Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Indri Dwi Rahasasti
Universitas An Nasher, Indonesia

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Optimization and Stability Testing of a Nanostructured Lipid Carrier (NLC)-Based Emulgel System for Transdermal Delivery of Anti-Inflammatory Drugs Muhammad Nurul Fadel; Emma Jayanti Besan; Dzukharian Munandar; Zola Efa Harnis; Indri Dwi Rahasasti
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.522

Abstract

Nanostructured Lipid Carriers (NLC) are second-generation lipid nanoparticles composed of solid and liquid lipids that improve drug loading, stability, and controlled release. Incorporating NLC into an emulgel enhances transdermal drug delivery by improving skin permeation and prolonging drug release. This study aimed to optimize an NLC-based emulgel using Design of Experiment (DoE) and evaluate its physicochemical properties, drug release, skin permeation, and stability. Diclofenac sodium was selected as the model drug. NLC was prepared using melt-emulsification ultrasonication and optimized with a three-factor Box–Behnken design before incorporation into Carbopol 940 gel. Characterization included particle size, zeta potential, entrapment efficiency, viscosity, spreadability, and drug release analysis. The optimized formulation showed a particle size of 187.4 ± 5.2 nm, zeta potential of −32.6 ± 1.8 mV, and entrapment efficiency of 91.3 ± 2.1%. Drug release reached 85.6% within 24 hours following the Korsmeyer-Peppas model. Skin permeation was significantly higher than conventional gel, and the formulation remained stable for six months at 25°C/60% RH.
Co-Authors Dzukharian Munandar Emma Jayanti Besan Muhammad Nurul Fadel Zola Efa Harnis