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All Journal Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Vinolia Sandhyano Alkautsar Putri Walyatalattof
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Medicine & Pharmacology Nursing Public Health

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Peran Malassezia spp. pada Dermatitis Seboroik: Literature Review Vinolia Sandhyano Alkautsar Putri Walyatalattof; Hapsari Triandriyani; Hadi Firmansyah S.
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5646

Abstract

Seborrheic dermatitis (SD) is a chronic, recurrent inflammatory skin disorder that commonly affects sebaceous-rich areas such as the scalp and central face. Although multifactorial, Malassezia spp., particularly M. globosa and M. restricta, play a central etiologic role. These lipophilic yeasts, part of the normal skin microbiota, can become opportunistic pathogens under conditions of dysbiosis, excessive sebum production, or barrier dysfunction. Metabolic products such as oleic acid disrupt epidermal integrity and induce keratinocyte hyperproliferation, while activation of pattern recognition receptors (PRRs) triggers IL-23/IL-17–mediated immune responses. This review aims to elucidate the pathogenic role of Malassezia spp. in SD and its clinical implications. Understanding this host–microbe interaction allows for targeted therapy emphasizing antifungal and anti-inflammatory strategies. By elucidating these mechanisms, new therapeutic approaches, such as antifungal agents and anti-inflammatory treatments, can be designed to better manage SD and improve patient outcomes. Understanding the role of Malassezia in SD highlights the importance of a balanced skin microbiome in maintaining skin health and preventing chronic inflammatory skin disorders.  
Peran Malassezia spp. pada Dermatitis Seboroik: Literature Review Vinolia Sandhyano Alkautsar Putri Walyatalattof; Hapsari Triandriyani; Hadi Firmansyah S
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5664

Abstract

orrheic dermatitis (DS) is a chronic inflammatory skin disease that is commonly found in areas of the body rich in sebaceous glands, such as the scalp, central face, and upper chest. The disease is characterized by lesions that can be reddish plaques with oily scales, as well as itchy complaints. The etiology of DS is multifactorial, where in addition to genetic factors, environmental factors, and immunology also play an important role. One of the main factors in the pathogenesis of DS is infection by Malassezia spp., specifically M. globosa and M. restricta, which play a role in triggering an inflammatory response. This fungus, which is a normal flora on human skin, can transform into opportunistic pathogens under certain conditions, such as microbiota dysbiosis, increased sebum production, or disorders in the skin barrier. Malassezia's metabolic activities, such as oleic acid production, can impair the integrity of the epidermis and lead to the hyperproliferation of keratinocytes. In addition, activation of pattern-recognition receptors in immune cells triggers the inflammatory pathway IL-23/IL-17, which worsens inflammatory conditions in the skin. A deep understanding of the role of Malassezia spp. in the pathogenesis of DS is essential for determining accurate diagnosis and the development of more effective management, including the use of targeted antifungal therapies.
Co-Authors Hadi Firmansyah S Hadi Firmansyah S. Hapsari Triandriyani