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All Journal Magna Neurologica
Esti Nur Ekasari
Department of Neurology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia

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Virtual Conventional Therapy for Motor Rehabilitation in Stroke Patients: A Systematic Review Rudi Ilhamsyah; Yetty Hambarsari; Markus Santoso; Hendry Gunawan; Esti Nur Ekasari; Krisandi Hartanto; Han Yang
Magna Neurologica Vol. 3 No. 2 (2025): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v3i2.1680

Abstract

Background: Stroke is a leading cause of disability worldwide, significantly impacting motor function, sensory, visual, and cognitive abilities. Conventional physical therapy has traditionally been used for stroke rehabilitation. However, technological advances have introduced virtual reality (VR) as a rehabilitation tool. Research has highlighted the therapeutic value of VR in improving motor functions, with some studies suggesting superior outcomes compared to traditional therapy. Despite this, the literature presents varied results, necessitating a systematic review to evaluate the breadth of evidence. Objective: This study aims to compare the effectiveness of VR therapy with conventional physical therapy in extremity function among stroke patients. Methods: A primary search was conducted across PubMed, Scopus, and ProQuest databases using keywords related to stroke, VR, and conventional therapy. Studies will be included if they compare the efficacy of VR with conventional therapy in stroke rehabilitation. Non-comparative studies, non-English publications, and irrelevant topics will be excluded. Results: A literature search yielded 15 eligible journals using a randomized clinical trial. Analysis showed that 4 out of 15 articles found VR therapy not superior to conventional therapy, while the other 11 articles demonstrated that VR therapy statistically improved patient conditions compared to conventional therapy. Conclusion: VR-based exercises stimulate cortical reorganization and strengthen neural systems involved in motor planning, learning, and execution. Most studies indicate that VR therapy is more effective in enhancing motor recovery, balance, and limb function in stroke patients and increasing patient motivation and engagement than conventional training.
Vitamin D Receptor Gene Polymorphisms in Multiple Sclerosis Susceptibility: Updated Systematic Review and Meta-Analysis Han Yang; Baarid Luqman Hamidi; Esti Nur Ekasari; Krisandi Hartanto; Rudi Ilhamsyah
Magna Neurologica Vol. 4 No. 1 (2026): January
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v4i1.2417

Abstract

Background: The relationship between Vitamin D Receptor (VDR) gene polymorphisms and the risk of developing Multiple Sclerosis (MS) has been explored in numerous studies. However, the results were inconclusive. Therefore, this study aimed to investigate the relationship between VDR gene polymorphisms and susceptibility to MS. Objective: This study aimed to systematically evaluate the association between Vitamin D Receptor (VDR) gene polymorphisms and susceptibility to Multiple Sclerosis (MS) through a meta-analysis of existing studies. Methods: This study is a meta-analysis conducted in accordance with the PRISMA guideline. The literature search was conducted using the PubMed and Google Scholar databases from January 2014 to December 2024. Studies included in this meta-analysis were assessed using the Newcastle-Ottawa Scale (NOS). The association between VDR polymorphisms and the risk of MS was evaluated using pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: Six studies (868 cases/982 controls) were included. The TaqI polymorphism showed that TT vs TC + CC was associated with reduced risk of MS (OR 95% CI = 0.43 [0.21 - 0.86], p = 0.02), while CC vs TT + TC was associated with an increased risk of MS (OR 95% CI = 1.89 [1.51 - 2.36], p < 0.00001). T vs C was associated with reduced risk of MS (OR 95% CI = 0.69 [0.49 - 0.98], p = 0.04) while C vs T was associated with an increased risk of MS (OR 95% CI = 1.45 [1.02 – 2.05], p < 0.04). Conclusion: In summary, our meta-analysis revealed a significant association between VDR gene polymorphism and MS susceptibility in certain genetic models of the VDR gene.