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All Journal Journal of Agromedicine and Medical Sciences Window of Health : Jurnal Kesehatan JOPS (Journal Of Pharmacy and Science) Journal Syifa Sciences and Clinical Research (JSSCR) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Dunia Farmasi Jurnal Ilmiah Manusia dan Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Aisyah : Jurnal Ilmu Kesehatan Community Development Journal: Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Chemical Science and Technology Jurnal Kesehatan Tambusai JUKESHUM: Jurnal Pengabdian Masyarakat Jurnal EduHealth FORTE JOURNAL Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi International Journal of Health and Pharmaceutical (IJHP) Sciences of Pharmacy FARMASAINKES PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal Journal of Pharmaceutical and Sciences. Media Farmasi Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Jurnal Akademika Kimia Jurnal Sains dan Kesehatan
Zulmai Rani
Universitas Muslim Nusantara Al-Washliyah, Medan, Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Veterinary Other

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Utilization Of Glycerol By Product From Transesterification Of Waste Cooking Oil As A Cosurfactant In Nanocream Preparation Rani, Zulmai; Julia Reveny; Urip Harahap
International Journal of Science, Technology & Management Vol. 2 No. 4 (2021): July 2021
Publisher : International Journal of Science, Technology & Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v2i4.264

Abstract

Waste cooking oil (used cooking oil ) is oil derived from leftover cooking oil for frying food. Waste cooking oil is still considered as waste by some people and waste cooking oil that should not be suitable for consumption is sometimes still widely reused in food processing, this can endanger health and reduce the nutritional value of food. In order to be used and have economic value, it is overcome by synthesizing waste cooking oil into glycerol so it can be used as cosurfactant. Besides as cosurfactant, this waste cooking oil glycerol also can be used for various chemical industies, foods, cosmetics, and pharmaceuticals industries. For cosmetic preparation, it can make a nanocream preparation. The purpose of this research was to utilize waste cooking oil into a glycerol which is used as a cosurfactant, to characterize the synthesis results based on IR Spectroscopy data and to formulate it to nanocream preparation. The research was conducted in an experimentally by making glycerol from side product of waste cooking oil. Separating glycerol process conducted by transesterification reaction. Glycerol of waste cooking oil by product was characterized with IR Spectroscopy and evaluated include organoleptic, glycerol contents, density, viscosity, ash content, and moisture content. Formulation of nanocream preparation using 30% of Tween 80 as surfactant, glycerol by-product as cosurfactant 7,5% concentration, and 20% of VCO as oil phase. The nanocream preparation was measured for its particle size with the aim of being able to determine the particle size of the formula to form nanoparticle size. The results showed that glycerol of waste cooking oil by product shows the presence of OH, CH-aliphatic, C=O carbonyl and C-O. particle size of nanocream preparation obtained was 397,76 nm. Based on the result of this research, the conclusion is glycerol of waste cooking oil by-product can form nano size with presence of glycerol as cosurfactant. The particle size of the nanocream preparation obtained was still in the nanocream requirement range, namely 20-500 nm.
Extraction And Phytochemical Screening of Ethanol Extract And Simplicia of Moringa Leaf (Moringa Oleifera Lam.) From Sidikalang, North Sumatera Ricky Andi Syahputra; Ani Sutiani; Pasar Maulim Silitonga; Zulmai Rani; Amelia Kudadiri
International Journal of Science, Technology & Management Vol. 2 No. 6 (2021): November 2021
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v2i6.381

Abstract

Moringa leaf is a plant that has many uses that comes from the family Moringaceae and it is a tropical plant that is familiar to Indonesian people. Pharmacologically, this plant extract is reported to have antimicrobial and fungicide and it is rich in antioxidants. This metabolite compound contained in Moringa leaves has the potential as an antioxidant, antibacterial, functional and others. This study aims to determine the simplicia characterization of Moringa leaves and to determine the secondary metabolites contained in Moringa leaves, both Moringa leaf powder and Moringa leaf extract. The method of this research is experimental including the simplicia making and ethanol extract of Moringa leaves by maceration method, simplicia characterization and phytochemical screening. The results of the simplicia characterization of Moringa leaves for ethanol soluble extract content was 10,9% and water-soluble extract content was 15,8%, ash content was 9,6% and acid insoluble ash content was 0,6% and water content was 8%. The results of this study also showed that the simplicia powder and ethanol extract of Moringa leaves contained flavonoid, tannin, alkaloid, steroid and saponin.
Uji Efektivitas Mukolitik Ekstrak Umbi Bawang Dayak (Eleutherine bulbosa (Mill) Urb) Robiatun Rambe; Zulmai Rani; Nur Ain Thomas
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.7041

Abstract

Dayak Onions are a typical Borneo plant that have been used by generations of Dayaks as herbal medicine. Empirically, tubers can be used as cough medicines. The purpose of this study was to determine the mucolytic effect of Dayak onion tuber extract by in vitro and the concentration range which gaves an equivalent effect with the effect of 0.1% acetylcysteine. This study conducted extraction using maceration. The test solution was made with a concentration of 0.5%, 1%, and 1.5% mixed with a mucus-phosphate buffer pH 7 20:80. The test solution was incubated for 30 minutes at 37oC. Further, positive control used was 0.1% acetylcysteine drug and the negative control was mucus solution without extract. Viscosity values obtained were analyzed using the One-way Anova statistical test with a confidence level of 99% (α 0.01). Based on the results, it was revealed that the extract of Dayak tuber with a concentration of 0.5%, 1%, and 1.5% showed a significant difference and a concentration of 0.5%.  Mucolytic effectiveness was better than positive controls (acetylcysteine).
Phytochemical Screening And Antioxidant Activity Testing Of Porang (Amorphophallus Muelleri Blume) Leaf Ethanol Extract From Kuta Buluh Region, North Sumatera Ainil Fithri Pulungan; Ridwanto Ridwanto; Gabena Indrayani Dalimunthe; Zulmai Rani; Rahma Dona; Ricky Andi Syahputra; Robiatun Rambe
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (192.501 KB) | DOI: 10.51601/ijhp.v3i1.141

Abstract

Porang (Amorphallus muelleri Blume) is one type of tuber plant that has the potential to be developed in Indonesia. Porang plants have been reported to contain chemical compounds that have antioxidant activity. This research was conducted on the leaves of the porang plant with the aim of knowing the antioxidant activity, characterization, and phytochemical profile of the compounds contained therein. Compound identification and characterization were performed using standard methods, and antioxidant activity was determined using the DPPH (1,1- Diphenyl-2-picrylhydrazyl ) method. The results of the identification of chemical compounds showed that the ethanol extract of porang leaves contained chemical compounds of alkaloids, flavonoids, tannins, saponins, and steroids. The results of the examination of the simplicia characterization of porang leaves included the soluble ethanol content of 33.93%, the water soluble extract content of 17.3%, the ash content of 5.58%, the acid insoluble ash content of 0.235% and the water content of 8%. From the results of the simplicia characterization, it shows that the results meet the specified requirements. The results showed that the ethanol extract of porang leaves had antioxidant activity with an IC50 value of 93.04 µg/mL, which in this case is included in the category of strong antioxidant activity. Meanwhile, as a comparison, Vitamin C was used, which has an IC50 value of µg/mL, which is included in the category of very strong antioxidant activity.
Formulation And Evaluation Of Hand Sanitizer Gel From Clove Flower Extract (Eugenia aromatica L.) Robiatun Rambe Robiatun; Aswan Pangondian; Ratih Paramitha; Zulmai Rani; Evi Depiana Gultom
International Journal of Science, Technology & Management Vol. 3 No. 2 (2022): March 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i2.472

Abstract

Clove flower (Eugenia aromatica L.) is a plant from the Myrtaceae family, the compounds contained in clove flowers are flavonoids, tannins, alkaloids, and saponins that can function as antibacterial. In addition, clove flowers also function as analgesic, anti-inflammatory, antimicrobial, antiviral, antifungal, antiseptic, antispasmodic, antiemetic, stimulant, and local anesthetic. The purpose of this study was to determine does clove flower extract (Eugenia aromatica L.) could be used as a hand sanitizer gel preparation. Clove flower simplicia powder was extracted with ethanol 96% by maceration. The extract obtained was then screened for phytochemicals, then formulated in the form of a hand sanitizer gel, by adding clove flower extract to each formula with different concentrations. The clove flower extract concentrations used were 5%, 10%, and 15%. After the hand sanitizer gel preparation was formed, the clove flower extract was then tested for the stability of the gel preparation. The clove flower extract obtained was 116.4 grams of thick extract. The results of phytochemical screening of clove flower extract showed the presence of secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. Based on the evaluation of the hand sanitizer gel preparation, clove extract showed that it was physically stable during storage. Based on the acceptability or liking test conducted on 20 respondents using a questionnaire sheet, the results showed that the respondents really liked the aroma of formula F3.
Antioxidant Activity Test of Barangan Banana Hump’s Ethanol Extract (Musa Paradisiaca (L.)) with DPPH (1,1 Diphenyl-2-Picrylhydrazyl) Method Virda Nurmazela; Ridwanto Ridwanto; Zulmai Rani
International Journal of Science, Technology & Management Vol. 3 No. 5 (2022): September 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i5.610

Abstract

This study aims to determine the secondary metabolites contained in Barangan banana weevil (Musa paradisiaca (L.)) and antioxidant activity based on the IC50 value. The stages of this research include processing plant materials, making ethanol extracts, characterization examinations, phytochemical screening, and testing the antioxidant activity of Barangan banana weevil. The ethanol extract of Barangan banana weevil was processed by the maceration method using 96% ethanol, and the antioxidant activity was tested using the DPPH method. The results showed that the ethanol extract of Barangan banana weevil contained chemical compounds such as alkaloids, glycosides, flavonoids, saponins, tannins, and triterpenoids. The determination of the antioxidant activity of Barangan banana weevil obtained an IC50 value of 180.8 µg/mL. This means that the ethanol extract of Barangan banana weevil contains secondary metabolites and has the potential as an antioxidant with a weak category.
Utilization Of Chitosan As A Natural Preservative Against Catfish Nurhayati Nurhayati; Ridwanto Ridwanto; Anny Sartika Daulay; Ricky Andi Syahputra; Zulmai Rani
International Journal of Science, Technology & Management Vol. 3 No. 5 (2022): September 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i5.614

Abstract

Shrimp in Indonesia are generally exported abroad after removing the head, tail, and skin. One alternative to the use of shrimp shell waste that has high economic value is processing shrimp shells into chitosan. The purpose of this study was to determine the shelf life of catfish using chitosan and to determine the optimal concentration of chitosan in catfish preservation. Chitosan applied to catfish showed that in the addition of a 0% chitosan solution, it had a shelf life of up to day 2 for 48 hours for a 0.5 solution; 1; 1.5 and 2% shelf life up to day 5 or for 120 hours. The most optimal concentration of chitosan for use in catfish is a 2% chitosan solution, and the total plate number (ALT) test meets the requirements of the SNI standard so that it can still be consumed.
Caffeine Levels from Various Types of Coffee Drink Packaging Circulated in the Medan City Market Were Examined Using a UV Spectrophotometry Method Gabena Indrayani Dalimunthe; Adli Nuzula Rahmah; Zulmai Rani; Yayuk Putri Rahayu
Indonesian Journal of Chemical Science and Technology (IJCST) Vol 5, No 2 (2022): JULI 2022
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v5i2.37465

Abstract

Coffee drinks are drinks that come from the processing and extraction of coffee beans. One of which is caffeine. Coffee contains approximately 24 of the most important substances. The purpose of this study was to determine the level of caffeine in coffee drinks from various types of packaging. The research stages include sample collection and preparation; identification of caffeine content; and examination of caffeine levels using UV spectrophotometry. The results showed that the three samples of coffee drinks sold at the minimarket in Jermal, Medan contained caffeine, and the levels of caffeine in coffee drinks were 26,352±0,292 mg/100mL (Sample A), 15,179±0,286 mg/100mL (Sample B), and 7,965±0,98 mg/100mL (Sample C). The caffeine content obtained meets the requirements of SNI, where the maximum amount of caffeine that can be consumed by the public in a day based on SNI is 50 mg–150 mg.
Cytotoxicity Test of Cocoa Leaf Ethanol Extract (Theobroma Cacao L.) With Brine Shrimp Lethality Test (BSLT) Method Zulmai Rani; Ridwanto Ridwanto; Dikki Miswanda; Rafita Yuniarti; Ani Sutiani; Ricky Andi Syahputra; Reza Irma
Indonesian Journal of Chemical Science and Technology (IJCST) Vol 5, No 2 (2022): JULI 2022
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v5i2.37452

Abstract

Cancer is a disease characterized by uncontrolled cell division and the ability of these cells to invade other biological tissues, either by direct growth in adjacent tissues or by migration of cells to distant sites. The purpose of this study was to determine the class of secondary metabolites contained in the ethanol extract of cocoa leaves and their cytotoxicity by looking at the LC50 value using the Brine Shrimp Lethality Test (BSLT) method. This research includes phytochemical screening of ethanol extract and the BSLT method by looking at the number of deaths of Artemia salina leach larvae (LC50). The results of phytochemical screening tests showed that the cocoa leaves contained flavonoids, alkaloids, tannins, saponins, steroids, and glycosides. The cytotoxicity test with probit analysis showed an LC50 value of 269,15 µg/mL, so it was concluded that the ethanol extract of cocoa leaves was toxic and had potential as an anticancer.
UJI TOKSISITAS KITOSAN CANGKANG KERANG BULU (Anadara antiquata) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Nadila Indra Sepvina; Ridwanto Ridwanto; Zulmai Rani
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 2 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v7i2.1023

Abstract

Shellfish is one of Indonesia's fishery commodities which is increasing every year, one of which is blood clams and feather shells, which are easily found in Southeast Asia and East Asia. Shellfish also have great potential so that it has an impact on the increasing waste that is allowed to accumulate without any handling of the pollution that exists in the environment and society. One alternative to the use of waste from feather shells to have a high use value is to isolate it into chitosan. The purpose of this study was to investigate the utilization of shellfish waste into chitosan and to determine the LC50 value of the chitosan produced. The analysis carried out was the toxicity test of chitosan from shellfish shell waste on Artemia salina Leach shrimp larvae using the Brine Shrimp Lethalitiy Test (BSLT) method with various concentrations of 100; 250; 500; 750; and 1000 µg/mL, and determining the value of LC50 by probit analysis. Based on the results of the toxicity test of chitosan from shellfish waste, the LC50 value was µg/mL. These results indicate that chitosan from shellfish waste has no toxic effect on Artemia salina Leach shrimp larvae.
Co-Authors A'dilah, Nur Abadi, Hafizhatul Adjelie, Tiara Adli Nuzula Rahmah Adyani Maulinda Afridah, Nurul Ilmi Ahmad Rasyid Ridho Alviana, Liya Amelia Kudadiri Andjelie, Tiara Ani Sutiani Ani Sutiani Anny Sartika Daulay Anny Sartika Daulay Anny Sartika Daulay Aprilia, Hijjatun Arifin, Khairil Fikri Arrosty, Muflizah Asep Trizaldi Athaillah, Athaillah Audry Pratiwi Aulia Fitri Aulia Fitri, Aulia Auza , Maharani Azhar, Gustika Bambang Hermanto Bambang Hermanto Beby Noplya Wulandari BJ Sutrisna Chandra, Putra Christica Ilsanna Surbakti Daulay, Anny S. Dea Anggreini Denny Satria Dewi, Sri Harti Dikki Miswanda Dinda Sari Utami Emma Susanti Erma Susanti Evi Depiana Gultom Evi Depiana Gultom Evi Depiana Gultom Fadhlah Al-Uyun Nasution Fajri, Fajrilda Aqilah Fatma Dwi Jati Fauziah Erna Witular Panggabean Ferendina, Imelda Fithri Pulungan, Ainil Fitri, Nurul Fitri, Raissa Gabena Indrayani Dalimunthe Ginting, Grace Anastasia br Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Hanafis Sastra Winata Harahap, Sumiyarni Haris Munandar Nasution Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hariyadi Dharmawan Syahputra Hasibuan , Fika Miah Sasmitha Hasibuan , Nabila Hasim Hasibuan, Zulfiana Ramadhani Hindri Syahputri Humaira, Annisa Husna, Miftahul Indrayani, Gabena Inna Myesha Julia Reveny Karo Sekali, Elva Swandi Kasta Gurning Khairunnisa , Ardina Khan, Sahrani Nazwa Kiki Rawitri Kiki Rawitri Lestari, Amanda Putri Lestari, Kurnia Dwi Lilik Septiana Lilik Septiana Linda, Rosa Lubis, Minda Sari Lubis, Nurazizah M. Alfaruqi Maghfirah, Dini Mainal Furqan Maryanti Yuza Matondang , Fikriyah Hafni Maulana Putri, Yasinta Mira Febrina, Mira Monica Suryani Moondra Zubir Muhammad Agus Muljanto Muhammad Amin Nasution Muhammad Fauzan Lubis Muhammad Yunus Muhammad Yunus Mukti, Ridho Munandar, Verissa Nadila Indra Sepvina Nasri Nasri Nasri Nasri Nasri Nasri, Nasri Nazuhra, Oca Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggita Ningtias, Anggitha Nomi Noviani Nur Ain Thomas Nur, Hijrotun Nurdalilah, Nurdalilah Nurhayati Nurhayati Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Ovalina Sylvia Br. Ginting Pasar Maulim Silitonga Pertiwi, Rahma Pitaloka, Syifa Amilia Puteri, Cut Intan Annisa Putra, Andhika Dharma Putri Khairani Rafita Yuniarti Rahma Dona Raissa Fitri Rambe, Robiatun Ratih Paramitha Rawitri, Kiki Reza Irma Ricky Andi Syahputra Ricky Andi Syahputra Ridho, Ahmad Rasyid Ridwanto Ridwanto Rinda Sari, Sylvi Ritonga , Nur Sakina Rizki, Dewi Rizki, Vitri Dea Robiatun Rambe Rukmana, Siti Sagala, Hasel Untung Bersinar Samran, Samran Sari Lubis, Winda Sari, Farida Sari, Syilvi Rinda Sari, Sylvi Rinda Sartika Daulay, Anny Savitri, Novia Herma Septiana, Lilik silalahi, zahra salsabila Sindi, Sindi Sipahutar, Rizki Anjani Siregar , Misbah Siti Anisa Siti Rahmah Siti Rahmi Ningrum Sony , Suyefri Sri Wahyuni Sri Wahyuni Sri Wahyuni Suci, Nurul Sulwiyatul K Sani Supiyani, Supiyani Syafa Nadira Ashiilah Syahputra, Ricky Andi Syarifah Nadia Syilfia Hasti Tania, Chyntia Glori Tarigan, Eni Surabini Urip Harahap Uswatun Nisa, Uswatun Vera Estefania Kaban Virda Nurmazela Widya, Rizka Yayuk Putri Rahayu Yayuk Putri Rahayu Yuli Haryani Yuliatil Adawiyah Harahap Yuniarti , Rafita Yuniarti, Rafita Zahira Ahmad, Madani Ziza Putri Aisyia Fauzi Zulfikri Zulfikri Zulhij, Fizrya