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All Journal VALENSI JURNAL KIMIA SAINS DAN APLIKASI Jurnal Natur Indonesia AL KAUNIYAH Jurnal Penelitian Farmasi Indonesia Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Jurnal Edu Research Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Penelitian Farmasi Indonesia Biosaintifika: Journal of Biology & Biology Education Jurnal Sinergitas PkM & CSR JOPS (Journal Of Pharmacy and Science) JURNAL PHOTON Eksakta : Berkala Ilmiah Bidang MIPA Molekul: Jurnal Ilmiah Kimia Majalah Farmasetika Dinamika Lingkungan Indonesia Jurnal Farmasi Indonesia
Hilwan Yuda Teruna
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Sintesis dan Uji Antiinflamasi Senyawa (R)-3-(4-Florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol Serta Pengaruhnya terhadap Kerusakan Lambung Rullah, Kamal; Hasti, Syilfia; Hariani, Destawira; Utama, Putri Bela; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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Abstract

An in-vivo anti-inflammatory study of pyrazoline compound synthesized from chalcone has been carried out using Paw Edema method.Compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4, 5-dihidro-1H-pyrazole was synthesized by milling method in alkaline condition,with no solvent addition and was conducted under room temperature. Characterization of the synthesized compound was determined using1H-NMR and HR-MS spectrometer. As for anti-inflammatory study, suspension of compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol was administrated orally to white female mice (Rattus novergicus) with doses 20, 40, 80 mg/kg bw, respectively. Theresult showed that the compound with doses 40 and 80 mg/kg bw exhibited insignificant difference compared with standard drugs Celecoxiband Piroksikam (p>0,05). Futhermore, all doses of compound did not cause any damage of stomach organ of mice, which is given the same“ulcer index” (Iu) with negative control (Iu 2,00). Meanwhile, ulcer index for Celecoxib of Iu 35,99 and Piroksikam of Iu 70,01.
Aktivitas Antioksidan dan Antimikrobial dari Ekstrak Plectranthus amboinicus Teruna, Hilwan Yuda; Jose, Christine
Jurnal Penelitian Farmasi Indonesia Vol 1, No 2 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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Abstract

Plectranthus amboinicus or bangun-bangun is a traditional medicinal plant used for postpartum recovery in North Sumatera. The aims ofthis study were to detemine antioxidant and antimicrobial activity of leaves Plectranthus amboinicus. The leaves of Plectranthus amboinicuswere extracted with using n-hexane, ethyl acetate and methanol, successively. The extracts were tested to antioxidant activity assay usingDPPH with two fold dillution tehnique and ascorbic acid was used as standard. The antimicrobial activity was conducted using agar diffusionmethod against Escherichia coli, Staphylococcus aureus and Candida albicans. The Amoxsan used as positive control for antibacterialassay, while ketokenazole was for antifungi test. Extracted solvents were used as negative control. The n-hexane and ethyl acetate extractsdid not show any antioxidant activity. While, the IC 50 free radical DPPH of methanol extract was 90.96 mg/mL and ascorbic acid was 58.792mg/mL. The antimicrobial activity of n-hexane and Amoxsan againts Escherichia coli were 11.95 and 7.53 mm. The inhibition zone againtsStaphylococcus aureus were 11.30 and 11.57 mm. The antimicrobial activity of ethyl acetate and Amoxsan againts Escherichia coli were12.29 and 7.71 mm. The inhibition zone against Staphylococcus aureus were 13.72 and 11.57 mm. The n-hexane and ethyl acetate did notshow any antifungi activity towards Candida albicans. The methanol extract did not show any inhibition zone againts the selectedpathogens.
SINTESIS DAN UJI TOKSISITAS ANALOG FLAVANON TERSUBSTITUSI HALOGEN Rush, Ibnu; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Flavanones have been reported to possess many of interesting biological  activities  such as antimicrobe, antitumor, antioxidance, antiinflammatory, antimalaria, anticancer, and anti-HIV. In this research, a  halogenated flavanone 2-(3 -bromophenyl)chroman-4-one was synthesized by cyclization of  (E)-3-(3-bromophenyl)-1-(2-hydroxyphenyl)-2-propen-1-one  using  sodium  acetate as catalyst  under microwave  irradiation. The compound showed a good yield, and then was characterized by UV, IR and 1 H-NMR spectroscopy. The toxicity activity of this  compound was determined using Brine Shrimp Lethality Test (BSLT) method against larvae Artemia salina  Leach and showed a good activity with LC50  = 0,457 µg/mL. The result indicated that this compound  was potential  as anticancer.
Histology Structure of Lymph and Uterus of White Rat (Rattus norvegicus) Given with Nanas Bongsai (Ananas comosus var. microstachys L.) Fitmawati, Fitmawati; Saputra, Agus; Yohanes, Yohanes; Teruna, Hilwan Yuda; Nugraha, Dimas Pramita; Hamidi, Yulis
Biosaintifika: Journal of Biology & Biology Education Vol 10, No 1 (2018): April 2018
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v10i1.13596

Abstract

Nanas Bongsai (Ananas comosus var. microstachys L.) is an amazing herb which is used in traditional medicine by local people of Muara Lembu district as a potion to reduce pain while menstruation period for a women. The present work was designed to investigate its probable side effects on the histopathologic changes in limph and uterus tissues after treated with A. comosus var. microstachys L extract in female white rats. This is an experimental research consisted of five treatments and three repetitions. Treatment composed of two controls (P0 and P+) and given Nanas Bongsai extract with three different dosages. Histology result of lymph show that all treatments given with Nanas Bongsai with three different dosages have different diameter average of white pulp and there is no significant changes with normal control. While observation towards histology structure of endometrium thickness with dosage P1, dosage P2, dosage P3 is 206.333±33.486; 215.667±33.486; 197.667±60.871 respectively. The most thin endometrium layer found in treatment with dosage P3 compared to control P0. From this study showed that there is no toxic effect on uterus and lymph function of of Nanas Bonsai (A. comosus var. microstachys L.) at different doses, so the plant is secure for consumption by the community.
SINTESIS DAN UJI AKTIVITAS ANTIOKSIDAN SENYAWA 3-(4-METOKSIFENIL)-5-NAFTALEN-1-IL-1-FENIL-4,5-DIHIDRO-PIRAZOL Aisyah, -; Jasril, -; Teruna, Hilwan Yuda
Sistem Informasi Vol 8 No 01 (2017): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

A pyrazoline analog, 3-(4-methoxy-phenyl)-5-naphtalen-1-yl-1-phenyl-4,5-dihydro-pyrazole (PF CA-4OMe) has been synthesized via intermolecular cyclization between substituted chalcones and phenylhydrazine using glacial acetic acid as a catalyst under microwave irradiation. The structure of the compound was characterized based on the interpretation of UV, FTIR, HRMS, 1H-NMR, 13C-NMR, HSQC and HMBC spectra. The antioxidant test was carried out by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The result show that PF CA-4OMe was proved to have antioxidant activity with IC50 387,64 µg/mL.
SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 2’-HIDROKSIASETOFENON DAN HALOBENZALDEHID Ikhtiarudin, Ihsan; -, Lelani; Zamri, Adel; Teruna, Hilwan Yuda; -, Yuharmen
Sistem Informasi Vol 5 No 1 (2014): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Kalkon merupakan senyawa metabolit sekunder golongan flavonoid yang terdapat pada beberapa jenis tumbuhan. Senyawa ini dikenal memiliki berbagai bioaktivitas yang menarik. Dalam bidang sintesis, senyawa ini digunakan untuk mensintesis berbagai macam senyawa heterosiklik seperti benzodiazepin, pirazolin, flavanon, flavonol, dan senyawa turunan kalkon lainnya yang juga memiliki bioaktivitas yang menarik. Oleh karena itu, senyawa ini banyak dijadikan sebagai molekul target untuk keperluan pencarian senyawa-senyawa aktif sebagai kandidat obat, salah satunya adalah sebagai obat antikanker. Pada penelitian ini, tiga analog kalkon turunan 2’-hidroksiasetofenon dan halobenzaldehid telah disintesis menggunakan metode stirer dengan katalis KOH dan pelarut PEG-400. Struktur setiap produk dikarakterisasi dengan spektroskopi UV-Vis, FTIR, 1H NMR, 13C NMR, dan HRMS. Uji toksisitas dilakukan menggunakan metode Brine Shrimp Lethality Test (BSLT). Berdasarkan hasil uji BSLT, ketiga senyawa tersebut berpotensi sebagai senyawa antikanker dengan nilai LC50<200 μg/mL.
UJI AKTIVITAS ANTIOKSIDAN SENYAWA PIRAZOLIN 3-(2- METOKSI-FENIL)-5-NAFTALEN-1-IL-4,5-DIHIDRO-1H-PIRAZOL Nurlaili, -; Jasril, -; Teruna, Hilwan Yuda
Sistem Informasi Vol 8 No 2 (2018): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Pyrazoline compounds are reported to have many useful biological activities such as antimicrobials, antihyperglycemia, antioxidants, anti-inflammatory, anticancer and anticonvulsants. The pyrazoline analogues of 3- (2-methoxy-phenyl) -5-naphthalene-1-yl-4,5-dihydro-1H-pyrazol were synthesized usingglacial acetic acid as catalyst and assisted by microwave irradiation. The structures of the compounds were obtainedby UV, IR and HRMS spectroscopy data. Antioxidant activity test using DPPH method showed that pyrazoline compound had IC50 value of 27.41 μg/mL.
SINTESIS CALKON ((E)-1,3-DI(NAPHTHALEN-2-YL)PROP-2-EN-1-ONE) DAN AKTIVITASNYA SEBAGAI ANTIOKSIDAN Hilma, Rahmiwati; -, Jasril; Teruna, Hilwan Yuda
Sistem Informasi Vol 3 No 1 (2012): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Study on chalcone calkon (E)-1,3-di(naphthalen-2-yl)prop-2-en-1-one synthesis have been carried out with stirrer methode. These compounds can be used as intermediate compound to synthesize others compounds which was reported having antimicrobial, anti-inflammatory, anti-depressant, anti-tumour. The of chalcones synthesis vatives were reported in acid and alkali condition. In this study, chalcone and its derivates were synthesized by using stirrer method in alkaline condition in room temperature. the compounds subjected to somes analyses including melting point measurement, thin layer chromatography and HPLC. Scavenging free radical by using DPPH methode showed Scavenging free radical with LC50 >80 μg/ml min potent activity while the ascorbat acid LC50 89,79 μg/ml.
TRANSGLIKOSILASI ENZIMATIK SENYAWA ANTIOKSIDAN PINOCEMBRIN MENGGUNAKAN SELULASE TRICHODERMA RESEEI UNTUK PENINGKATAN BIOAVAILABILITASNYA Putri, Nova Rianti; Sepriani, Harni; Teruna, Hilwan Yuda; Nugroho, Titania Tjandrawati
Sistem Informasi Vol 5 No 1 (2014): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Flavonoid merupakan senyawa polifenol yang paling banyak terdapat di alam. Senyawa ini umumnya ditemukan dalam bentuk tidak terikat dengan gula (flavonoid aglikon). Salah satu contohnya adalah flavonoid aglikon pinocembrin. Flavonoid aglikon pinocembrin merupakan senyawa antioksidan, dan terbukti memiliki sifat antiangiogenesis, anti-inflamasi dan anti-tumor. Senyawa ini belum digunakan dalam jumlah banyak dikarenakan kelarutannya dalam air rendah, tidak stabil terhadap pengaruh cahaya, mudah teroksidasi, dan penyerapan di dalam usus rendah, serta memiliki rasa pahit. Sifat bioavailabilitas flavonoid aglikon ini dapat ditingkatkan dengan melakukan reaksi transglikosilasi. Transglikosilasi merupakan reaksi pemindahan unit gula ke akseptor yang memiliki gugus -OH. Flavonoid aglikon pinocembrin dapat bersifat stabil dan kelarutannya dalam air meningkat apabila diubah menjadi bentuk glikosida sebagai flavonoid glikosida melalui reaksi transglikosilasi secara enzimatik. Dalam penelitian ini transglikosilasi enzimatik pinocembrin dilakukan menggunakan bantuan enzim selulase Trichoderma reseei. Reaksi transglikosilasi dilakukan selama 30 jam pada suhu 40oC, menggunakan buffer asetat 0,05M pH 5, dan kecepatan pengocokan 170 rpm. Substrat carboxymethylcellulose (CMC) digunakan sebagai donor glikosil. Flavonoid glikosida hasil reaksi transglikosilasi dianalisis menggunakan High Performance Liquid Chromatography (HPLC). Hasil analisis HPLC menunjukkan enzim T. Reseei mampu melakukan reaksi transglikosilasi terhadap pinocembrin yang dapat dilihat dari adanya perubahan nilai waktu retensi dari produk transglikosilasi dibandingkan sebelum reaksi.
PENENTUAN KADAR TANIN DALAM PELARUT ETANOL 50% DARI KULIT BUAH MANGGIS (Garcinia mangostana L.) DENGAN BANTUAN SELULASE Trichoderma asperellum LBKURCC1 Miranti, -; Nugroho, Titania Tjandrawati; Teruna, Hilwan Yuda
Sistem Informasi Vol 6 No 02 (2016): Jurnal Photon
Publisher : Fakultas MIPA dan Kesehatan Universitas Muhammadiyah Riau

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Abstract

Tanin merupakan senyawa turunan polifenol yang memiliki berat molekul 500-3000 yang memiliki gugus hidroksi fenolik. Tanin yang terkandung dalam kulit buah manggis (Garcinia mangostana L.) dapat dimanfaatkan sebagai bahan aditif pada bahan industri cat, tekstil dan penyamak kulit. Penggunaan enzim selulase dalam proses ekstraksi tanin menggunakan alkohol 50% diharapkan mampu meningkatkan ekstrak kadar tanin. Kulit buah manggis diekstraksi dengan dan tanpa enzim selulase Trichoderma asperellum LBKURCC1 menggunakan pelarut bufer Naasetat 0,05 M pH 5,5 dan bufer-etanol dengan konsentrasi etanol 50%. Kandungan total tanin dianalisis menggunakan metoda Folin-Denis. Hasil penelitian menunjukkan kandungan tanin per gram kulit buah manggismeningkat secara signifikan (p<0,05) dengan penambahan etanol 50% dibandingkan tanpa etanol. Sedangkan kandungan tanin per gram kulit buah manggis dengan perlakuan tanpa dan menggunakan enzim selulase tidak memberikan perbedaan hasil yang nyata (p≥0,05).
Co-Authors ', Yuharmen - Aisyah - Miranti - Nurlaili -, Lelani Abdi Wira Septama Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Adel Zamri Agus Saputra Aini, Rhida - Aisyah Aisyah Aisyah, - Ardhi, Aulia Arjinal Arjinal Ary Puspita Christine Christine Jose Christine Jose Christine Jose Dahliarti ' Darian Alfatos Dede Indra Syari Destawira Hariani Desviana, Laila Desy Hariyanti Dimas Pramita Nugraha Diski Rahman Hakim Elfi Khairina, Elfi Elka Yuslinda Elsaria Karsana Elviyenti, Elviyenti Enda Mora ERWINA JULIANTARI, ERWINA Fajri Khatami Fifira Safitri Filza Yulina Ade Fitmawati Fitmawati Fitmawati Fitmawati Ganis Fia Kartika Hamidi, Yulis Harni Sepriani Hasmalina Nasution Hendra, Rudi Herix Sonata MS Ibnu Rush Ihsan Ikhtiarudin Ikhtiaruddin, Ihsan Islami, Deri Jasril ' Jasril , Jasril Jasril - Jasril Jasril Jismi Mubarrak Juwita Oktavani Kamal Rullah Kamal Rullah Karsana, Elsaria Laila Desviana Lelani - M Almurdani Marlinda, Sri Miranti Miranti Miranti, - Muhamad Afham Muhamad Rokhim Muttaqin, Fauzan Zein Nelma Yeni Neni Frimayanti Neri Sofiyanti Nova Rianti Putri NOVA WAHYU PRATIWI, NOVA WAHYU Nugraha, Dimas Pramita Nurlaili Nurlaili Nurlaili, - Pusaka, Semerdanta Putri Bela Utama Putri, Nova Rianti Putri, Rianti Rachel Fachira Rahayu, Wiwit Nur Rahim, Fatma Rahmiwati Hilma Retno Puji Lestari Rhida - Aini Rianti Putri Riki Setiawan Riki Setiawan Rissan Ramaesy Tobing Rohim, Muhammad Rohimatul Khodijah Rokim, Muhamad Rudi Hendra Rudi Hendra Rudi Hendra Rudi Hendra Sy Saputra, Agus Saputra, Agus Saryono Saryono Saryono Saryono Sepriani, Harni Shafira Melsonia shinta, dewi yudiana Shinta, Dewi Yudiana Siti Aisyah Siti Aisyah Sonata MS, Herix Syari, Dede Indra Syilfia Hasti Titania Tjandrawati Nugroho Tri Windarti Tri Windarti Veithzal Rivai Zainal Wahyuningsih Wahyuningsih Wina Noviana Widaningsih Yasthophi, Arif Yohanes Yohanes Yohanes Yohanes Yondra Arif D Yuana Nurulita Yuharmen ' Yuharmen - Yuli Haryani Yulis Hamidi Yum Eryanti Yum Eryanti Yuni Fatisa Yusmarini Yusmarini