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All Journal Biomedical Journal of Indonesia Narra J
Shirly Gunawan
Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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The Role of Diabetes Mellitus Panel on Kidney Function Decline in Elderly Population: Cross-Sectional Study Shirly Gunawan; Robert Kosasih; Yohanes Firmansyah; Alexander Halim Santoso; Bryan Anna Wijaya; Kresna Bambang; Farhan Pratomo
Biomedical Journal of Indonesia Vol. 12 No. 1 (2026): Vol 12, No 1, 2026
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i1.293

Abstract

Introduction. Chronic kidney disease (CKD) is a major public health issue, particularly among the elderly, where metabolic disturbances accelerate renal decline. Diabetes mellitus contributes to kidney dysfunction through insulin resistance and altered glycemic control. This study investigates the relationship between diabetes-related parameters—fasting blood glucose, HbA1c, fasting insulin, HOMA-IR, and kidney function, as measured by estimated glomerular filtration rate (eGFR) in an elderly population. Methods. A cross-sectional analytic study was conducted among 82 elderly residents of Bina Bhakti Nursing Home. Venous blood samples were collected to assess fasting blood glucose, HbA1c, fasting insulin, and HOMA-IR. Kidney function was estimated using the CKD-EPI equation. Results. Age showed a significant negative correlation with eGFR (r = –0.266, p = 0.016), indicating age-related renal decline. HOMA-IR (r = 0.247, p = 0.025) and fasting insulin (r = 0.224, p = 0.043) demonstrated weak but significant positive correlations with eGFR. Conversely, fasting glucose (r = 0.055, p = 0.623) and HbA1c (r = 0.029, p = 0.795) had negligible, non-significant correlations with eGFR, suggesting limited predictive value for renal impairment. Insulin growth factor exhibited a weak, non-significant negative correlation (r = –0.104, p = 0.355). Conclusion. Age remains a key determinant of declining kidney function in the elderly. Insulin resistance markers showed mild but unexpected associations, warranting further longitudinal studies to confirm these findings and explore underlying mechanisms.
Maternal medical conditions and parenting styles as determinants of child emotional, developmental, and growth outcomes: A community-based pilot study in urban slum areas Ernawati Ernawati; Yohanes Firmansyah; Alexander H. Santoso; Fransisca IR. Dewi; Agustina Agustina; Monika Monika; Bryan A. Wijaya; Diana Dinali; Shirly Gunawan; Hendsun Hendsun
Narra J Vol. 6 No. 3 (2026): December 2026 (In Press)
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i3.3143

Abstract

Children living in urban slums are exposed to intersecting biological and psychosocial vulnerabilities, yet the relative roles of maternal health and parenting in child development remain unclear. This study aimed to examine correlations of maternal health characteristics and parenting styles with child developmental, emotional-behavioral, and nutritional measures and to explore their structural relationships. A community-based cross-sectional pilot study was conducted among mother–child dyads in West Jakarta, Indonesia. Child measures included the Strengths and Difficulties Questionnaire (SDQ), Pre-Screening Developmental Questionnaire (PDQ), and nutritional-status deviation. Maternal health characteristics included blood pressure, anthropometry, body composition, hemoglobin, fasting blood glucose, uric acid, and lipid profiles. Parenting styles were assessed using the Parenting Styles and Dimensions Questionnaire (PSDQ). Spearman’s rank correlation and Partial Least Squares–Structural Equation Modeling were applied. Permissive parenting was negatively correlated with hyperactivity (r=−0.260; p<0.05), while no significant correlations were observed for authoritarian or authoritative parenting. Developmental-deficit scores were positively correlated with several maternal measures, including systolic blood pressure (r=0.401; p<0.01), body weight (r=0.340; p<0.01), fasting blood glucose (r=0.356; p<0.01), and triglycerides (r=0.299; p<0.05), and negatively correlated with high-density lipoprotein (r=−0.413; p<0.01). Maternal hemoglobin was negatively correlated with emotional-problem scores (r=−0.263; p<0.05). The PLS-SEM models explained 25.2–29.6% of the variance in SDQ scores and 23.3–26.0% in PDQ developmental-deficit scores, with maternal health-related pathways showing greater consistency across models than parenting-related pathways. Maternal health characteristics were more consistently related to child developmental and emotional-behavioral measures than parenting styles in this urban-slum population. These findings support further longitudinal studies integrating maternal health and parenting factors.
Co-Authors Agustina Agustina Alexander H. Santoso Alexander Halim Santoso Bryan A. Wijaya Bryan Anna Wijaya Diana Dinali Ernawati Ernawati Farhan Pratomo Fransisca IR. Dewi Hendsun Hendsun Kresna Bambang Monika Monika Robert Kosasih Yohanes Firmansyah