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All Journal JOURNAL LA MEDIHEALTICO
Hasan Hasan
Department of Internal Medicine, Faculty of Medicine, Universitas Muslim Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Vitamin E Supplementation and Its Impact on Pulmonary Tuberculosis Treatment Outcomes: A Systematic Review Adhelia Zalsabilah Basir; Edward Pandu Wiriansya; Suciati Damopolii; Hasan Hasan; Indah Lestari Daeng Kanang
Journal La Medihealtico Vol. 6 No. 6 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i6.2776

Abstract

Pulmonary tuberculosis remains a global health problem, and antioxidant deficiencies such as vitamin E contribute to increased oxidative stress in patients. The aim of this study was to assess the effect of vitamin E supplementation on the effectiveness of pulmonary tuberculosis treatment through a systematic review based on PRISMA 2020 guidelines. This systematic review included clinical and observational studies investigating the relationship between vitamin E and pulmonary tuberculosis. Literature searches were conducted in PubMed and Google Scholar (2008–2021) using the keywords “Vitamin E,” “Tuberculosis,” and “Lung.” Methodological quality was assessed using the JBI Checklist and Cochrane RoB2. The process was carried out at the Faculty of Medicine, Muslim University of Indonesia, Makassar, from March to August 2024. Secondary data from published studies were used; therefore, ethical approval was not required. Six studies met the inclusion criteria, consisting of two randomized controlled trials, two in vitro studies, one case–control study, and one cross-sectional study. The synthesis results showed that vitamin E supplementation consistently reduced oxidative stress, as indicated by a significant decrease in malondialdehyde (MDA) levels and an increase in enzyme activity. In addition, vitamin E improved inflammatory status through reduced C-reactive protein (CRP) levels and increased serum leptin, as well as enhanced cellular immune responses through elevated IL-2 and IFN-γ levels. Overall, vitamin E supplementation contributed to improved treatment effectiveness and quality of life in patients with pulmonary tuberculosis.Vitamin E supplementation has potential as an adjuvant therapy that enhances the effectiveness of pulmonary tuberculosis treatment through antioxidant and immunomodulatory mechanisms.
Literature Review: A Comparative Analysis of Postoperative Urinary Tract Infection Risk between Long-Term and Short-Term Catheterization Nurfaisah Fadilah; Aziz Beru Gani; Hasan Hasan
Journal La Medihealtico Vol. 7 No. 1 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i1.3073

Abstract

The insertion of a urinary catheter is a routine procedure in various surgical interventions to keep the bladder empty; however, prolonged catheterization is known to increase the risk of urinary tract infection (UTI) through biofilm formation, bacterial colonization, and enhanced antimicrobial resistance. This study aims to compare postoperative UTI risk between short-term and long-term catheterization to determine the safest optimal duration. The research method uses a narrative literature review of nationally and internationally indexed journals published between 2015 and 2025, using keywords related to CAUTI, short-term catheterization, long-term catheterization, and catheter duration. Analysis of 25 cohort studies showed that long-term catheter use (>7 days) results in a significantly higher incidence of CAUTI (26.7% vs 7.1%) with a relative risk of 3.84, with infection onset rising sharply from day 3 and reaching a plateau after day 14, as well as a predominance of multidrug-resistant pathogens such as Pseudomonas aeruginosa and Enterococcus faecalis. The pathogenesis involves mature biofilm formation by days 7–10, increased expression of resistance genes, and enhanced horizontal gene transfer. These findings confirm that catheter duration is the strongest independent risk factor for CAUTI, and strategies such as early catheter removal, nurse-driven removal protocols, antimicrobial-coated catheters, and closed drainage systems have been shown to reduce CAUTI incidence by 40–60%. In conclusion, short-term catheterization is significantly safer than long-term use, and implementing protocols to reduce catheter duration is the most effective measure in preventing postoperative CAUTI.
Co-Authors Adhelia Zalsabilah Basir Aziz Beru Gani Edward Pandu Wiriansya Indah Lestari Daeng Kanang Nurfaisah Fadilah Suciati Damopolii