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All Journal Jurnal Medika: Medika Lumina: Indonesian Journal of Neurology
Tandry Meriyanti
Universitas Pelita Harapan
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Workshop Flebotomi: Peningkatan Keterampilan Pengambilan Darah Siswa Sekolah Dian Harapan Daan Mogot  Maroloan Aruan; Diana Intan Gabriella Lusiana; Tandry Meriyanti; Icha Paulina Simbolon; Maleakhi Samuel Mardiyono; Tiara Maasi; Ermi Maria Lukwaka
Jurnal Medika: Medika in progres
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/60zb7615

Abstract

Kegiatan Pengabdian kepada Masyarakat (PkM) ini dilatarbelakangi oleh kebutuhan siswa sekolah menengah untuk mengenal prosedur medis dasar sebelum memilih jurusan kuliah di bidang kesehatan. Kegiatan ini bertujuan memberikan pengetahuan dan keterampilan praktis teknik flebotomi (pengambilan darah vena dan kapiler) kepada siswa dan guru di SMA Sekolah Dian Harapan (SDH) Daan Mogot. Metode pelaksanaan kegiatan meliputi penyuluhan, demonstrasi, dan praktikum langsung (hands-on) menggunakan alat peraga manekin tangan flebotomi yang melibatkan 32 peserta. Evaluasi efektivitas pelatihan dilakukan melalui instrumen pre-test dan post-test. Hasil kegiatan menunjukkan peningkatan signifikan pada pemahaman peserta, dimana rata-rata nilai pengetahuan meningkat dari 65,97% pada pre-test menjadi 93,31% pada post-test. Analisis statistik menggunakan Paired Sample T-Test menunjukkan nilai signifikansi 0,003, dan perhitungan Normalized Gain Score (N-Gain) sebesar 0,71 yang masuk dalam kategori efektivitas tinggi. Peningkatan pemahaman tertinggi terlihat pada aspek teknis prosedural seperti sudut penusukan dan posisi bevel jarum. Disimpulkan bahwa workshop dengan metode simulasi manekin ini merupakan sarana yang efektif dan aman untuk menumbuhkan minat serta meningkatkan kompetensi dasar medis siswa tanpa risiko mencederai pasien nyata.
Diagnostic Accuracy of Blood-Based Biomarkers for Early Detection of Alzheimer’s Disease: A Systematic Review Cindy Permata Sari; Rocksy Fransiska V. Situmeang; Tandry Meriyanti
Lumina : Indonesian Journal of Neurology Vol. 2 No. 1 (2026): April: Lumina: Indonesian Journal of Neurology
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/lijn.v2i1.11078

Abstract

Introduction: Alzheimer’s disease (AD) continues to impose a significant global health burden, while early detection remains limited by the reliance on invasive and costly diagnostic methods such as PET imaging and cerebrospinal fluid (CSF) analysis. Blood-based biomarkers have gained attention as a more accessible alternative. This study aims to assess the diagnostic performance of plasma p-tau217, p-tau181, and Aβ42/40 in detecting early-stage AD. Methods: A systematic review was conducted using predefined inclusion criteria. Studies were selected if they evaluated plasma biomarkers against established reference standards (CSF biomarkers, PET imaging, or neuropathology), reported diagnostic accuracy measures, and included individuals with early cognitive impairment. Extracted data covered study characteristics, assay methods, population profiles, cutoff approaches, and longitudinal outcomes. Results: Seventeen studies involving more than 7,000 participants were included. Plasma p-tau217 consistently demonstrated the highest diagnostic accuracy across studies, with AUC values generally exceeding 0.90. Plasma p-tau181 also showed good diagnostic performance but with greater variability, particularly in early disease stages. In contrast, Aβ42/40 alone exhibited lower and less consistent accuracy, although its performance improved when combined with phosphorylated tau biomarkers. Variability in assay platforms, population characteristics, and cutoff values contributed to heterogeneity across studies. Conclusions: Plasma p-tau217 shows strong and consistent diagnostic performance across different populations and settings, approaching that of CSF and PET biomarkers. It holds considerable potential as a practical and minimally invasive tool for early AD detection, although further standardization is still needed. Keywords: Alzheimer’s Disease, P-tau217, Blood-based Biomarkers, Early Detection, Diagnostic Accuracy
Co-Authors Cindy Permata Sari Diana Intan Gabriella Lusiana Ermi Maria Lukwaka Icha Paulina Simbolon Maleakhi Samuel Mardiyono Maroloan Aruan Rocksy Fransiska V. Situmeang Tiara Maasi