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All Journal Pharmaciana: Jurnal Kefarmasian Journal Pharmaceutical Science and Application (JPSA)
Made Krisna Adi Jaya
Department of Pharmacy, Faculty of Math and Science, Universitas Udayana, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Reliability and risk classification agreement of digital HYPOGLYRISK: implications for standardized medication safety services Made Krisna Adi Jaya; Zullies Ikawati; Fita Rahmawati; Nanang Munif Yasin
Pharmaciana Vol. 16 No. 2 (2026): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v16i2.32020

Abstract

Hypoglycemia caused by medications is still a major safety issue for people with type 2 diabetes who are in an ambulatory therapy. To support pharmacists lead interventions, structured risk stratification is needed. The Medication-Related Hypoglycemia Risk Score Assessment Tool (HYPOGLYRISK) has been subjected to psychometric validation and digital development. However, its reproducibility among practitioners is crucial prior to broader implementation. This study assessed the inter-rater reliability and risk classification concordance of the digital HYPOGLYRISK instrument among practicing pharmacists. A methodological reliability and agreement study was performed with 46 licensed pharmacists who independently evaluated three standardized simulated patient cases categorized as low, moderate, and high risk using a digital platform. We used the intraclass correlation coefficient to look at the inter-rater reliability of total scores and the descriptive method to look at categorical agreement. The reliability test showed almost perfect agreement, with an intraclass correlation coefficient of 0.995 (95% confidence interval: 0.988-0.999). There was no difference in how the raters classified the risk categories for any case. There was perfect agreement for the clinical risk factor part, but there was a small difference in numbers for the behavioral medication safety part in the moderate-risk case, which involved 8.7% of raters. This did not change the final risk categorization. There was no misclassification between extreme risk categories. These results show that the digital HYPOGLYRISK tool gives very consistent scores and stable risk stratification across pharmacists. This finding supports its use as a standardized tool for pharmacist-led medication safety services in ambulatory diabetes care.
IDENTIFICATION OF THERAPY PROFILE AND FACTORS RELATED TO INCIDENCE OF PULMONARY TUBERCULOSIS IN DENPASAR BALI Annisa Hanum; Made Krisna Adi Jaya; I Made Bakta
Journal Pharmaceutical Science and Application Vol. 2 No. 1 (2020): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i01.p01

Abstract

Background: Tuberculosis is a problem for millions of people around the world. Indonesia as the second biggest country with the highest number of Pulmonary Tuberculosis that treatment has improved gradually. Denpasar is a city with the highest sufferers in Bali. It’s caused by the high rate of population, dense human settlement, and other related factors. Objective: Profiling incident and pulmonary tuberculosis treatment in Denpasar City primary health care. Methods: Observational study with cross-sectional analytic approaches. Forty pulmonary tuberculosis patients and One hundred twenty non-tuberculosis patients were observed in this study. Those were taken by multistage random sampling. Data were collected from medical records and questionnaires. A Chi-Square test was used for analyzing data. Results: Pulmonary tuberculosis sufferers are in productive ages which 65% were men. The treatment profile was excellently seen from the final treatment results of 31 people recovered and 9 people with complete treatment. Factors that have a statistical relation with pulmonary tuberculosis were occupation (p=0,012), income (p=0.003), smoking behavior (p=0.001), and contact history (p=0.001). The other factors with no relationship were education (p=0.270) and occupancy density (p=0.540). Conclusion: Pay attention to the caused factors of tuberculosis infection; society is suggested to implement a healthy lifestyle, maintain home sanitation, and environment. Keywords: Factor Related; Pulmonary; Tuberculosis; Primary Health Care; Denpasar City
SIDE EFFECTS PROFILE OF ANTIPLATELET MEDICATION IN PATIENTS WITH CORONARY HEART DISEASE AT BHAYANGKARA HOSPITAL BALI-INDONESIA Anak Agung Indah Astrijayanti; Ida Ayu Manik Partha Sutema; Ni Putu Wulanda Evayanti; Ni Ketut Tria Purnamisari; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 2 No. 2 (2020): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p02

Abstract

Introduction: Coronary heart disease (CHD) is a disorder of heart function due to a lack of blood in the heart muscle due to narrowing of the coronary arteries. Antiplatelet in patients with CHD is a therapy that must be obtained by patients throughout their lives to prevent recurrent attacks and deaths from CHD. In the Province of Bali, especially in Denpasar, there is a lack of information about the type of side effects that occur on antiplatelet medication, so it is necessary to do a related study. Objective: The aim of this study is to identify the type of side effects that occur on antiplatelet medication in patients with CHD. Methods: A cross-sectional study involving 97 patients was done by observed the CHD patients treated with antiplatelet medication. Side effects were evaluate using Naranjo Algorithm. Patients were divided into three groups, including a low dose aspirin user group, clopidogrel user group, and aspirinclopidogrel combination user group. Results: Antiplatelet side effects that occur in patients include headache (2.06%), diarrhea (1.03%), cyanosis (1.03%), gastrointestinal bleeding (8.25%), heartburn (11.34%), and nausea (6.19%). These side effects only occurred in 31.96% of the total subjects. The incidence of aspirin side effects was significantly greater than clopidogrel as well as aspirin-clopidogrel in combination (p <0.05). Conclusion: Patients with CHD who use antiplatelet agents in the long term to be more aware of the potential side effects that will occur, especially heartburn in chronic low-dose aspirin users. Keywords: Coronary Heart Disease; Side Effects; Antiplatelet; Aspirin; Clopidogrel
IDENTIFICATION OF PUBLIC MEDICINE STORAGE PROFILE IN THE COMMUNITY PHARMACY: A SYSTEMATIC REVIEW Kadek Valentina Renita Dewi; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p03

Abstract

Background: Drug is the most common form of therapy and an integral part of almost all levels of care. The conditions and proper way of storing medicines at home are important aspects of safe and effective drug treatment. Information about the knowledge of patients with appropriate storage conditions, rational drug use, appropriate drug use and management of various drugs is essential in helping pharmacists identify which medicinal products and aspects of home storage require more attention when counseling patients. Objective: The aim of this systematic review is to identify and characterize the mode of storage associated with home-stored pharmaceuticals. Methods: This systematic review analyzes the storage methods for medicines to identify and characterize the storage methods associated with medicines stored at home. The limitation of publication used, namely English and Indonesian in the last 10 years, and obtained through literature that can be considered relevant. Result: This systematic review was conducted in the period July, August, September 2020 - February 2021. As many as 20 journals were obtained. Those who met the inclusion criteria were 10 journals. Of the 10 journals that had met the inclusion criteria, 3 journals were excluded so that only 7 journals were used in literature review / systematic review.Storage of medicines in the household is based on the presence of family members who have certain diseases so that they have to consume drugs in the long term, the presence of health workers, and the education level of family members. Problems that can arise with drug storage conditions are impaired drug stability and can accelerate drug degradation prematurely. Storage of medicines in the medicine cabinet and out of reach of children is highly recommended. Placement of drugs in one place without being separated and a lack of awareness in administering specific markings can increase drug administration errors and lead to noncompliance with over-the-counter drug use. The application of drug management in the family can improve the quality of life and avoid the adverse effects of drug misuse. Conclusion: This study raises relation to medicines stored inside homes that warrant addressing that need pharmacists regarding public education in relation to drug therapy that goes beyond the dispensing process. Judging by the fnding that pharmacists were not considered primary sources of drug-related information. The good practices should be encouraged through continued health education at health institutions and medicine retail outlets. Keywords: Drugs; Storage; Household
ANALYSIS OF POTENTIAL INTERACTIONS OF RAMIPRIL - AMBON BANANA (Musa paradisiaca var. sapientum (L.) Kunt.) ON HYPERKALEMIA RISK IN WHITE RATS I Gusti Ayu Sintia Dewi; Ni Putu Rutin Seciolini Agristy; Ida Ayu Gendari; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p05

Abstract

Introduction: Drug and food interaction is a condition in which nutritional factors present in food have a significant influence effect on drug therapy, both potentially increasing or decreasing the effect of drug therapy. Indonesian people have a habit of taking medicine by using food or drink. Bananas are the primadonna that is often consumed to speed up the swallowing process and reduce the bitter taste of medicine. It turns out that the consumption of bananas together with ACE inhibitors can increase the risk of hyperkalemia. Lack of information about the effects caused by drug and food interactions, so it is necessary to do related research. Objective: This study aims to determine the interaction of giving ramipril together with Ambon banana on the risk of hyperkalemia. Methods: A real experimental study while still adhering to the Covid'19 health protocol. White rats were divided into four groups, conditioned by hypertension, then intervened with ramipril and Ambon banana. Blood serum was taken and analyzed using UV spectrophotometry to obtain serum potassium levels. The levels obtained were analyzed using the One Way ANOVA Test. Results: The mean serum potassium level of the positive control group was 4.93±0.58; negative control 4.13±0.60; normal control 4.76±0.59 and treatment 5.10±0.38. The highest serum potassium level was in the ramipril treatment group together with Ambon banana, but still in the normal range of 3.60– 5.50 mmol/L. One Way Anova test results (p = 0.054). (p>0.05) showed no significant difference. Conclusion: There is no specific increase in levels of ramipril concurrently with Ambon banana so it does not have the potential to cause the risk of hyperkalemia. Keywords: Drug Interaction; Ramipril; Ambon Banana; Serum Potassium; Hyperkalemia
FIGURE OF POTENTIAL MEDICATION ERROR IN MEDICINE PRESCRIPTION FOR OUTPATIENT SERVICES OF "X" HOSPITAL IN BALI Dewa Gede Wahyu Nuryatama; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p02

Abstract

Background: Medication errors (ME) in health services; in this case, hospitals are supposed to have zero accidents. Evaluation of the potential ME, such as doctor's prescription writing, must still be carried out in an effort to maintain service quality, especially in maintaining patient safety or preventing medication errors. Objective: This research aimed to see the figure of potential medication errors that occur in the prescribing process, in this case, is related to the completeness of the prescription seen from the administration and pharmaceutical approach, as well as the legibility of the prescriptions originating from outpatient services at one of the hospitals in Bali. Methods: This research was observational with a qualitative descriptive approach. Data collection was carried out retrospectively through medication prescriptions for patients received by pharmaceutical installations for outpatient services at hospitals from July until October 2022, totaling 110 prescriptions. Results: Results showed that 1.8% of prescriptions still did not write down the patient's name, then 9.1% of prescriptions had not written down the patient's age, 21.8% of prescriptions had not written down the patient's gender, and as many as 93.6% of prescriptions did not include the patient's weight, 2.7 % of prescriptions did not include the name of the doctor, 75.5% of the prescriptions did not include the doctor's SIP number, 1.8% of the prescriptions still did not write down the rules for using the drug, 10.9% of the prescriptions did not write down the strength of the drug dosage and 19.1% of the prescriptions did not provide information about dosage form to be administered to the patient. This study also shows 8.9% of the prescriptions are Illegible prescription. Conclusion: The results of the research found that administratively and pharmaceutically incomplete prescriptions and also Illegible prescription writing were still found. So the results of this study show how important it is to always evaluate the potential of medication errors, especially at the prescribing and transcribing phases, to improve patient safety. Keywords: Medication error; Prescription; Hospital; Retrospective
Co-Authors Anak Agung Indah Astrijayanti Annisa Hanum Dewa Gede Wahyu Nuryatama Fita Rahmawati I Gusti Ayu Sintia Dewi I Made Bakta Ida Ayu Gendari Kadek Valentina Renita Dewi Nanang Munif Yasin Ni Ketut Tria Purnamisari Ni Putu Rutin Seciolini Agristy Ni Putu Wulanda Evayanti Sutema, Ida Ayu Manik Partha Zullies Ikawati