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All Journal Pharmaciana: Jurnal Kefarmasian Unram Journal of Community Service (UJCS)
A’yunil Hisbiyah
Universitas Anwar Medika
Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences

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Metabolite profiling and computational analysis of alkaloids of Carica papaya L. var. California leaves ethanol extract as a drug candidate Martina Kurnia Rohmah; A’yunil Hisbiyah; Tutiek Purwanti
Pharmaciana Vol. 16 No. 2 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i2.31597

Abstract

Papaya (Carica papaya L.) var. California leaves are widely used as traditional medicine. Several scientific studies have demonstrated that papaya leaves possess biological and pharmacological properties, with potential to be developed into a therapeutic agent. Papaya contains major secondary metabolites from the alkaloid group, including carpaine, pseudocarpaine, emetine, and dehydrocarpaine. As a major compound, we need to know its physicochemical properties, target and receptor binding properties, and potential biological functions. This research aims to determine ADME characteristics, predict target proteins, and assess drug similarity. We identified an alkaloid compound in the ethanol extract of Carica papaya L. var. California is using LC-HRMS. We utilized the Swiss ADME Webserver to analyze ADME properties, predict protein targets, and perform drug similarity analysis. We used various references to study the biological activity and effect of alkaloids on various receptor binding. LC-HRMS showed that the Carica papaya L. var. California leaves contain ethanol extracts that contain some alkaloids, including carpaine (58.3%), pseudocarpaine (2.49%), emetine (0.12%), dehydrocarpaine II (0.07%), and dehydrocarpaine I. ADME analysis showed good oral absorption, widespread distribution, no CYP-mediated interactions, and low clearance. Target prediction studies showed that papaya leaf alkaloids have three main targets: protein kinases, G protein-coupled receptors (GPCRs), and proteases. Drug similarity studies showed that papaya leaf alkaloids share structural similarities with several drugs that play roles, including anti-inflammatories, antivirals, immunosuppressants, anticancer agents, vasodilators, modulators of the nervous and cardiovascular systems, and muscle relaxants.
Training on the Production of Chitosan Fish Preservatives (PETASAN) and Digital Marketing for Fish Traders in Kalanganyar Village A’yunil Hisbiyah; Eviomitta Rizki Amanda; Suryo Hadi Kusumo; Martina Kurnia Rohmah
Unram Journal of Community Service Vol. 6 No. 4 (2025): December
Publisher : Pascasarjana Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/ujcs.v6i4.1303

Abstract

Kalanganyar Village is a village located at the eastern tip of Sidoarjo Regency. Geographically, Kalanganyar Village borders directly on the sea, so almost 2/3 of the area of ​​Kalanganyar Village is aquaculture area. Most of the residents' livelihoods are subsistence farming and fish trading. The problems faced by village residents are related to food security and marketing management. Therefore, there is a need for training on fish preservatives made from natural ingredients, namely chitosan, and digital-based marketing for fish traders. The method for implementing this activity is the Participatory Rural Appraisal method; a group of fish traders are involved in planning and carrying out this community service activity. This activity improved the quality of fish products by using chitosan-based preservatives, increasing product hygiene, and increasing skills in conducting digital marketing using the help of artificial intelligence. From this activity, a plucking thorn group and a mundak bati group were also produced, which had a governance organizational structure so that the operational management of the group was more structured and neat, both of which were approved by a decree from the Head of Kalanganyar Village.
Co-Authors Eviomitta Rizki Amanda Martina Kurnia Rohmah Suryo Hadi Kusumo Tutiek Purwanti