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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Majalah Biomorfologi (Biomorphology Journal)
Kabir Ardiansyah tangkari
Bachelor of Medicine Program, Faculty of Medicine, Universitas Muhammadiyah Metro, Lampung
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Protective Role of Urtica dioica Extract on MDA Levels, Epididymal p53 mRNA, and Sperm Profile in Obese Sprague–Dawley Rats Harni Sutiani; Kabir Ardiansyah tangkari; Jurnalis Gempaning Tyas; Zaenudin; Dicky Mohammad Rizal; Jajar Setiawan
Majalah Biomorfologi Vol. 36 No. 1 (2026): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v36i1.2026.75-83

Abstract

Background: Obesity, resulting from an imbalance between energy intake and expenditure, leads to excessive fat accumulation and is associated with metabolic disorders and male infertility. Increased oxidative stress in obesity contributes to impaired spermatogenesis, altered sperm quality, and disruption of reproductive function. Urtica dioica contains bioactive compounds with antioxidant, anti-inflammatory, and anti-apoptotic properties. Objective: To evaluate the effect of Urtica dioica extract on malondialdehyde (MDA) levels, epididymal p53 mRNA expression, and sperm quality in obese male rats. Materials and Methods: The authors conducted an experimental study in 25 male Sprague–Dawley rats, divided into five groups (n = 5): non-obese control, obese control, and three treatment groups (125, 250, and 500 mg/kg BW). Obesity was induced using a high-fat and fructose diet for 6 weeks, followed by 4 weeks of treatment. We measured MDA levels using the TBARs, p53 mRNA expression by PCR, and sperm parameters according to WHO standards. Data were analyzed using ANOVA or Kruskal–Wallis tests (p < 0.05). Results: Obese groups demonstrated higher body weight and Lee index of > 300 (p < 0.001). The administration of Urtica dioica extract at 500 mg/kg BW resulted in a significant decrease in MDA levels and an increase in p53 mRNA expression compared to the obese control (p < 0.05), which demonstrated higher sperm concentration, motility, and viability, along with lower morphological abnormalities than those in obese controls (p < 0.05). Conclusion: Urtica dioica extract at 500 mg/kg BW exhibits protective effects against oxidative stress and improves reproductive parameters in obese male rats.
Anti-Hyperglycemic Activity of Urtica dioica Extract in Obese Male Sprague Dawley Rats: Evaluation of HOMA-IR and HOMA-β Zaenudin Zaenudin; Jurnalis Gempaning Tyas; Kabir Ardiansyah Tangkari; Harni Sutiani; Arta Farmawati; Prasetyastuti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 01 (2026): Qanun Medika Vol 10 No 01 January 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i01.28178

Abstract

Obesity is characterized by adipocyte accumulation that impairs glucose uptake, leading to insulin resistance, hyperglycemia, and an increased risk of diabetes mellitus. Given the limitations and adverse effects of pharmacological therapies for diabetes, alternative agents are needed. Urtica dioica contains flavonoids with anti-inflammatory and antioxidant properties that may improve glucose homeostasis. This experimental study employed a pre-test and post-test control group design using 25 male Sprague Dawley rats divided into five groups: healthy control (K1), obese control (K2), and three obese groups receiving Urtica dioica extract at doses of 125, 250, and 500 mg/kgBW (D1–D3) for four weeks. Data were analyzed using one-way ANOVA and paired t-test. Administration of Urtica dioica extract at 500 mg/kgBW (D3) significantly reduced blood glucose (79.90 ± 2.51 vs. 177.92 ± 3.30; p<0.05), increased insulin levels (16.20 ± 0.29 vs. 12.82 ± 0.28; p<0.05), decreased HOMA-IR (3.19 ± 0.07 vs. 5.63 ± 0.14; p<0.05), and enhanced HOMA-β (351.20 ± 58.77 vs. 40.21 ± 1.63; p<0.05) compared with untreated obese controls. In conclusion, four-week administration of Urtica dioica extract effectively improved insulin resistance and β-cell function in obese rats, with the most pronounced effect observed at a dose of 500 mg/kgBW.
Co-Authors Arta Farmawati Dicky Mohammad Rizal Harni Sutiani Harni Sutiani Jajar Setiawan Jurnalis Gempaning Tyas Prasetyastuti Zaenudin Zaenudin Zaenudin