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All Journal Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Hadi Firmansyah S
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Medicine & Pharmacology Nursing Public Health

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Peran Malassezia spp. pada Dermatitis Seboroik: Literature Review Vinolia Sandhyano Alkautsar Putri Walyatalattof; Hapsari Triandriyani; Hadi Firmansyah S
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5664

Abstract

orrheic dermatitis (DS) is a chronic inflammatory skin disease that is commonly found in areas of the body rich in sebaceous glands, such as the scalp, central face, and upper chest. The disease is characterized by lesions that can be reddish plaques with oily scales, as well as itchy complaints. The etiology of DS is multifactorial, where in addition to genetic factors, environmental factors, and immunology also play an important role. One of the main factors in the pathogenesis of DS is infection by Malassezia spp., specifically M. globosa and M. restricta, which play a role in triggering an inflammatory response. This fungus, which is a normal flora on human skin, can transform into opportunistic pathogens under certain conditions, such as microbiota dysbiosis, increased sebum production, or disorders in the skin barrier. Malassezia's metabolic activities, such as oleic acid production, can impair the integrity of the epidermis and lead to the hyperproliferation of keratinocytes. In addition, activation of pattern-recognition receptors in immune cells triggers the inflammatory pathway IL-23/IL-17, which worsens inflammatory conditions in the skin. A deep understanding of the role of Malassezia spp. in the pathogenesis of DS is essential for determining accurate diagnosis and the development of more effective management, including the use of targeted antifungal therapies.
Peran Multivitamin terhadap Pertumbuhan dan Kesehatan Rambut: Literature Review Nabila Ayu Imani; Hapsari Triandriyani; Hadi Firmansyah S
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5699

Abstract

Hair health is influenced by genetic, hormonal, environmental, and nutritional factors. Hair follicles have high metabolic activity that depends on adequate macro- and micronutrient supply. In recent years, multivitamin use has increased as a strategy to maintain hair health; however, its effectiveness and the risk of over-supplementation remain debated. This paper is a literature review of scientific articles, randomized controlled trials (RCTs), systematic reviews, and meta-analyses published within the last five years. Literature searches were conducted through PubMed, ScienceDirect, and Google Scholar using the keywords hair growth, multivitamin, nutrition, alopecia, supplementation. Macronutrients such as proteins (cysteine, methionine) and essential fatty acids play crucial roles in keratinization and follicular integrity. Micronutrients such as B-complex vitamins, vitamins D, A, C, and E, and minerals like zinc, iron, and selenium act as metabolic cofactors and antioxidants. Clinical evidence shows that multivitamin supplementation improves hair density and quality in individuals with suboptimal nutritional status, although excessive intake of vitamin A and selenium may trigger alopecia. Multivitamins are a promising adjunct therapy to support hair growth and health, especially in individuals with nutritional deficiencies. Their use should be rational, well-measured, and evidence-based to ensure optimal benefits while minimizing the risk of toxicity.
Co-Authors Hapsari Triandriyani Nabila Ayu Imani Vinolia Sandhyano Alkautsar Putri Walyatalattof