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All Journal Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran JIKA
Helga Pasadena
Universitas Abdurrab
Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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DERMATITIS ATOPI FASE INFATIL: SEBUAH LAPORAN KASUS Helga Pasadena; Andre Hastra
Jurnal Ilmu Kesehatan Abdurrab Vol. 1 No. 4 (2023): Vol 1 No 4 Desember 2023
Publisher : LPPM Universitas Abdurrab

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Abstract

Atopic dermatitis (DA) is skin inflammation in the form of recurrent inflammation, accompanied by itching, and affecting certain parts of the body, especially the face in babies (infantile phase) and the flexural parts of the extremities (in childhood phase). Atopic dermatitis often occurs in babies and children, and around 50% disappear by adolescence, sometimes it can persist, or even only start to appear in adulthood. The disorder can occur at any age, and is one of the most common diseases in infants and children, as many as 45% occur in the first 6 months of life. Atopy is a genetically determined condition manifested by a familial predisposition to allergic disorders such as asthma, hay fever, and urticaria. The case of a 6-month-old baby boy has been reported with symptoms of reddish spots accompanied by itching on the left cheek, both groins, and on the left hand. The patient has been given appropriate treatment.
Efektivitas Curcumin Dalam Mengurangi Peradangan Pada Dermatitis Atopik Helga Pasadena; Santi Widiasari
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 3 No. 2 (2025): Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v3i2.4881

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by pruritus, erythema, and impaired skin barrier function. Conventional treatments such as topical corticosteroids and calcineurin inhibitors effectively reduce inflammation but pose potential adverse effects that limit their long-term use. Consequently, natural-based alternatives like curcumin have gained increasing interest. Curcumin, a principal polyphenol in turmeric (Curcuma longa), is known for its anti-inflammatory, antioxidant, and immunomodulatory properties. Its mechanisms in AD involve the inhibition of the NF-κB signaling pathway, downregulation of proinflammatory cytokines (IL-4, IL-13, TNF-α), and enhancement of filaggrin and ceramide production, which are crucial for restoring skin barrier function. This study is a systematic review aimed at evaluating the efficacy of curcumin in alleviating AD-related inflammation based on recent clinical and experimental studies. The meta-analysis revealed that nano-curcumin formulations were more effective than conventional curcumin in reducing atopic skin lesions and transepidermal water loss (TEWL). Additionally, combining curcumin with emollients or essential oils exhibited synergistic effects in improving skin hydration and reducing inflammation. In conclusion, curcumin demonstrates significant potential as an adjuvant therapy for AD; however, further research is required to determine its long-term efficacy and safety profile in clinical applications.
Co-Authors Andre Hastra Santi Widiasari