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All Journal Jurnal Ilmu Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Anton Sumarpo
Department of Clinical Pathology, Faculty of Medicine, Maranatha Christian University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Heparin Vs Enoxaparin: Effects On D-Dimer And Hospital Stay In Covid-19 Patients Fonny Cokro; Novita Suryamin; Dion Notario; Agnes Anania Triavika Sahamastuti; Catherine Keiko Gunawan; Anton Sumarpo
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 3 (2026): Volume 13 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i3.23094

Abstract

Elevated d-dimer levels due to venous thromboembolism and hypercoagulability in covid-19 patients play a role in disease severity and poor clinical outcomes. This study aims to compare the effectiveness of heparin and enoxaparin, two recommended anticoagulants, in reducing d-dimer levels and hospital stay duration in hospitalized covid-19 patients. This retrospective cohort study involved 106 hospitalized covid-19 patients with abnormal d-dimer levels treated between March 2020 and March 2023. The assessment included changes in d-dimer levels and hospitalization duration. Statistical analyses were performed using stata software. Patients receiving enoxaparin were 5.913 times more likely to experience a reduction in d-dimer levels compared to those receiving heparin (p=0.021). While smoking status (or=0.034; p=0.001) and the number of comorbidities (or=11.247; p=0.018) were notable factors influencing d-dimer reduction, enoxaparin administration was linked to significantly longer hospitalization (p=0.024). The severity of covid-19 also had a substantial impact on hospital stays, with severe (β = 5.757; p= 0.004) and critical (β = 9.147; p 0.001) cases requiring extended care. Thus, enoxaparin demonstrates greater efficacy in reducing d-dimer levels in hospitalized covid-19 patients, though at the cost of prolonged hospital stays. 
Diagnostic Performance of Fecal pks+ Escherichia coli for Detecting Neoplastic Colorectal Lesions in Suspected Colorectal Cancer Patients Anton Sumarpo; Ida Parwati; Fajar Wasilah; Didik Setyo Heriyanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 3 (2026)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i3.2894

Abstract

Genotoxin-producing pks+ Escherichia coli is implicated in the pathogenesis of colorectal cancer (CRC). This study was designed to evaluate the diagnostic performance of fecal pks+ E. coli as a non-invasive biomarker for CRC screening. In this cross-sectional study, fecal samples from 70 patients with suspected CRC were analyzed by quantitative polymerase chain reaction (qPCR) to detect the presence of pks+ E. coli. The diagnostic accuracy was assessed against colonoscopy and histopathology findings. Against histopathology as the gold standard, fecal pks+ E. coli detected neoplastic lesions with a sensitivity of 70.59% and a specificity of 65.22%. Notably, the relative gene copy number of pks+ E. coli was significantly higher in patients with neoplastic lesions compared to those with non-neoplastic findings. Fecal testing for pks+ E. coli demonstrates potential as a non-invasive biomarker for detecting neoplastic colorectal lesions, though further validations are needed.
Co-Authors Agnes Anania Triavika Sahamastuti Catherine Keiko Gunawan Cokro, Fonny Didik Setyo Heriyanto Dion Notario Fajar Wasilah Ida Parwati Novita Suryamin