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All Journal Jurnal Ventilator: Jurnal Riset Ilmu Kesehatan dan Keperawatan CERATA
Nadira Khaerunnisa
Universitas Mataram
Health Professions Medicine & Pharmacology Nursing Public Health

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Literatur Review: Analisis Penetapan Kadar Ibuprofen Dan Validasi Metode Menggunakan Berbagai Sistem High-Performance Liquid Chromatography (HPLC) Iglima Cikita; Vania Aisyah Aulia Syahda Haris; Zaskia Rizky Maulana; Nadira Khaerunnisa; Raditya Wedhagama; Lina Permatasari
CERATA Jurnal Ilmu Farmasi Vol 16 No 2 (2025): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v16i2.1448

Abstract

Ibuprofen adalah obat golongan Non Steroid Anti-Inflamatory Drug (NSAID) yang digunakan untuk analgetik dan antipiretik. Tingginya penggunaan obat ini memerlukan metode analisis yang akurat untuk menetapkan kualitas dan kadarnya. High-Performance Liquid Chromatography (HPLC) menjadi instrumen pilihan dalam analisis farmasi. Penelitian ini bertujuan mengevaluasi validitas metode HPLC fase normal dan fase terbalik dalam penetapan kadar ibuprofen. Metode yang digunakan adalah Systematic Literature Review (SLR) dengan Parameter validasi yang dianalisis meliputi linearitas, akurasi, presisi, Limit of Detection (LOD), dan Limit of Quantification (LOQ). Hasil menunjukkan bahwa kedua fase HPLC memiliki kinerja yang baik dalam menganalisis ibuprofen, dengan fase terbalik menunjukkan keunggulan. Penelitian ini memberikan kontribusi dalam memilih metode HPLC yang sesuai untuk analisis ibuprofen secara akurat.
Review Artikel: Drug Related Problems pada Penyakit Kronis: Implikasi Klinis dan Upaya Intervensi Nadira Khaerunnisa; Wulan Desi Rahmayanti; Anisa Zanuba; Zilfia Rahayu; Ditha Zanetti Octavia; Tuhfatul Ulya
Jurnal Ventilator Vol. 4 No. 3 (2026): September : Jurnal Ventilator
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/ventilator.v4i3.2720

Abstract

Chronic diseases such as type 2 diabetes mellitus, hypertension, asthma, and chronic kidney disease require long-term therapy that often involves multiple medications, increasing the risk of Drug Related Problems (DRPs). This review article summarizes patterns of DRPs and the contributing factors based on recent studies. The findings indicate that common DRPs include inappropriate dosing, drug interactions, drug use without indication, untreated indications, and ineffective therapy. In chronic kidney disease, DRPs frequently arise from inadequate dose adjustment in response to declining renal function, while in asthma, suboptimal medication use and incorrect inhaler technique are dominant causes. Overall, DRPs negatively affect therapeutic outcomes, increase the incidence of adverse effects, and elevate the risk of complications. Therefore, pharmacist-led interventions such as regular medication reviews, counseling, dose adjustment, and patient education are essential to prevent DRPs and improve treatment safety and effectiveness in chronic disease management.
Co-Authors Anisa Zanuba Ditha Zanetti Octavia Iglima Cikita Lina Permatasari Raditya Wedhagama Tuhfatul Ulya Vania Aisyah Aulia Syahda Haris Wulan Desi Rahmayanti Zaskia Rizky Maulana Zilfia Rahayu