. argentea leaves contained 1.101 ± 0.012 μg QE of flavonoids. The patch characteristics were as follows: pH 6.16 ± 0.01; weight uniformity 0.513 ± 0.038 g; folding resistance >300 folds; patch thickness 0.4 mm; moisture content 0.031 ± 0.028%; and moisture uptake 0.030 ± 0.009%. Statistical analysis (unpaired t-test) showed no significant changes in physical properties after the freeze–thaw cycle (p >0.05), indicating good stability. The one-way ANOVA test of wound closure showed no significant difference between the patch group and the positive control group (p = 0.948). Patch exhibited good physical stability, no irritation, and an 89.88% wound-healing rate in the test animal.
Co-Authors Arif Budi Setianto Nurul Safira Basuki Siti Fatmawati Fatimah Sri Mulyaningsih Tiara Bella Pratiwi