Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Pharmaqueous Indonesian Journal of Global Health Research
Asep Nurrahman
Universitas Al-Irsyad Cilacap
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Development of a Herbal Formula of Breadfruit (Artocarpus altilis) Leaf Extract for Fluid Retention Management in Congestive Heart Failure Kasron Kasron; Susilawati Susilawati; Asep Nurrahman
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1720

Abstract

Congestive heart failure (CHF) is characterized by persistent fluid retention leading to edema and dyspnea, which significantly impair functional capacity and increase hospital readmission rates. Although loop and thiazide diuretics are effective in decongestion, long-term use frequently results in electrolyte imbalance, renal dysfunction, and diuretic resistance. Breadfruit leaf (Artocarpus altilis), containing flavonoids, tannins, and saponins with natural diuretic mechanisms, has been traditionally used to reduce fluid accumulation and edema. This study aimed to evaluate the effectiveness of standardized breadfruit leaf extract in improving fluid retention and dyspnea among CHF patients. This study aimed to evaluate the effectiveness of standardized breadfruit leaf (Artocarpus altilis) extract in reducing fluid retention and improving dyspnea in patients with congestive heart failure (CHF). A quasi-experimental one-group pretest–posttest design was conducted on 15 CHF patients who received standardized breadfruit leaf extract for five consecutive days. Parameters measured included body weight and dyspnea severity using the Borg Modification Scale. Data were analyzed using paired t-tests. A statistically significant reduction in body weight was observed after intervention (61.9 ± 5.2 kg to 61.7 ± 5.2 kg; p = 0.005), indicating decreased fluid retention. Dyspnea scores also showed significant improvement (5.6 ± 0.6 to 4.5 ± 0.8; p = 0.001), reflecting meaningful clinical relief in respiratory symptoms associated with congestion. Standardized breadfruit leaf extract demonstrated beneficial effects in reducing body fluid accumulation and improving dyspnea among CHF patients, supporting its potential as a complementary therapy with minimal adverse effects.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Krim Ekstrak Daun Kunyit (Curcuma domestica Val) Terhadap Staphylococcus aureus ATCC 25923 Asep Nurrahman; Rini Susanti; Tatang Tajudin
Pharmaqueous: Jurnal Ilmiah Kefarmasian Vol. 4 No. 1 (2022): Volume 4, Nomor 1, Mei 2022
Publisher : Universitas Al-Irsyad Cilacap

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36760/jp.v4i1.223

Abstract

Daun Kunyit (Curcuma domestica Val.) mengandung senyawa alkaloid, steroid, triterpenoid, tanin, dan saponin. Penelitian ini bertujuan untuk mengetahui formulasi yang baik pada pembuatan Krim Ekstrak Daun Kunyit (Curcuma domestica Val.) dan aktivitas antibakteri. Penelitian menggunakan metode eksperimental dengan variasi konsentrasi Ekstrak Daun Kunyit (Curcuma domestica Val.) yaitu F1 (40 %), F2 (60 %), dan F3 (80 %). Karakteristik fisik yang diamati berupa organoleptis, homogenitas, pH, viskositas, daya sebar, daya lekat, dan tipe krim. Hasil uji organoleptis F1, F2 dan F3 krim bau khas kunyit, krim berbentuk semisolid, tekstur halus, krim berwarna hijau (F1), hijau pekat (F2), hijau hijau kehitaman (F3), pada uji homogenitas krim semua formulasi (F1, F2, F3), bersifat homogen, pada uji pH semua formulasi hasil pH 6. Pada uji viskositas semua formulasi sesuai dengan standar viskositas, sedangkan pada uji daya sebar krim formulasi terbaik pada F1, akan tetapi pada F3 tidak memenuhi standar daya sebar yang baik dan pada uji daya lekat krim formulasi terbaik ditunjukan pada F3. Serta pada uji tipe krim hasilnya yaitu minyak dalam air (M/A). Hasil pengujian antibakteri sediaan krim terdapat aktivitas antibakteri hasil diameter zona hambat bakteri pada F1 (15 mm), F2 (18 mm) dan F3 (19 mm).
Co-Authors Kasron Rini Susanti Susilawati Susilawati Tatang Tajudin