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Azuxetullatif Azuxetullatif
Department of Pharmacy, Universitas Sumatera Barat, Padang Pariaman 25581, Indonesia
Computer Science & IT Electrical & Electronics Engineering Engineering Materials Science & Nanotechnology

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Antibacterial activity of a fraction of Senna alata L. leaves against Staphylococcus aureus: A comparative study of solvent types and concentrations Eldya Mossfika; Dwi Saputra; M Saka Abeiasa; Azuxetullatif Azuxetullatif
Science, Technology, and Communication Journal Vol. 6 No. 3 (2026): SINTECHCOM Journal (June 2026)
Publisher : Lembaga Studi Pendidikan dan Rekayasa Alam Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59190/stc.v6i3.379

Abstract

Skin infections occur when microorganisms enter the bloodstream, spread to other organs, multiply, and cause severe illness. One of the common causative agents is Staphylococcus aureus. Thank to their phytochemical content, the Senna alata L. leaf have been used traditionally for antibacterial properties. Herein, we report the utilize of Senna alata L. leaf extract as an antibacterial agent against the Staphylococcus aureus grow up using a two-solvent fractionation method i.e. water and 96% alcohol at concentrations of 40%, 50%, 60%, and 70%. The phytochemical screening and disc diffusion tests were adopted to determine the phytochemical compounds and antibacterial efficacy of the fraction, respectively. Further, the statistical analysis including normality and homogeneity tests followed by a two-way ANOVA to evaluate the effects of solvent and concentration. The phytochemical screening detected the presence of alkaloids, flavonoids, tannins, and saponins in both fractions. The antibacterial efficacy results shows that the water and alcohol fractinations at a concentration of 70% produced the greatest antibacterial effect, with an inhibition zone diameter of 18 ± 0.18 mm and 18.90 ± 0.32 mm, respectively. A two-way ANOVA revealed a significant interaction (p = 0) between solvent type and concentration, indicating that antibacterial potency depends on both factors. These results confirm that the Senna alata L. leaf extract has a good potential for use as an antimicrobial agent.
Formulation and effectiveness testing of mouthwash (Gargarisma) combination of guava leaves (Psidium guajava L. folium) and bay leaves (Syzygium polyanthum folium) extracts as an antibacterial agent against Streptococcus mutans Anggun Rizca Gustiny; Azuxetullatif Azuxetullatif; Reren Oktivana; M Saka Abeiasa; Eldya Mossfika
Science, Technology, and Communication Journal Vol. 7 No. 1 (2026): SINTECHCOM Journal (October 2026)
Publisher : Lembaga Studi Pendidikan dan Rekayasa Alam Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59190/stc.v7i1.422

Abstract

The dental caries disease is the result of the bacterial infection by Streptococcus mutans bacteria which cause the decay of the teeth. The extraction of guava leaves (Psidium guajava L. folium) and bay leaves (Syzygium polyanthum (Wight) Walp.) has secondary metabolites with antibacterial action. This research is intended to investigate the effect of combination of both plant extracts as the inhibitors of Streptococcus mutans by making the mouthwash in the three concentrations of F1, F2, and F3. Plant identification, phytochemical testing, physical testing, and disc diffusion test are done in order to identify the identity of the plants, metabolite content of plant, physical quality of the formulation, and antibacterial activity of the formulation. Statistical analysis used for the inhibition zone diameter (IZD) value is one-way ANOVA. From the phytochemical test result, both of plant extracts have secondary metabolites of alkaloid, flavonoid, tannin, and phenol. Physical quality of the F1, F2, and F3 formulations remained stable until the four weeks of storage period. Antibacterial assays revealed that F3 exhibited the highest inhibitory activity against Streptococcus mutans with an IZD of 8.67 ± 0.764 mm, followed by F2 at 7.67 ± 0.577 mm and F1 at 4.33 ± 3.786 mm. One-way ANOVA demonstrated significant differences in IZD between groups (F = 17.135; p < 0.001), following the order of F3 > F2 > F1. Post hoc analysis using the Games-Howell test showed that F2 and F3 had significantly higher antibacterial activity than the negative control. However, the differences in effectiveness among F1, F2, and F3 were not statistically significant.
Co-Authors Anggun Rizca Gustiny Dwi Saputra Eldya Mossfika M Saka Abeiasa Reren Oktivana