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All Journal JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis)
Rahma Dona
STIFAR Riau
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Sintesis dan Karakterisasi Senyawa 4'-Aminokalkon dengan Metode Pengadukan dan Refluks Termodifikasi Rahma Dona; Enda Mora; Nurul Huda
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.6559

Abstract

Chalcone is a secondary metabolite belonging to the minor group of flavonoids which has various biological activities. Several chalcone derivatives with amino groups attached to their rings have anti-inflammatory, antibacterial, antitumor and antimalarial activities. However, because the amount is limited, the percentage in plants is small, and the structural variations are relatively small, it needs to be synthesized in the laboratory. This study aims to compare the results of the synthesis of 4'-aminochalcone compounds using the stirrer method at room temperature and modified reflux at an increased temperature. Synthesis using the stirrer method was carried out for 4 hours at room temperature with NaOH 40% as catalyst, while synthesis using the modified reflux method was carried out using a monowave-50 for 11 minutes at a temperature of 80oC with the same catalyst. The molecular structures of the synthesized compound were confirmed by UV spectroscopy, FT-IR, and 1H-NMR spectral data. Based on this study results, it was found that the synthesis of 4'-aminochalcone compounds using the stirrer method had better results compared to the modified reflux method. The 4'-aminochalcone compound using the stirrer method had a pure compound yield of 47.36%, while the 4'-aminochalcone compound using the modified reflux method had an impure yield of 2.57%. Characterization using UV spectroscopy, FT-IR, and 1H-NMR shows that the synthesis results match the structure of the target molecule.
Synthesis and In Vitro Antimalarial Activity of Amino Chalcone Derivatives Compounds Through Inhibition of Heme Polymerization Rahma Dona; Jasril; Rudi Hendra; Neni Frimayanti
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.127-135.2024

Abstract

This study aims to investigate the potential of chalcone derivatives as antimalarial agents. The structure of the  chalcone derivatives was designed by inserting amino substituents on acetophenone and methoxy variants on benzaldehyde to  produce three amino chalcone derivatives (C1, C2, and C3). The synthesis was carried out by carrying out the Claisen-Schmidt  condensation reaction with NaOH 40% as catalyst, resulting in compound yields ranging from 66% - 83%. The structure of the  three compounds was determined by FTIR, MS, and 1H-NMR spectroscopy techniques, which confirmed that the compounds  had structures that were in line with the desired molecular structure. The antimalarial activity test was carried out by inhibiting  the heme polymerization process into hemozoin (β-hematin) using hydroxychloroquine sulfate as a positive control. Absorption  measurements were carried out at two different wavelengths, namely 415 nm and 630 nm. The results of the IC50 antimalarial  activity of the three compounds (C1, C2, C3) were obtained respectively at 227.61; 115.18; 260.01 µg/mL and positive control of  184.98 µg/mL. From these results, it was found that compound C2 showed better antimalarial activity compared to the other two  compounds and positive control.
Co-Authors Enda Mora Jasril Neni Frimayanti Nurul Huda Rudi Hendra