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All Journal Spizaetus: Jurnal Biologi dan Pendidikan Biologi Proceeding Biology Education Conference
Neila Putri Shofiyana
Universitas Islam Negeri Sayyid Ali Rahmatullah Tulungagung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Inverse Docking dan Identifikasi Protein Target Metabolik Sekunder Senna siamea terhadap Propionibacterium acnes Neila Putri Shofiyana; Achmad Nurul Yaqin
Proceeding Biology Education Conference: Biology, Science, Enviromental, and Learning Vol 20, No 1 (2023): Proceeding Biology Education Conference
Publisher : Universitas Sebelas Maret

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Abstract

Tanaman johar (Senna siamea) diketahui memiliki aktivitas antibakteri dan telah banyak dimanfaatkan sebagai obat tradisional khususnya daunnya. Aktivitas antibakteri ekstrak daun johar telah banyak dilaporkan mampu menghambat pertumbuhan baik bakteri Gram positif dan Gram negatif. Dibandingkan bakteri lain, Konsentrasi Hambat Minimum (MIC) ekstrak daun johar terhadap Propionibacterium acnes dilaporkan jauh lebih rendah. Namun, mekanisme antibakteri dan protein reseptor targetnya belum diketahui. Penelitian ini bertujuan untuk menentukan protein target utama dan senyawa aktif dalam S. siamea untuk memahami mekanisme antibakterinya. Metode yang digunakan adalah molekuler docking senyawa yang dilaporkan pada ekstrak S. siamea pada beberapa protein bakteri P. acnes menggunakan Swissdock. Hasil dengan konformasi paling stabil dianalisis lebih lanjut dengan metode Density Functional Theory (DFT) menggunakan Gaussian 09 pada level teori HF/3-21G dan semiempirik PM6 dilanjutkan dengan analisis Interaksi Non-Kovalen (NCI) menggunakan Multiwfn. Kesimpulan dari penelitian ini adalah lipase pembentuk biofilm adalah protein target dari senyawa polar dalam daun S. siamea terutama siamosida A.
Penguatan Karakter Hidup Sehat melalui Permainan Konvensional sebagai Fondasi Menyongsong Generasi Emas 2045 Nanang Purwanto; M Iqbal Maulana; Neila Putri Shofiyana; Imel Wijayanti; Nadila Erdina Putry
Spizaetus: Jurnal Biologi dan Pendidikan Biologi Vol 6 No 3 (2025): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP, Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v6i3.634

Abstract

Conventional games are a national cultural heritage, now gradually fading and rarely found in society. This is due to the development of science and technology. This phenomenon was found among students at SDN 2 Jajar, Trenggalek Regency. Online games involve the sense of sight which is at risk of bad for children's motor and social development, while conventional games involve body parts to move, so that the body is healthier, stronger, and fitter. The population in the study included all children aged 6 to 12 years in Jajar Village. The sample included 31 students from grades one to six and 31 parents of SDN 2 Jajar students. Data collection techniques were through observation, interviews, and documentation. Data analysis techniques were descriptive qualitative. This paper explains efforts to arouse the enthusiasm and love of students at SDN 2 Jajar and Madrasah Ibtidaiyah Jajar for conventional games that are the foundation of a healthy lifestyle. The socialization was held on January 3-4, 2024, while practical activities were held on January 7 and 21, 2024. Conventional games that were socialized included Rangku Alu, Egrang, Bakiak, Gobak Sodor. The results of the socialization showed a positive response from students and parents/guardians of SDN 2 Jajar. The aim of this activity is to realize healthy children's characters to welcome the golden generation of 2045.
Co-Authors Achmad Nurul Yaqin Imel Wijayanti M Iqbal Maulana Nadila Erdina Putry Nanang Purwanto