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All Journal Indonesian Journal of Global Health Research
Ricke Loesnihari
Universitas Sumatera Utara & Adam Malik Hospital

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Comparison of High Fluorescence Cell in Pediatric Patients with Acute Lymphoblastic Leukemia (ALL) and Infection Raden Sindhi Triagustin Kusuma Menthari; Malayana Rahmita Nasution; Ricke Loesnihari; Nindia Sugih Arto; Ranti Permatasari; Dewi Indah Sari Siregar`
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.431

Abstract

High Fluorescence Cell (HFC) is a cell with high nucleoplasmic and nucleic acid content, enabling it to emit a high fluorescent signal. Mind Ray Series BC 760 automated hematology analyzer uses a technology called Sheath Fluid (SF) Cube to detect these cells using the fluorescence staining method. An increase in HFC may be associated with atypical or pleomorphic lymphocytes caused by viral infection rather than immature or monomorphic lymphocytes caused by malignancy. Objective: The objective of this study is to determine the difference in high fluorescence cell in pediatric patients with Acute Lymphoblastic Leukemia (ALL) and infection at Adam Malik Hospital. Methods: This study is an observational analytical study with a prospective cohort design. The study sample was 35 people with a diagnosis of ALL of 15 people and infection of 20 people. This study was conducted on patients who came to the pediatric clinic and were hospitalized with a diagnosis of ALL and infection at Adam Malik Hospital who met the inclusion criteria and agreed to participate in this study. A high fluorescence cell blood test was performed.  criteria. A complete blood test of 2 ml of blood in an EDTA vacutainer was gently homogenized. Analysis with a full blood count (FBC) test was performed using an automated hematology analyzer (Mindray BC 760) to obtain the number of lymphocytes and high fluorescence cells. Descriptive statistical analysis was used for demographic data. Statistical analysis used the Mann Whitney statistical test. The research data were analyzed statistically with the help of SPSS and the difference was considered significant if p value <0.05. Results: From the study sample of 35 people, 24 boys (68.6%) and 11 girls (31.4%), with the mean age of 6 years old. The diagnosis of ALL was 15 people (42.9%) while patients with infection were 20 people (57.1%). The median absolute HFC  in ALL was 0.2 x 109/L, and the median in infection was 0.15 x 109/L. Conclusion: There was no significant difference between HFC in patients with ALL and infection (p=0.211).
Relationship Between HbA1c Levels and Atherogenic Index of Plasma in Diabetic Nephropathy Patients Adithya Nurliza Sitepu; Zulfikar Lubis; Muhammad Aron Pase; Nindia Sugih Arto; Ricke Loesnihari; Almaycano Ginting
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.577

Abstract

Diabetic nephropathy is the leading cause of kidney failure worldwide. Its incidence is comparable to that of cardiovascular disease (CVD), with macrovascular complications remaining the main cause of death among diabetic patients. The Atherogenic Index of Plasma (AIP) is an independent marker and predictor of CVD. AIP indicates risk even when other atherogenic risk factors are normal, categorized as low risk (AIP < 0.11), intermediate risk (AIP 0.11–0.21), and high risk (AIP > 0.21). This study aims to explore the relationship between Glycated Hemoglobin (HbA1c) levels and AIP in patients with diabetic nephropathy to identify the risk of CVD complications. It used a prospective analytical design with a cross-sectional approach, conducted at Adam Malik Hospital, Medan, from February to May 2025. Forty-three outpatients with diabetic nephropathy who met the inclusion criteria were selected using a consecutive sampling technique. Patients were assessed for HbA1c, triglycerides, HDL, and urinary albumin-to-creatinine ratios. AIP was calculated by taking the logarithm of (triglycerides/HDL). Data analysis involved Pearson and Spearman correlation tests. A significant positive correlation was found between HbA1c and AIP (r = 0.670, p = 0.000), as well as between HbA1c and triglycerides (r = 0.398, p = 0.008). A significant negative correlation was observed between HbA1c and HDL (r = -0.648, p = 0.000). However, there was no significant correlation between HbA1c and ACR, nor between ACR and AIP (p > 0.05). In conclusion, higher HbA1c levels are associated with increased AIP levels, which elevate the risk of CVD, characterized by rising triglycerides and decreasing HDL.
Comparison of PT and aPTT Results in Icteric Samples using Optical and Electromechanical Methods Ria Zulfa; Dewi Indah Sari Siregar; Nelly Elfrida Samosir; Ricke Loesnihari; Ranti Permatasari; Sylvia Youvella
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1122

Abstract

Prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests are important screening tests for assessing coagulation pathway function and monitoring anticoagulant therapy. These tests use a coagulation analyzer with different detection methods, namely optical and electromechanical methods. The working principles of the two methods can cause variations in test results, especially in samples with icteric interference. Therefore, it is necessary to evaluate the comparison of PT and aPTT values in icteric samples using both methods.  This study aimed to evaluate the differences in PT and aPTT values in icteric samples using optical and electromechanical methods. This study used a prospective analytical design with a cross-sectional approach, conducted at Adam Malik Hospital, Medan, from July to August 2025. A total of 69 samples that met the inclusion criteria were selected using sequential sampling techniques. Each sample is tested for PT and aPTT using optical and electromechanical methods. The results of each test were analyzed using the Mann-Whitney, Kappa, correlations tests, and Bland-Altman plots. Significant differences were observed in PT and aPTT values between the optical and electromechanical methods (p<0.001), while INR values showed no significant difference (p=0.426). Interpretation agreement was moderate for PT (κ=0.599; p<0.001) and strong for aPTT (κ=0.661; p<0.001). Despite numerical differences, both methods provided comparable clinical interpretations, and total bilirubin showed no association with PT or aPTT values. The optical and electromechanical methods produced comparable clinical interpretations despite differences in PT and aPTT values, and total bilirubin levels were not associated with PT or aPTT results.
Co-Authors Adithya Nurliza Sitepu Almaycano Ginting Dewi Indah Sari Siregar Dewi Indah Sari Siregar` Malayana Rahmita Nasution Muhammad Aron Pase Nelly Elfrida Samosir Nindia Sugih Arto Raden Sindhi Triagustin Kusuma Menthari Ranti Permatasari Ria Zulfa Sylvia Youvella Zulfikar Lubis