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Mardhatillah Mardhatillah
1Program Studi D-III Farmasi, Sekolah Tinggi Ilmu Kesehatan Darul Azhar Batulicin, Tanah Bumbu, Kalimantan Selatan
Health Professions Nursing Public Health

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UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK KOMBINASI DAUN KASTURI (Mangifera casturi) DAN DAUN KELAPA SAWIT (Elaeis guineensis) TERHADAP BAKTERI Propionibacterium acnes: ANTIBACTERIAL ACTIVITY TEST OF COMBINATION EXTRACT OF MUSHROOMS (Mangifera casturi) AND OIL PALM (Elaeis guineensis) LEAVES AGAINST Propionibacterium acnes Mardhatillah Mardhatillah; Nur Mahdi; Anita Ratna Dilla
Journal of Pharmacology Experiment and Pharmaceutical Technology Vol. 2 No. 1 (2026): JPEPT
Publisher : DSM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64015/jpept.v2i1.7

Abstract

Acne is a common skin disorder worldwide, with a prevalence of 9.4%, mainly affecting adolescents. A key factor is Propionibacterium acnes, which has developed resistance to several antibiotics. This highlights the need for safe, natural alternatives. Kasturi mango leaves (Mangifera casturi) and oil palm leaves (Elaeis guineensis) leaves contain flavonoids and saponins with antibacterial potential. This study aimed to evaluate the antibacterial activity of their combined extracts against P. acnes. The research used an experimental design with the disc diffusion method. Seven groups were tested: single extract of kasturi mango leaves, single extract of oil palm leaves, combinations I (1:2), II (2:4), III (4:4), positive control (erythromycin), and negative control (sterile distilled water). Data were analyzed using SPSS to assess statistical differences. Results showed weak antibacterial activity from the combined extracts. The highest effect, combination III (4:4; 80 mg EDK : 80 mg EDKS), produced a 4.5 mm inhibition zone, still lower than the positive control. This suggests the tested concentrations were insufficient to suppress P. acnes. The Kruskal–Wallis test produced a p-value of 0.014 (p < 0.05), confirming significant differences among groups. Further studies should test higher single-extract concentrations before combining, to optimize antibacterial effects against P. acnes.
Co-Authors Anita Ratna Dilla Nur Mahdi