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All Journal Jurnal Farmasi Indonesia
Rizky Abdulah
Department of Pharmacology and Clinical Pharmacy, Universitas Padjadjaran, Indonesia
Medicine & Pharmacology

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Profil Sitotoksik ekstrak Lithocarpus bancanus dan Fraksinya Terhadap Lini Sel Kanker Paru-Paru A549 Hilwan Yuda Teruna; Rudi Hendra; Retno Puji Lestari; Titania Tjandrawati Nugroho; Saryono Saryono; Jasril Jasril; Muhammad Almurdani; Rizky Abdulah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 1 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i1.128

Abstract

Lithocarpus bancanus is a medicinal plant used by communities in Riau Province, Indonesia. This plant is a tree locally known in the province as mempening. In this study, the cytotoxic activity profiles of the methanolic extract, n-hexane fraction, dichloromethane fraction, and ethyl acetate fraction from L. bancanus leaves were evaluated against human lung cancer cells (A549 cell line) using the MTT assay. IC₅₀ values were calculated from dose–response curves analyzed using the 4-parameter logistic (4PL) model. The results showed IC₅₀ values of 455.1, 361.9, 132.9, and 304.7 µg/mL for the methanolic extract, n-hexane fraction, dichloromethane fraction, and ethyl acetate fraction, respectively, with the dichloromethane fraction exhibiting relatively higher cytotoxic activity (IC₅₀ = 132.9 µg/mL). Cisplatin was used as the positive control and showed an IC₅₀ of 103.9 µg/mL. Meanwhile, the methanolic extract as well as the n-hexane and ethyl acetate fractions showed low cytotoxic activity, with IC₅₀ values greater than 300 µg/mL. Therefore, the dichloromethane fraction can serve as a basis for further isolation to identify bioactive anticancer compounds.
Co-Authors Hilwan Yuda Teruna Jasril Jasril Muhammad Almurdani Retno Puji Lestari Rudi Hendra Saryono Saryono Titania Tjandrawati Nugroho