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All Journal Didaktik : Jurnal Ilmiah PGSD STKIP Subang Eduvest - Journal of Universal Studies
Harliansyah
Universitas YARSI
Aerospace Engineering Computer Science & IT Education Health Professions Neuroscience Social Sciences

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The Effect of Bajakah Wood Extract on Collagenase Activity of Glycated Proteins in Rats and its Review from an Islamic Perspective Ainuzzahra; Harliansyah; Nenden Lilis Setiasih; Luh Ade Lela Arika; Puput Putuh Anisa
Eduvest - Journal of Universal Studies Vol. 6 No. 5 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i5.52875

Abstract

Skin aging is a biological process that is influenced by oxidative stress and the accumulation of advanced glycation end products (AGEs) that can increase the activity of the collagenase enzyme so that it causes collagen degradation. Red logan wood (Spatholobus littoralis Hassk.) is known to have antioxidant content that has the potential to inhibit this process. This study aimed to determine the effect of administration of ethanol extract of red logs on collagenase activity in male white rats of the Sprague-Dawley strain induced by D-galactose. This study is a laboratory experimental research with a post-test only control group design. A total of 36 rats were divided into six groups, namely the blank group, negative control, positive control, and three treatment groups given red bajakah wood ethanol extract with doses of 25 mg/kgBB, 50 mg/kgBB, and 100 mg/kgBB. Induction of aging was carried out using D-galactose, then serum collagenase activity was measured using the ELISA method. Data were analyzed using a one-way ANOVA test followed by an LSD test with a significance level of p < 0.05. The results showed that the administration of ethanol extract of red logs was able to significantly reduce collagenase activity compared to the negative control group (p < 0.05). Doses of 100 mg/kgBB showed the greatest decreasing effect and were close to positive control groups. This suggests that red logwood extract has the potential to be a natural anti-aging agent through a mechanism of inhibition of collagen activity.
Peran Biomarker IL-1β, IL-6, TNF-α, MMP-9, dan SOD dalam Patogenesis Acne Vulgaris: Suatu Tinjauan Literatur Angelica Vanini Winata Taufiq; Pratiwi Pujilestari Sudarmono; Dian Widiyanti; Harliansyah
Didaktik : Jurnal Ilmiah PGSD STKIP Subang Vol. 12 No. 02 (2026): Volume 12 No. 02, Juni 2026 Produce
Publisher : STKIP Subang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36989/didaktik.v12i02.13412

Abstract

Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit involving follicular hyperkeratinization, excessive sebum production, Cutibacterium acnes colonization, inflammation, and oxidative stress. The activation of the nuclear factor kappa B (NF-κB) pathway and the inflammasome by C. acnes triggers the release of proinflammatory mediators, such as IL-1β, IL-6, and TNF-α, which contribute to the formation of comedones, papules, pustules, and severe inflammatory lesions. Furthermore, matrix metalloproteinase-9 (MMP-9) plays a role in extracellular matrix degradation, tissue damage, and scarring, while superoxide dismutase (SOD) reflects endogenous antioxidant capacity in response to increased reactive oxygen species (ROS). This review aims to examine the roles of IL-1β, IL-6, TNF-α, MMP-9, and SOD biomarkers in the pathogenesis of acne vulgaris. The method employed is a narrative review conducted through literature searches across PubMed, Scopus, and Google Scholar databases. The findings indicate that IL-1β, IL-6, and TNF-α serve as the primary mediators of acne inflammation. MMP-9 is associated with inflammatory severity, tissue destruction, and scar formation, whereas decreased SOD activity reflects elevated oxidative stress that exacerbates acne lesions. These findings confirm that IL-1β, IL-6, TNF-α, MMP-9, and SOD are critical biomarkers in the pathogenesis of acne vulgaris and possess the potential to be used as parameters for diagnosis, prognosis, and therapeutic evaluation of the condition.
Co-Authors Ainuzzahra Angelica Vanini Winata Taufiq Dian Widiyanti Luh Ade Lela Arika Nenden Lilis setiasih Pratiwi Pujilestari Sudarmono Puput Putuh Anisa