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FERINA AYU MAHARANI HAIBAR
Universitas Jenderal Soedirman
Dentistry

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Antibiofilm Activity of Secang Wood (Caesalpinia sappan) Ethanol Extract Against Cariogenic Streptococcus sanguinis FERINA AYU MAHARANI HAIBAR; Christiana Cahyani Prihastuti; Meylida Ichsyani
Journal of Indonesian Dental Association Vol. 8 No. 1 (2025): May
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v8i1.1278

Abstract

Streptococcus sanguinis merupakan bakteri pioneer colonizers yang berperan dalam perkembangan biofilm penyebab penyakit karies gigi. Ekstrak etanol kayu secang memiliki potensi antibiofilm yang dapat dikembangkan sebagai terapi alternatif obat kumur untuk pencegahan karies gigi. Penelitian bertujuan untuk mengetahui aktivitas antibiofilm ekstrak etanol kayu secang (Caesalpinia sappan L.) terhadap Streptococcus sanguinis penyebab karies gigi. Aktivitas antibiofilm menggunakan dua uji, uji pertama degradasi biofilm dan uji kedua penghambatan biofilm lanjutan dengan MtP Assay dan pewarnaan kristal violet 1% yang densitas optiknya dibaca pada panjang gelombang 620 nm. Data hasil degradasi penelitian dianalisis menggunakan One-Way ANOVA dan post-hoc LSD. Hasil menunjukkan terdapat perbedaan bermakna seluruh konsentrasi ekstrak dengan kontrol negatif. Konsentrasi efektif degradasi biofilm yaitu konsentrasi 1,56 mg/mL dan konsentrasi efektifpenghambatan pertumbuhan biofilm pada konsentrasi 0,39 mg/mL. Simpulan dari penelitian ini adalah terdapat aktivitas antibiofilm ekstrak etanol kayu secang terhadap Streptococcus sanguinis penyebab karies gigi.
A Uremic Stomatitis in Patient with Chronic Kidney Disease on Hemodialysis at RSUD Prof. Dr. Margono Soekarjo Evi Triviana Sufyaning Rahayu; FERINA AYU MAHARANI HAIBAR; Twasi Anilamaba; Rinawati Satrio; Wahyu Djatmiko
Journal of Indonesian Dental Association Vol. 9 No. 1 (2026): April
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v9i1.1486

Abstract

Introduction: Chronic Kidney Disease (CKD) is a condition of slow and irreversible decline in kidney function, leading to the accumulation of metabolic waste products such as urea and creatinine. The buildup of these toxins can trigger systemic manifestations, including oral lesions such as uremic stomatitis. Although often overlooked, these oral manifestations can reduce patients’ quality of life and nutritional status due to pain during eating. Case Report: A 63-year-old female patient diagnosed with Chronic Kidney Disease (CKD) was admitted to Prof. Dr. Margono Soekarjo Regional General Hospital. Laboratory tests revealed elevated levels of urea, creatinine, and potassium, as well as decreased hemoglobin and hematocrit, indicating the presence of anemia and hyperkalemia. An intraoral examination revealed an ulcerative lesion on the right lateral aspect of the tongue with a grayish-white base and a purplish hemorrhagic lesion on the base of the tongue, accompanied by pain during eating. The diagnosis was established as uremic stomatitis based on subjective and objective examinations, as well as a complete blood count. Management included systemic therapy and oral care using 0.2% chlorhexidine gluconate and Candistatin drops. Conclusion: Chronic kidney disease can trigger the appearance of uremic stomatitis in the oral cavity. Therefore, clinical examination of the oral cavity is essential for the early identification of systemic disorders while supportive management and oral hygiene education can help prevent complications and improve the comfort and quality of life of CKD patients.
Co-Authors Christiana Cahyani Prihastuti Evi Triviana Sufyaning Rahayu Meylida Ichsyani Rinawati Satrio Twasi Anilamaba Wahyu Djatmiko