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Wahyu Margi Sidoretno
Fakultas Farmasi dan Ilmu Kesehatan Universitas Abdurrab
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Gambaran Efek Samping Obat Kemoterapi Pada Pasien Kanker Payudara Di RSUD Arifin Achmad Pekanbaru Suci Rahma Ningsih; Wahyu Margi Sidoretno
Jurnal Ilmu Kesehatan Abdurrab Vol. 2 No. 1 (2024): Volume 2 Nomor 1 Maret 2024
Publisher : LPPM Universitas Abdurrab

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The most prevalent cancer in women, though it can strike men as well, is breast cancer. Breast cancer is brought on by unchecked cell proliferation, which, if uncontrolled, can turn into a malignant tumour. One breast cancer treatment that requires monitoring and careful attention to adverse effects is chemotherapy. Determining the adverse effects of chemotherapy on patients with breast cancer was the goal of this study. This study uses an observational, non-experimental research design that is descriptive and evaluative in nature. Data has been collected from the medical records of 16 patients with 11 chemotherapy medication regimens who satisfied the inclusion criteria and had an initial diagnosis of breast cancer in the July 2023. The seven types of chemotherapy medications that are employed are: paclitaxel, cisplatin, doxorubicin, docetaxel, carboplatin, cyclophosphamide, herzemab, and fonkopec. Docetaxel with carboplatin was the most often prescribed chemotherapeutic medication combination, accounting for 4 individuals (25%). Potential side effects that arise during treatment are mucositis, decreased appetite, nausea and vomiting, alopecia, changes in skin and nail color, myalgia, fatigue, dizziness, weakness and numbness in the legs. The side effects that consistently manifested in all patients (100%) were myalgia, alopecia, and nausea and vomiting, according to the results.
Chitosan-Honey Biomembrane Contributes to the Healing Process of Burn Wound in Male White Rats Muslim Suardi; Wahyu Margi Sidoretno; Refika Sukriyani
Jurnal Ilmu Kesehatan Abdurrab Vol. 2 No. 3 (2024): Volume 2 Nomor 3 September 2024
Publisher : LPPM Universitas Abdurrab

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Chitosan and honey posses antibacterial activity. The research objectives were to prepare chitosan and chitosan honey biomembrane, and evaluate the influence of chitosan and chitosan-honey-PVA biomembrane on burn wound healing in male white rats. The skin irritation was tested on five healthy volunteers. Twenty-four rats were divided into four groups. Burns were induced on the dorsal skin using a 2-cm-diameter metal plate at 80-100 oC for 5 seconds. The burn area was measured on days 3, 5, and 7 after injury. New blood vessels and bullae were observed histopathologically in scar tissue. Irritation was tested on five healthy volunteers. Bullae were observed in 5, 5, 5, 1, and 3 rats in the negative control, chitosan biomembrane, chitosan-honey biomembrane, and positive control (Sterile Amnion Lyophilized) groups, respectively. The wound area on day 5 after treatment was 3.06 ± 0.088, 2.29 ± 0.176, 2.64 ± 0.147, and 2.43 ± 0.201 cm2 for the negative control, positive control, chitosan-PVA biomembrane, and chitosan-honey-PVA biomembrane groups, respectively. No significant difference was found between the positive control and chitosan-honey-PVA biomembrane (p > 0.05). Chitosan-honey-PVA biomembrane contributes to the healing process of burn wounds.
Co-Authors Muslim Suardi Refika Sukriyani Suci Rahma Ningsih