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All Journal JOPS (Journal Of Pharmacy and Science)
Novia Risky Nur
Sekolah Tinggi Ilmu Farmasi Riau, Jl. Kamboja, Simpang Baru, Pekanbaru, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Jenis Minyak Terhadap Karakterisasi Sifat Fisik dan Disolusi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Asam Fenofibrat Wira Noviana Suhery; Meiriza Djohari; Novia Risky Nur
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4161

Abstract

The purpose of this study was to determine the effect of oil components of fenofibric acid self nanoemulsifying drug delivery systems. The investigated oils are long chain triglycerides (LCT) and medium chain triglycerides (MCT). The oils used are peanut oil (F1), castor oil (F2), virgin coconut oil (F3), and palm oil (F4). The study showed that the solubility of fenofibric acid in each oil F1 (0.57 ± 0.009 mg/ml), F2 (5.45 ± 0.17 mg/ml), F3 (0.85±0.007 mg/ml), F4 (1.04±0.03 mg/ml. The solubility of fenofibric acid in SNEDDS; F1 (27.72±0.54 mg/ml), F2 (35.50±0.96mg/ml), F3 (29.58±0.47 mg/ml), and F4 (32.14±0.44 mg/ml). The different spontaneous emulsification times were F1 (146.51 ± 2.85 seconds), F2 (37.11 ± 1.83 seconds), F3 (99.98 ± 0.63 seconds), and F4 (56.40 ± 1.71 seconds), and the results of dissolution at 60 minutes are F1 (73.66 ± 0.56%), F2 (96.52 ± 0.34%), F3 (77.87±0.81%), F4 (85.23 ± 0.98%). The type of oil can affect the characterization physical properties and dissolution of fenofibric acid SNEDDS. The best formula was shown by F2, which was a formula containing castor oil as an oil component.
Co-Authors Meiriza Djohari Wira Noviana, Wira Noviana