The increasing complexity of academic administration activities at Mutiara Mahakam Samarinda College of Health Sciences requires an integrated information system architecture capable of supporting effective and accurate management. The current academic services are still partially managed through manual, fragmented procedures, resulting in inefficiencies in data management, information exchange, and administrative processes. This study aims to design an enterprise architecture blueprint for the Academic Administration and Student Affairs unit using the TOGAF Architecture Development Method (ADM) framework. This paper employed a qualitative case study approach using observations, interviews, and document analysis with stakeholders in academic administration and student affairs management. The architectural planning process adopted several TOGAF ADM phases, including the preliminary, architecture vision, business architecture, information system architecture, and technology architecture phases. The business architecture analysis identified the primary academic service processes: new student admissions, academic operations, student graduation management, and alumni data administration. Information system architecture defined the required data entities and application modules to support integrated academic services. In contrast, the technology architecture proposed improvements in network infrastructure, server capacity, and cloud-based data management to enhance operational effectiveness and data accessibility. The results indicate that the proposed enterprise architecture blueprint can provide a structured framework for developing integrated academic information systems aligned with institutional business objectives. The proposed architecture also supports better coordination among organizational units, improves the efficiency of academic services, and enhances institutional readiness for future digital transformation initiatives. Implementation of the proposed enterprise architecture is expected to strengthen information management, improve service quality, and support strategic decision-making processes within the College of Health Sciences. Keywords: TOGAF, Architecture, Academics, Systems, Business, College of Health Sciences