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All Journal Indonesian Journal of Pharmaceutical Science and Technology
Dwiantika, Ajeng Sunthi
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Computer Science & IT Medicine & Pharmacology

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Ethanol Extract of Nigella sativa Attenuates Eosinophilic Inflammation and Epithelial Remodeling in an Ovalbumin-Induced Rat Model Dewi, Rika Sari; Sandhiutami, Ni Made Dwi; Desmiaty, Yesi; Dwiantika, Ajeng Sunthi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.67195

Abstract

Allergic airway inflammation is commonly associated with eosinophilic infiltration and epithelial remodeling, which impair respiratory function and contribute to tissue damage. This study investigated the therapeutic potential of the ethanol extract of Nigella sativa in an ovalbumin-induced rat model of allergenic airway response. Ethanol extracts were tested in an ovalbumin-induced rat model using Sprague-Dawley rats (n=36), comparing normal, negative controls, 0.009 mg/g BW salbutamol (positive control), and three inhaled extract doses (12.25, 24.50, 49 g/kg BW). Comprehensive analysis included physiological parameters (oxygen saturation), inflammatory biomarkers (lung eosinophil count), and pulmonary histopathology (epithelial thickness). The highest dose (49 g/kg) matched salbutamol in improving oxygen saturation (86.75% vs. 88%, p=0.9917) and reducing epithelial thickness (81.50 µm vs. 81.75 µm, p=0.9999), while suppressing eosinophil infiltration (0.73 vs. 1.45 cells/field, p=0.3348). These results confirm Nigella sativa’s efficacy in attenuating airway inflammation via eosinophil-targeted mechanisms without structural epithelial alterations. The study validates traditional applications of Nigella sativa and proposes an evidence-based framework for integrating phytotherapy into respiratory medicine.
Co-Authors Ni Made Dwi Sandhiutami Rika Sari Dewi Yesi Desmiaty, Yesi