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All Journal Journal of Biomedical and Techno Nanomaterials International Journal of Educational Narratives
Kumudu Wijerathna
University of Sri Jayewardenepura
Biochemistry, Genetics & Molecular Biology

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LIPID NANOPARTICLE-MEDIATED MRNA DELIVERY FOR A NOVEL UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS SUBTYPES Lakshan Pradeep; Kumudu Wijerathna; Dilshan Perera
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 5 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i5.2974

Abstract

Influenza viruses continue to pose a major global health challenge due to rapid antigenic drift and shift, which limit the effectiveness of seasonal, strain-specific vaccines. Current vaccine strategies require frequent reformulation and often fail to provide broad and durable protection against diverse influenza virus subtypes. This study aims to develop a lipid nanoparticle–mediated mRNA delivery platform encoding conserved influenza antigens as a novel universal vaccine strategy. An experimental preclinical design was employed, involving in vitro transcription of mRNA, formulation into lipid nanoparticles, physicochemical characterization, and immunological evaluation in animal models. Particle size, encapsulation efficiency, mRNA expression, and stability were systematically assessed, followed by analysis of humoral and cellular immune responses and heterologous viral challenge studies. The mRNA–LNP vaccine exhibited uniform nanoscale properties, high mRNA integrity, and efficient antigen expression. Immunization induced robust cross-reactive antibody responses and strong CD4? and CD8? T-cell activation against multiple influenza subtypes. Vaccinated subjects demonstrated reduced viral loads, attenuated disease severity, and improved survival following heterologous influenza challenge. These findings indicate that lipid nanoparticle–mediated mRNA delivery of conserved influenza antigens represents a promising and adaptable platform for universal influenza vaccination, with significant potential to enhance pandemic preparedness and long-term influenza control.  
Narratives of Resilience: Exploring Student Stories During Remote Learning in the COVID-19 Pandemic Catherine Li; Rahmat Hidayat; Kumudu Wijerathna; Alma Yulianti
International Journal of Educational Narratives Vol. 3 No. 6 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/ijen.v3i6.2555

Abstract

Background. The COVID-19 pandemic forced an abrupt transition from face-to-face instruction to remote learning, exposing students worldwide to significant academic, technological, and psychosocial challenges. Purpose. This study aimed to explore students’ lived experiences of resilience during remote learning by examining their narratives of adaptation, coping strategies, and personal development in online educational contexts. Method. A qualitative research design employing narrative inquiry was used. Data were collected from 50 secondary and tertiary students across diverse educational settings through in-depth narrative accounts. Results. The findings revealed that students demonstrated resilience through proactive time management, creative engagement with digital platforms, peer collaboration, and positive cognitive reframing of challenges. Participants reported enhanced self-directed learning skills, increased autonomy, and improved emotional regulation as outcomes of prolonged remote learning. Conclusion. The study concludes that resilience plays a vital role in sustaining student engagement and well-being in remote learning environments.
Co-Authors Alma Yulianti Catherine Li Dilshan Perera Lakshan Pradeep Rahmat Hidayat