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Nola Rahmadasmi
Faculty of Pharmacy, University Fort De Kock, Bukittinggi, West Sumatra, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Efektivitas Fraksi Etil Asetat Eleutherine Bulbosa Terhadap Penurunan Kadar Kolesterol Total, Tekanan Darah Sistolik-Diastolik Pada Tikus Putih Jantan Haliza Diny Fauzia; Miming Andika; Putri Nilam Sari; Rizqa Hasanah; Fajrian Aulia Putra; Oryza Sativa Fitriani; Nola Rahmadasmi
JURNAL FARMASI DAN MAKANAN Vol 7 No 2 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i2.4707

Abstract

Eleutherine Bulbosa is one of the plants cultivated by the community for traditional medicine. It's like lowering hypercholesterolemia. Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. Besides, it can also lower hypertension. Hypertension is a condition in which blood pressure exceeds the normal limit, with systolic pressure above 140 mmHg and diastolic blood pressure above 90 mmHg. The study aims to look at the effectiveness of the Eleutherine Bulbosa ethyl acetate fraction against the reduction in total cholesterol levels, systolic blood pressure, and diastolic blood pressure in male white rats. Animal cholesterol levels were raised using MLT for 22 days. Cholesterol parameters were tested using a Dumolab DC20 photometer. The inducer used to raise blood pressure is 8% NaCl for 14 days. Blood pressure is measured using non-invasive blood pressure. (NIBP). The results of the research showed that the flavonoid groups that play a role in lowering high cholesterol levels are the anthocyanins and quercetin, while the alkaloid compounds play a part in lowering high blood pressure. Data analysis showed significant results (p<0.05). It can be concluded that the administration of the ethyl acetate fraction Eleutherine Bulbosa is capable of lowering high cholesterol levels and high systolic-diastolic blood pressure.
Uji Efektivitas Fraksi Etil Asetat Rambut Jagung (Zea mays L) Sebagai Antihipertensi Pada Tikus Putih Jantan Miming Andika; Asra Laila; Rizqa Hasanah; Fajrian Aulia Putra; Oryza i Sativa Fitrian; Nola Rahmadasmi
JURNAL FARMASI DAN MAKANAN Vol 8 No 1 (2024): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

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Abstract

Corn hair is a group of stigmas that are smooth, soft, and look like threads or yellowish hair. The use of corn hair, which is a waste from corn cultivation, is still limited to its use as a traditional medicine. Hypertension or high blood pressure is a chronic condition characterized by increased blood pressure on the walls of arteries. This study aims to determine the effect of the effectiveness of the ethyl acetate fraction of corn hair (Zea mays L) on the reduction of blood pressure in male white rats of the Wistar strain. This type of study is an experimental pre-test and post-test control group design, using Wistar male white rat test animals, the inducing used is NaCl 8%. Blood pressure measurements are carried out using the CODA®. Data analysis using the One Way Anova Statistical test followed by the Duncan test obtained the result that the administration of the ethyl acetate fraction of corn hair with doses of 250 mg/kgBB, 500 mg/kgBB, and 1000 mg/kgBB had a significant effect on reducing blood pressure (p<0.05). It can be concluded that the variation in the dose of the ethyl acetate fraction of corn hair (Zea mays L) has a significant difference in the reduction of blood pressure and affects histological improvement. The effective dose of the ethyl acetate fraction of corn hair in lowering blood pressure is a dose of 1000 mg/kgBB.
Co-Authors Asra Laila Fajrian Aulia Putra Haliza Diny Fauzia Miming Andika Miming Andika Oryza i Sativa Fitrian Oryza Sativa Fitriani Putri Nilam Sari Rizqa Hasanah Rizqa Hasanah