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All Journal Window of Health : Jurnal Kesehatan
Gabena Indrayani Dalimunthe
Department of Pharmacy, Faculty of Pharmacy, Universitas Muslim Nusantara Al-Washliyah, Medan, North Sumatra, Indonesia
Medicine & Pharmacology Nursing Public Health

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Formulation and Antipyretic Evaluation of Papaya Root Extract (Carica papaya L.) Hydrogel Patch in Male Mice Gabena Indrayani Dalimunthe; Zulmai Rani
Window of Health : Jurnal Kesehatan Vol 9 No 3 (July, 2026)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.vi.3046

Abstract

Papaya root (Carica papaya L.) has traditionally been used to manage fever, but its development as a standardized topical antipyretic preparation remains limited. Therefore, this study aimed to formulate hydrogel patches containing 5%, 10%, and 12.5% ethanolic papaya root extract and evaluate their physicochemical characteristics and antipyretic activity in DPT-HB vaccine-induced febrile male mice. Twenty-five mice (Mus musculus L.) were randomly allocated to a negative control, a positive control, and three extract-patch groups (n = 5 each). Rectal temperature was measured before fever induction and at 0, 15, 30, 45, and 60 minutes after treatment. Data were analyzed by one-way ANOVA followed by Tukey’s HSD test. All formulations were homogeneous, semi-solid, brownish patches with pH values of 5.7–5.8 and viscosities of 176,000–236,000 cP. At 60 minutes, temperatures were 38.2°C in the negative control, 36.9°C in the positive control, 36.7°C in the 5% group, 36.9°C in the 10% group, and 36.6°C in the 12.5% group. Significant differences were found among groups (p = 0.033), and the 12.5% formulation showed the largest observed temperature reduction. Papaya root extract can therefore be incorporated into a hydrogel patch with acceptable physicochemical characteristics and preliminary antipyretic activity.
Co-Authors Zulmai Rani