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All Journal Indonesian Journal of Global Health research Indonesian Journal of Global Health Research
Awalia Astarina
Universitas Sumatera Utara
Education Health Professions Languange, Linguistic, Communication & Media Nursing Public Health

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Clinical Features and Histopathologic Examination in Supporting The Diagnosis of Exfoliative Dermatitis Suspected Caused by Captopril in Child : A case report Awalia Astarina; T Ibnu Alferraly; Deryne Anggia Paramita; Kristo A Nababan
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6870

Abstract

Exfoliative dermatitis (ED) is defined as diffuse erythema and scaling of the skin involving more than 90% of the total body skin surface area. It is a reaction pattern and cutaneous manifestation of a myriad of underlying ailments, including psoriasis and eczema, or a reaction to the consumption of certain drugs. Though some experts believe it does not pose a significant risk of death, erythroderma is a potentially life-threatening condition that requires proper diagnosis, identification of underlying etiology, and management. Several factors have been implicated as triggers for erythroderma and can be grouped into several general categories, including preexisting dermatoses, drugs, and malignancies. Drugs Involved in ED, one of the drugs that cause it is cardiac drugs such as captopril. Captopril, an angiotensin-converting enzyme (ACE) inhibitors containing a sulfhydryl group and has occasionally been implicated in complex immunological diseases, this chemical group has been considered the culprit of allergic reactions to captopril. Histopathologic examination is important to exclude differential diagnosis. Management of ED involves combining symptomatic relief with addressing the underlying etiology and potential systemic complications. In patient hospitalization is required in acute cases.
Update on Adult Dermatomyositis Cut Putri Hazlianda; Awalia Astarina
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1387

Abstract

Dermatomyositis is a systemic autoimmune disorder that is an inflammatory disease of the skin, muscles, and blood vessels with characteristic skin eruptions accompanied by proximal limb muscle weakness or atrophy. This condition can affect children and adults. The pathognomonic lesions are the heliotrope sign, Gottron's papule, and Gottron's sign Malignancy can occur in 10%- 20%, with nasopharyngeal cancer being the most common. Etiology and pathogenesis are autoimmune; other triggers include drugs, infection, sun exposure, and malignancy. The latest diagnosis criteria by EULAR/ACR 2017 and Sontheimer et al. can be used as a reference for diagnosis. Comprehensive management of dermatomyositis aims to decrease symptoms, increase quality of life, and early detection of malignancy. Topical therapy options for dermatomyositis are topical calcineurin inhibitors and corticosteroids. In addition, systemic therapy consists of steroid- sparing agents, antimalarials, and corticosteroids. The current treatment of dermatomyositis is the administration of intravenous Immunoglobulin (IVIG) and rituximab.
Co-Authors Cut Putri Hazlianda Deryne Anggia Paramita Kristo A Nababan T Ibnu Alferraly