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Muslim Suardi
Fakultas Farmasi dan Ilmu Kesehatan Universitas Abdurrab
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Gelatin Hasil Transformasi Kulit Ikan Patin (Pangasius hypohthalmus) sebagai Gelling Agent dalam Formulasi Gel Piroksikam Muslim Suardi
Jurnal Ilmu Kesehatan Abdurrab Vol. 2 No. 1 (2024): Volume 2 Nomor 1 Maret 2024
Publisher : LPPM Universitas Abdurrab

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Piroxicam is an effective non-steroidal anti-inflammatory drug, but it has serious side effects orally. The research was conducted to formulate piroxicam in gel dosage form using gelatin transformed from catfish skin (Pangasius hypophthalmus) as a gelling agent. Using this ingredient transformed from pig and cow is unacceptable for certain religious adherents. This study aims were to formulate piroxicam gel and determine the release of piroxicam from gel at various concentrations of 0.75, 0.875, and 1%, while innovator product (F4) was used as a positive control. The evaluations performed were organoleptic, homogeneity, pH, spreadability, and release profile. The release of piroxicam from the gel produced was conducted using a modified paddle-type dissolution device equipped with an eggshell membrane placed on a metal disk. The level of piroxicam dissolved was measured using a UV spectrophotometer at λmax of 356.4 nm. The release kinetics of piroxicam gel formulas F1, F2, F3 and F4 followed zero-order kinetics model. The dissolution efficiency and T90 from formulas F1, F2, F3, and F4 value were highly significant differences (p < 0.01), while the dissolution rate were significant differences (p < 0.05). All of formula fulfill the requirements except spreadability characteristic.
Chitosan-Honey Biomembrane Contributes to the Healing Process of Burn Wound in Male White Rats Muslim Suardi; Wahyu Margi Sidoretno; Refika Sukriyani
Jurnal Ilmu Kesehatan Abdurrab Vol. 2 No. 3 (2024): Volume 2 Nomor 3 September 2024
Publisher : LPPM Universitas Abdurrab

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Chitosan and honey posses antibacterial activity. The research objectives were to prepare chitosan and chitosan honey biomembrane, and evaluate the influence of chitosan and chitosan-honey-PVA biomembrane on burn wound healing in male white rats. The skin irritation was tested on five healthy volunteers. Twenty-four rats were divided into four groups. Burns were induced on the dorsal skin using a 2-cm-diameter metal plate at 80-100 oC for 5 seconds. The burn area was measured on days 3, 5, and 7 after injury. New blood vessels and bullae were observed histopathologically in scar tissue. Irritation was tested on five healthy volunteers. Bullae were observed in 5, 5, 5, 1, and 3 rats in the negative control, chitosan biomembrane, chitosan-honey biomembrane, and positive control (Sterile Amnion Lyophilized) groups, respectively. The wound area on day 5 after treatment was 3.06 ± 0.088, 2.29 ± 0.176, 2.64 ± 0.147, and 2.43 ± 0.201 cm2 for the negative control, positive control, chitosan-PVA biomembrane, and chitosan-honey-PVA biomembrane groups, respectively. No significant difference was found between the positive control and chitosan-honey-PVA biomembrane (p > 0.05). Chitosan-honey-PVA biomembrane contributes to the healing process of burn wounds.
Co-Authors Refika Sukriyani Wahyu Margi Sidoretno