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All Journal International Journal of Public Health Science (IJPHS) Proceedings of KNASTIK Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Science and Technology Indonesia Communications in Science and Technology Jurnal Kebidanan JFL : Jurnal Farmasi Lampung KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Indonesia Berdaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sehat Indonesia (JUSINDO)
Arif Budi Setianto
Universitas Ahmad Dahlan
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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INDENTIFIKASI IRITASI KULIT MANUSIA MENGGUNAKAN METODE JARINGAN SARAF TIRUAN LEARNING VECTOR QUANTIZATION Fadlil, Abdul; Setianto, Arif Budi; Purnamasari, Putri
Proceedings of KNASTIK 2010
Publisher : Duta Wacana Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Jaringan saraf telah berhasil dipakai dalam bidang klasifikasi pola. Makalah ini menyajikan suatu metode baru untuk mengidentifikasi Iritasi kuit manusia. Metodologi yang diusulkan menggunakan jaringan saraf learning vector quantization sebagai pengklasifikasi untuk pengidentifikasi kulit manusia. Normalisasi histogram dari citra kulit digunakan sebagai vektor ekstraksi ciri untuk membedakan antara pola non iritasi dan pola iritasi. Sistem identifikasi ini dilatih menggunakan sekumpulan data citra kulit non-iritasi dan iritasi masing-masing 10 citra. Selanjutnya diuji dengan data citra kulit non-iritasi dan iritasi masing-masing 12 citra. Hasil-hasil percobaan kami menunjukkan bahwa unjuk kerja sistem cukup akurat yaitu 83,3%.
Black cumin seed oil preparation consumption potentially improves adaptive cellular immune response among healthy volunteers Titiek Hidayati; Akrom Akrom; Arif Budi Setianto
International Journal of Public Health Science (IJPHS) Vol 11, No 2: June 2022
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v11i2.21425

Abstract

Oxidative stress and inflammatory reactions are the pathological mechanisms for most degenerative diseases. The black cumin seed oil (BCSO) contains compounds that can act as antioxidants and immunomodulators. Consuming BCSO is thought to improve antioxidant and immunomodulatory parameters in obese people. This study investigated the effect of BCSO consumption on antioxidant and immunomodulatory activity in healthy volunteers. We conducted a quasi-experimental study on 12 healthy volunteers in Yogyakarta, Indonesia. We asked the volunteers to consume BCSO for twenty days. We measured blood pressure, body mass index (BMI), malondialdehyde (MDA) level, Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT) activity, CD4Th, and IFN-γ expression before and after consuming BCSO. We carried out the average difference test of the parameters before and after consumption of BCSO by dependent t-test. The results showed that 3x1 BCSO preparation for 20 days reduced MDA levels and increased CDTh and IFN-γ. Consuming BCSO for 20 days potentially improve the adaptive cellular immune response parameters.
AKTIVITAS REPELLENT FORMULASI SEDIAAN SPRAY KOMBINASI MINYAK ATSIRI SERAI (Cymbopogon winterianus), DAUN KEMANGI (Ocimum basilicum) DAN NILAM (Pogostemon Cablin) BESERTA UJI PREFERENSINYA Faikah Dyah Utami; Arif Budi Setianto
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 1 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.085 KB) | DOI: 10.36387/jiis.v6i1.631

Abstract

Plants that are played as mosquito repellents, one of which is plants that contain essential oils, such as lemongrass, basil and patchouli. As an effort to make it easier to use, this research will make a spray repellent preparation with a combination of active ingredients from essential oils of lemongrass, basil and patchouli. The research methods included making a spray repellent using essential oils of lemongrass, basil, patchouli every 0.1 ml (5 concentrations %), 0.2 ml (10% concentration), 0.3 ml (15% concentration) and the additives 1ml Propylene glycol and 5 ml 96% Ethanol which functions as a solvent. The experiment used five treatments, namely: Negative control (Kn), Formula A (0.1ml), Formula B (0.2ml), Formula C (0.3ml), and Positive Control (Kp). The parameters tested included pH test, patch test, organoleptic, specific gravity, emulsion stability, preference and percentage of protective power. The protective power test was carried out 10 times from each treatment for 6 hours of observation (0-1 hours, 1-2 hours, 2-3 hours, 3-4 hours, 4-5 hours and 5-6 hours). The results showed that the best spray expulsion treatment was formula B with a concentration of 10% (0.2 ml)
OPTIMASI CAMPURAN AVICEL 101 DAN LAKTOSA SEBAGAI BAHAN PENGISI PADA TABLET DISPERSI PADAT TADALAFIL DENGAN METODE GRANULASI BASAH Mohamad Reski Manno; Arif Budi Setianto
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 2 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v19i2.6667

Abstract

INTISARI Pengembangan formula obat dalam industri farmasi sangatlah penting, dimana komposisi formula yang optimum dapat mempengaruhi sediaan farmasetis yang memenuhi persyaratan sesuai CPOB. Tadalafil merupakan obat yang berkhasiat sebagai terapi disfungsi ereksi yang diformulasikan dalam sediaan padat berupa tablet dengan metode granulasi. Penelitian ini bertujuan untuk mendapatkan formula optimum tablet dispersi padat tadalafil dengan campuran avicel 101 dan laktosa sebagai bahan pengisi dengan metode granulasi basah. Granul dispersi padat tadalafil dibuat dengan perbandingan kosentrasi bahan pengisi avicel 101 dan laktosa yaitu 5:5, 4:6, dan avicel 101 tanpa kombinasi laktosa. Evaluasi sediaan meliputi uji waktu alir granul, uji sudut diam, uji pengetapan, kadar air granul, uji kekerasan, uji keseragaman bobot, uji keseragaman ukuran, kerapuhan dan waktu hancur tablet. Hasil penelitian menunjukan bahwa formula dengan kombinasi avicel 101 dan laktosa sebagai bahan pengisi dapat menghasilkan formula granul dan tablet dengan karakteristik yang baik.Kata kunci: (Avicel 101, Granul, Laktosa, Tablet, Tadalafil)
Herbal supplementation improves clinical outcomes among diabetes mellitus patients Akrom Akrom; Titiek Hidayati; Arif Budi Setianto
International Journal of Public Health Science (IJPHS) Vol 12, No 2: June 2023
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v12i2.22534

Abstract

Hyperglycemic conditions are still common in diabetes melllitus (DM) patients with routine therapy. Rural communities in the Special Region of Yogyakarta habitually consume herbal medicines. Herbal nutritional supplements (MHM) were developed as additional therapy to increase the success of achieving therapeutic targets for DM patients. This study aimed to identify the clinical picture of DM patients who were given MHM at public health center (PHC) in the rural areas of Bantul Regency, Yogyakarta Special Region. This retrospective study was conducted on 94 DM patients with routine therapy. Patients who met the inclusion and exclusion criteria and had agreed to the informed consent were divided into two groups. Patients in the treatment group were asked to consume herbal supplement preparations (MHM) for 20 days. On day 21, each group measured clinical outcome parameters (blood pressure, blood glucose levels, triglycerides, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), liver enzymes, urea, and creatinine). The mean difference test between the two groups (t-test) was carried out using a 95% confidence level. The results showed that the consumption of MHM herbal nutritional supplements for 20 days reduced blood sugar levels, Hb A1C levels, and urea levels (p<0.05). There were no differences in blood pressure, pulse, cholesterol, triglyceride, HDL, LDL, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), and creatinine levels between the two groups (p>0.05). Administration of MHM for 20 days increased clinical outcomes in blood sugar, HbA1c, and urea levels in DM patients at PHC.
Peningkatan Pengetahuan dan Keterampilan Keluarga Aisyiyah Malaysia Dalam Pemanfaatan Rempah Secara Maksimal Yunda Maymanah Rahmadewi; Iis Wahyuningsih; Arif Budi Setianto
Indonesia Berdaya Vol 5, No 1 (2024)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.2024720

Abstract

Pimpinan Cabang Istimewa Aisyiyah (PCIA) Malaysia merupakan organisasi otonom Muhammadiyah yang mengakomodir potensi kaum ibu dan wanita dari kader, warga, simpatisan dan keluarga besar Aisyiyah di Malaysia. Tidak semua keluarga besar Aisyiyah memiliki pekerjaan yang tetap di Malaysia sehingga perlu tambahan dukungan ekonomi secara mandiri. Malaysia yang memiliki karakteristik geografis yang tidak berbeda jauh dengan Indonesia memiliki potensi tanaman yang serupa sehingga berpeluang dimanfaatkan oleh warga Aisyiyah dalam menjaga kesehatan secara mandiri melalui produk makanan maupun minuman. PkM ini bertujuan untuk meningkatkan pengetahuan dan ketrampilan Keluarga Aisyiyah Malaysia Melalui Keterampilan Pengolahan Herbal. Permasalahan diselesaikan dengan memberi pengetahuan dan ketrampilan mengolah Herbal. Metode pelaksanaan dilakukan dengan penyuluhan dan pelatihan dengan mitra sasaran yaitu Keluarga Aisyiyah Malaysia yang beranggotakan WNI dan warga negara Malaysia. Kegiatan penyuluhan dan pelatihan pemanfaatan rempah menghasilkan produk jamu beras kencur, permen marshmallow jahe, permen keras jahe, teh serai pandan, dan minuman serbuk jahe. Program ini dapat meningkatkan pengetahuan dan keterampilan masyarakat sasaran dalam pengolahan rempah
The Description of Knowledge and Attitude of Coffee Lovers on Diabetes Melitus At Coffee Shops In Palaran District: The Description of Knowledge and Attitude of Coffee Lovers on Diabetes Melitus At Coffee Shops In Palaran District Muhammad Ma'ruf; Arif Budi Setianto; Rindi Ibrahim Lasanudin; Sapto Yuliani
KESMAS UWIGAMA: Jurnal Kesehatan Masyarakat Vol 9 No 2 (2023): December
Publisher : Universitas Widya Gama Mahakam Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24903/kujkm.v9i2.2224

Abstract

Background: Diabetes mellitus is a disease that is often called "the silent killer." This disorder occurs in the metabolism of carbohydrates and fats that are relatively deficient in insulin in the body. Previous research said that coffee could be used as a therapy for diabetes mellitus. The background for writing this article is the high prevalence of knowledge and attitude of coffee lovers and scientific evidence of coffee content as a decrease in blood glucose levels. Objectives: This study aims to describe the knowledge and attitude of coffee lovers toward diabetes mellitus in coffee shops in Palaran District. Research Metodes: This research method uses quantitative and descriptive. Data were obtained by distributing questionnaires to research subjects, namely coffee lovers who were in coffee shops in the Palaran District, Samarinda City, totaling 46 respondents. Results: The results showed that there were 26 coffee lovers (56.5%) who had good knowledge of diabetes mellitus and 20 people (43.5%) who had a good understanding of diabetes mellitus. Meanwhile, in the attitude of coffee lovers, there were 35 people (76.1%) who had good attitude towards diabetes mellitus and 11 people (23.9%) who had a reasonably good attitude towards diabetes mellitus. Conclusion: It can be concluded that the coffee lovers in the Palaran District coffee shop, on average, have good knowledge and attitude towards diabetes mellitus.
The crystal packing and slip plane analysis in mechanical properties improvement of mefenamic acid by cocrystallization with nicotinamide coformer Ari Wahyudi; Utami, Dwi; Setianto , Arif Budi
Communications in Science and Technology Vol 5 No 2 (2020)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.5.2.2020.213

Abstract

Mefenamic acid is an analgesic non-steroidal anti-inflammatory drug (NSAID) that is categorized as Biopharmaceutical Classification System (BCS) class II drug. Cocrystallization of mefenamic acid (MFA) with nicotinamide (NIC) has been reported to enhance the solubility of MFA for about 2.56 times higher than pure MFA. As a part of MFA-NIC development in pharmaceutical dosage form, we reported the improvement of mechanical properties of MFA-NIC cocrystal based on the presence of slip planes in crystal structure. The research was initially by synthesizing and characterizing the cocrystal by using X-ray diffraction analysis, and was followed by the investigation of the mechanical properties of MFA and its cocrystal, i.e. tensile strength and deformation parameter. The correlation of crystal structure with mechanical properties was determined by crystal packing motif and slip plane analysis from single crystal data by using Mercury 3.6. The tensile strength of MFA was acceptance at 20.0 MPa, and dropped at more than 25.0 MPa. A better tableting performance was observed in MFA-NIC cocrystal which had the tensile strength 1.5 times higher than MFA at 12.5 MPa and gradually increased with an increasing pressure up to 2.5 times at 22.5 MPa. The flat slip plane of MFA-NIC cocrystal was predicted as the key factor in the improvement of its mechanical properties, compared to zigzag slip plane of MFA. In conclusion, MFA-NIC cocrystal had the better mechanical properties than pure MFA due to its flat slip plane and it becomes potential to be explored in further development of solid dosage form.
PENGARUH KOMBINASI MINYAK SEREH (Cymbopogon citratus) DAN MINYAK KEMANGI (Ocimum basilicum) TERHADAP SIFAT FISIK DEODORAN ROLL ON Hasan, Nuradnin; Setianto, Arif Budi; Mulyaningsih, Sri
Jurnal Kebidanan VOLUME 15, NO.02 Desember 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Estu Utomo Boyolali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35872/jurkeb.v15i02.677

Abstract

ABSTRAK Minyak sereh (Cymbopogon citratus) dan minyak kemangi (Ocimum basilicum) adalah minyak esensial yang dapat dimanfaatkan dalam formulasi sediaan kosmetik. Deodoran roll on merupakan jenis yang sangat fleksibel dan populer karena tidak berminyak saat digunakan. Penelitian ini bertujuan untuk mengetahui pengaruh komposisi dari kedua minyak terhadap sifat fisik sediaan deodoran roll on. Formulasi deodoran roll on mengandung 4% (b/v) komposisi minyak sereh dan minyak kemangi dalam tiga perbandingan yaitu F1 (1:3), F2 (2:2) dan F3 (3:1) yang dievaluasi sifat fisiknya antara lain organoleptik, viskositas dan ukuran partikel. Komposisi kedua minyak dapat mempengaruhi organoleptik, viskositas dan ukuran partikel sediaan deodoran roll on. Kata Kunci: Minyak sereh & Minyak Kemangi, Sediaan Deodoran Roll On ABSTRACT Lemongrass oil (Cymbopogon citratus) and basil oil (Ocimum basilicum) are essential oils that can be utilized in the formulation of cosmetic preparations. Roll on deodorant is a very flexible and popular type because it is not greasy when used. This study aims to determine the effect of the composition of the two oils on the physical properties of roll-on deodorant preparations. Roll-on deodorant formulations containing 4% (b/v) lemongrass oil and basil oil in three compositions, namely F1 (1:3), F2 (2:2) and F3 (3:1) were evaluated for physical properties including organoleptic, viscosity and particle size. The composition of the two oils can affect the organoleptic, viscosity and particle size of the roll on deodorant preparation. Keywords: Lemongrass Oil & Basil Oil, Roll-On Deodorant Preparation
Nanotechnology-Based Nanopolymeric Polyherbal Formulation for Enhanced Antioxidant and Anti-Glycation Activity Astuti, Febriana; Mustofa; Arif Budi Setianto; Akrom
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.972-981

Abstract

Elevated oxidative stress and glycation give to the enhancement of degenerative condition such as diabetes and heart disease. Herbal extracts such as Apium graveolens, Centella asiatica, and Orthosiphon stamineus possess well-documented antioxidant and anti-glycation properties. However, their therapeutic effectiveness is measured by poor bioavailability, highlighting the need for innovative formulations. Nanotechnology presents a indicative of success approach by improving the solubility and distribution of active compounds. This study developed a nanopolymeric formulation by combining extracts of Apium graveolens, Centella asiatica, and Orthosiphon stamineus utilizing the ionic gelation method by chitosan, NaTPP, and Tween 80. The nanoparticles were characterized based on particle size, PDI, zeta capability, TEM, and FTIR. In vitro assays utilizing peripheral blood mononuclear cells (PBMCs) were conducted to analyze antioxidant activity through Nrf2 and GST expression, and anti-glycation capability by measuring AGEs. The nanopolyherbal particles had an average size of 186 ± 46.81 nm, by a PDI of 0.434 ± 0.04 and a zeta capability of -29.69 ± 1.54 mV. Both 1% and 3% nanopolyherbal treatments increased Nrf2 stages (66.77 ± 7.65 and 63.13 ± 2.75, respectively) and GST stages (87.97 ± 49.48 and 73.57 ± 4.61) compared to the control group (Nrf2: 54.1 ± 1.0; GST: 68.93 ± 2.28). The nanopolyherbal formulation also significantly decreased AGE itemion (1%: 1075.67 ± 107.51; 3%: 813.33 ± 117.05) compared to the control (1497.33 ± 161.58). These outcomes reveal that the nanopolyherbal formulation enhances antioxidant activity and inhibits glycation in PBMCs, suggesting its capability for managing oxidative stress-related condition.
Co-Authors Abdul Fadlil Akrom, Akrom Ari Wahyudi Astuti, Febriana Capritasari, Rafiastiana Faikah Dyah Utami Hasan, Nuradnin Hasna, Elly Rosita Husain, Dewi Putri Iis Wahyuningsih Kintoko Mohamad Reski Manno Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mustofa Mustofa Nuradnin Hasan Putri Purnamasari Putri, Meilisa Rindi Ibrahim Lasanudin Sapto Yuliani Sri Mulyaningsih Sri Mulyaningsih Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Yunda Maymanah Rahmadewi